Carbon-neutral and carbon-positive photorespiration bypass routes supporting higher photosynthetic rate and yield
The research group of Arren Bar-Even from the Max-Planck-Institute of Molecular Plant Physiology designed synthetic photorespiration bypass routes that directly tackle the deficits and inefficiencies of photorespiration. These synthetic pathways lead from 2-PG to an intermediate of the rPP cycle, while avoiding CO2 and NH3 release. These synthetic routes were analyzed and compared according to multiple physicochemical parameters, including thermodynamic feasibility, kinetic favorability, and minimal overlap with central metabolism. Pathways with promising properties were further analyzed manually at high resolution with special emphasis on those that can be implemented in many parallel ways to ensure that multiple backups are available to overcome any potential bottleneck component. The most promising routes are expected to support 60% higher biomass yield per turn of the rPP cycle and >30% higher yield per ATP.
Currently, as part of the FutureAgriculture project, funded by the EU (Project number 686330), a consortium headed by Arren Bar-Even is aiming to implement the synthetic pathway in vitro and in vivo in cyanobacteria and plants.
Max-Planck-Innovation, the tech-transfer agency of Max Planck Society is currently looking for licensees or developmental cooperations.
EP priority application was filed June 2015. PCT patent application was filed in June 2016.
- Ref.-Nr.: 0402-5003-MG (223,2 KiB)
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