Novel decapping enzyme for cofactor- and “canonically”-capped RNA species
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Ref.-Nr.: 0706-6709-IKF
Technology
Scientists from the Max-Planck-Institute for Terrestrial Microbiology have identified the bacteriophage T4-encoded Nudix hydrolase NudE.1 — named based on its sequence homology to E. coli Nudix hydrolase NudE. NudE.1 was found to be more efficient than NudC in
- Decapping of NAD-capped RNA (9 times more efficient than NudC)
- Hydrolysis of NAD and AMP (2 times more efficient than NudC)
- Decapping of m7G-capped RNA
- Hydrolysis of diphosphate dinucleotides and metabolic co-factors containing an ADP moiety such as Ap(n)A, FAD,
Coenzyme A - Removal of posttranslational protein modifications (PTMs) such as ADP-ribosylation and RNAylation

Patent Information
A priority establishing patent application was filed on February, 12th 2024.
Publications
Wolfram-Schauerte et al., https://www.biorxiv.org/content/10.1101/2024.04.04.588121v1
Pozhydaieva et al., Current Opinion in Microbiology 2024. https://doi.org/10.1016/j.mib.2023.102417
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- Ref.-Nr.: 0706-6709-IKF (574,7 KiB)
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