Nukleinsäure-, Protein-, Zell-bezogene Technologien
A novel inhibitor targeting matrix accumulation in cancer
Ref.-Nr.: 0105-5855_1-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...
Weiterlesen … A novel inhibitor targeting matrix accumulation in cancer
A novel inhibitor targeting matrix accumulation in fibrosis
Ref.-Nr.: 0105-5855_2-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...
Weiterlesen … A novel inhibitor targeting matrix accumulation in fibrosis
A novel strategy for reducing inflammation by modulating immune cell metabolism
Ref.-Nr.: 0106-5185-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions
Weiterlesen … A novel strategy for reducing inflammation by modulating immune cell metabolism
Do you need to shut down protein synthesis reversibly and in a cell-type specific manner?
Ref.-Nr.: 0602-5504-LI
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)
A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis
FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Ref.-Nr.: 0603-4987-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.
Weiterlesen … FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
Ref.-Nr.: 1013-4990-IKF
Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.
Weiterlesen … Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
LITESEC - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
Ref.-Nr.: 0706-5707-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Arzneimittel-Darreichung
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.
MARS – software for robust and automatic backbone assignment of protein NMR spectra
Ref.-Nr.: 0707-5990-MG
Analytik
IT / Software / Bioinformatik : (andere) Software
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
MARS is a powerful program for robust automatic backbone assignment of proteins. MARS is applicable to proteins with extreme chemical shift degeneracy such as high molecular weight proteins and partially disordered or fully intrinsically disordered proteins. MARS is successfully used in many labs world-wide as evidenced by a huge number of citations.
Weiterlesen … MARS – software for robust and automatic backbone assignment of protein NMR spectra
New cell type promoting osteogenesis in bone
Ref.-Nr.: 1012-4727-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
A method to reprogram bone endothelial cells into cells that are able to mediate bone angiogenesis and osteogenesis, opening new avenues to treat osteoporosis.
New KDAC assay and selection system
Ref.-Nr.: 0803-5480-IKF
Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.
Novel antiviral therapy against HIV-1 and alphaviruses: reducing frameshifting by increasing tRNALeu concentrations
Ref.-Nr.: 0707-5639-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression
Novel Biomarkers for Ageing and Metabolic Health
Ref.-Nr.: 1013-5354-IKF
Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.
Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...
Weiterlesen … Novel Biomarkers for Ageing and Metabolic Health
Predicting Concentrations, Reactions Rates and Rate Constants in Biochemical Networks
Ref.-Nr.: 0402-5469-MG
Analytik
IT / Software / Bioinformatik : Bioinformatik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.
Weiterlesen … Predicting Concentrations, Reactions Rates and Rate Constants in Biochemical Networks
SUMOvera: A Truly Orthogonal Cleavage Module
Ref.-Nr.: 0402-5439-LI
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.
Unique multifunctional oligonucleotide enabling ultrafast RNA-protein interactions in cells and other uses thereof
Ref.-Nr.: 0214-5029-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Unique multifunctional oligonucleotide for the ultrafast transcriptome-wide identification of RNA-binding protein (RBP) targets.