Medizin
A new VACCINE type able to induce STERILIZING IMMUNITY against epidemic threats caused by viruses such as SARS-CoV-2 (COVID-19) or other respiratory pathogens
Ref.-Nr.: 0204-3324-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Vakzine

"Novel first-in-class intra-nasally applicable safe recombinant "vir4vac" RNA vaccines constitute a very safe and efficacious way of preventing serious infections of respiratory corona and paramyxoviruses as well as other respiratory viruses.“
A novel biomarker for a reliable diagnosis of colorectal cancer based on differentially methylated genomic regions
Ref.-Nr.: 0301-4550-LI
Medizin : Diagnostika
With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...
A novel inhibitor targeting matrix accumulation in cancer
Ref.-Nr.: 0105-5855_1-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...
Weiterlesen … A novel inhibitor targeting matrix accumulation in cancer
A novel inhibitor targeting matrix accumulation in fibrosis
Ref.-Nr.: 0105-5855_2-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...
Weiterlesen … A novel inhibitor targeting matrix accumulation in fibrosis
Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Ref.-Nr.: 0305-3252-LI
Medizin : Therapeutika

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...
Weiterlesen … Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Coupling part
Ref.-Nr.: 0704-5610-BC
Medizin : Diagnostika
Sensoren, Geräte und Komponenten

Diese neuartige schraubenfreie Kupplung, die auch als Überlastungskupplung eingesetzt werden kann, bietet die Möglichkeit ohne zusätzliches Werkzeug zwei drehbare Elemente auch unter extrem engen Bedingungen, spielfrei und kraftschlüssig mit hoher Präzision miteinander zu verbinden. Bisher auf dem Markt bekannte Kupplungen sind aufgrund ihrer Größe für Anwendungen im Bereich der Elektronik, der Optik, der Messtechnik sowie der Präzisionstechnik ungeeignet. Wohingegen dank der neuen Technologie, ...
FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Ref.-Nr.: 0603-4987-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.
Weiterlesen … FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
LITESEC - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
Ref.-Nr.: 0706-5707-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Arzneimittel-Darreichung
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.
Mouse model for mitochondrial diseases
Ref.-Nr.: 1013-4827-IKF
Medizin : Tiermodelle
Forschungs-Reagenzien
A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.
New cell type promoting osteogenesis in bone
Ref.-Nr.: 1012-4727-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
A method to reprogram bone endothelial cells into cells that are able to mediate bone angiogenesis and osteogenesis, opening new avenues to treat osteoporosis.
New KDAC assay and selection system
Ref.-Nr.: 0803-5480-IKF
Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.
Novel antiviral therapy against HIV-1 and alphaviruses: reducing frameshifting by increasing tRNALeu concentrations
Ref.-Nr.: 0707-5639-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression
Novel Biomarkers for Ageing and Metabolic Health
Ref.-Nr.: 1013-5354-IKF
Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.
Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...
Weiterlesen … Novel Biomarkers for Ageing and Metabolic Health
Novel glycan markers for diagnosis and vaccine against toxoplasmosis
Ref.-Nr.: 0401-4561-MG
Medizin : Diagnostika
Synthetic Glycosylphosphatidylinositols (GPIs) with high selectivity and purity for Toxoplasmosis diagnosis and vaccine.
Weiterlesen … Novel glycan markers for diagnosis and vaccine against toxoplasmosis