Nukleinsäure-, Protein-, Zell-bezogene Technologien

Erweiterte Suche

 

Treffer

Ref.-Nr.: 0105-5855_1-IKF

Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...

Ref.-Nr.: 0105-5855_2-IKF

Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...

Ref.-Nr.: 0106-5185-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions

Ref.-Nr.: 0602-5504-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis

Ref.-Nr.: 0603-4987-IKF

Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.

Ref.-Nr.: 1013-4990-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.

Ref.-Nr.: 0803-5308-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

An innovative chemical inducer of dimerization for studying protein interactions in cells, that overcomes challenges of available dimerizers.

Ref.-Nr.: 0706-5707-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Arzneimittel-Darreichung
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.

Ref.-Nr.: 0707-5990-MG

Analytik
IT / Software / Bioinformatik : (andere) Software
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

MARS is a powerful program for robust automatic backbone assignment of proteins. MARS is applicable to proteins with extreme chemical shift degeneracy such as high molecular weight proteins and partially disordered or fully intrinsically disordered proteins. MARS is successfully used in many labs world-wide as evidenced by a huge number of citations.

Ref.-Nr.: 1013-5012-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

A method for de novo generation and long-term culture of epidermis-derived stems cells in feeder-free conditions and a special cell culture medium for in vitro tissue production, drug discovery and toxicity screenings, and medical applications.

Ref.-Nr.: 1012-4727-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

A method to reprogram bone endothelial cells into cells that are able to mediate bone angiogenesis and osteogenesis, opening new avenues to treat osteoporosis.

Ref.-Nr.: 0803-5480-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.

Ref.-Nr.: 0707-5639-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression

Ref.-Nr.: 1013-5354-IKF

Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...

Ref.-Nr.: 0402-5469-MG

Analytik
IT / Software / Bioinformatik : Bioinformatik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.

Ref.-Nr.: 0402-5439-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

Ref.-Nr.: 0214-5029-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Unique multifunctional oligonucleotide for the ultrafast transcriptome-wide identification of RNA-binding protein (RBP) targets.