Medizin

Cholestatic liver diseases are a heterogeneous group of disorders resulting from genetic, metabolic and congenital defects, as well as DILI (drug-induced liver injury, a leading cause of attrition during drug development).

Current diagnostic techniques for DILI and cholestasis are based on the detection of serum markers and imaging methods such as computer tomography. However, these have a low resolution and only provide a limited understanding of the underlying disease etiology. Therapeutic ...

Diese neuartige schraubenfreie Kupplung, die auch als Überlastungskupplung eingesetzt werden kann, bietet die Möglichkeit ohne zusätzliches Werkzeug zwei drehbare Elemente auch unter extrem engen Bedingungen, spielfrei und kraftschlüssig mit hoher Präzision miteinander zu verbinden. Bisher auf dem Markt bekannte Kupplungen sind aufgrund ihrer Größe für Anwendungen im Bereich der Elektronik, der Optik, der Messtechnik sowie der Präzisionstechnik ungeeignet. Wohingegen dank der neuen Technologie, ...

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.

Antiviral therapy against retroviruses and alphaviruses using tRNA^Leu(UUA) overexpression