Medizin
A novel biomarker for a reliable diagnosis of colorectal cancer based on differentially methylated genomic regions
Ref.-Nr.: 0301-4550-LI
Medizin : Diagnostika
With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...
A novel inhibitor targeting matrix accumulation in cancer
Ref.-Nr.: 0105-5855_1-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...
Weiterlesen … A novel inhibitor targeting matrix accumulation in cancer
A novel inhibitor targeting matrix accumulation in fibrosis
Ref.-Nr.: 0105-5855_2-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...
Weiterlesen … A novel inhibitor targeting matrix accumulation in fibrosis
Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Ref.-Nr.: 0305-3252-LI
Medizin : Therapeutika

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...
Weiterlesen … Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Anti-breaking Superhydrophobic and Photocatalytic Active Films used as Blood Repellent Dressing
Ref.-Nr.: 0903-5907-LC
Medizin
Neue Materialien

Highly elastic, photocatalytic active, and superhydrophobic films were prepared by self-assembly of TiO2 nanoparticles driven by crosslinking reactions of PDMS. The photocatalytic activity of the film provides self-cleaning and antibacterial properties when exposed to UV-A light. Substrates of different materials such as glass, PU, and polyester textiles can be easily modified with the film. The corresponding PDMS/TiO2 film based wound dressings can effectively block leakage ...
Application of novel channelrhodopsins: molecular engineering, site-specific opsin targeting, discovery of new variants and the advancement in optogenetic devise development
Ref.-Nr.: 0601-4259-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...
Bottom-up assembly of synthetic extracellular vesicles for biomedical applications
Ref.-Nr.: 0105-5888-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Prozesse und Methoden (inkl. Screening) : Produktion
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Natural extracellular vesicles (EVs) are lipid vesicles that carry a plethora of biologically active molecules including soluble and membrane proteins, nucleic acids and metabolites. They have recently been recognized as a promising cell-free alternative to cell transplantation or as a novel therapeutic tool in various diseases. Many in vitro and in vivo studies have shown beneficial effects of EVs from different cell types in diseases ranging from cardiovascular conditions to ...
Weiterlesen … Bottom-up assembly of synthetic extracellular vesicles for biomedical applications
Combined inhibition of human plasmacytoid dendritic cell activity during systemic lupus erythematosus (SLE)
Ref.-Nr.: 0106-6082-MG
Medizin : Therapeutika

New therapeutic targets for plasmacytoid dendritic cell (pDC)-related autoimmune diseases like lupus, which in an combinatorial treatment reduce dose-specific toxicitiy effects.
Decontamination of radioactive caesium in humans
Ref.-Nr.: 0042-5371-LC / SGK A477
Prozesse und Methoden (inkl. Screening)
Medizin

Prof. Klaus-Richard Pörschke and co-workers from the MPI for Coal Research developed a highly hydrophobic perfluoroaryl borate (FAB) ligand for trapping the radioative 134/137 Cs isotopes with 100% specificity. The novel approach could improve the decontamination of humans compared to the administration of so called insouble Prussian blue currently in use.
Weiterlesen … Decontamination of radioactive caesium in humans
Dual Inhibition of plexin-B1 and plexin-B2
Ref.-Nr.: 0603-5770-IKF
Medizin : Therapeutika
A novel molecular target of the semaphorin-plexin system to develop treatment options for cancer and for osteoporosis.
Exploitation of mineral cesium from mineral sources
Ref.-Nr.: 0042-5371-LC / SGK A477
Prozesse und Methoden (inkl. Screening)
Medizin

Prof. Klaus-Richard Pörschke and co-workers at the MPI for Coal Research developed a novel cyclic process for the quantitative extraction of cesium with 100% selectivity from any given aqueous or acidic solution, irrespective of the other components.
Weiterlesen … Exploitation of mineral cesium from mineral sources
f-Chrimson and vf-Chrimson, two ultrafast variants of the red-light activated channelrhodopsin Chrimson
Ref.-Nr.: 0601-5208-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues, and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...
FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Ref.-Nr.: 0603-4987-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.
Weiterlesen … FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Genome-Editing-Technologies - Cas9 double mutant with improved specificity compared to wild-type
Ref.-Nr.: 0306-5787-LI
Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien
The RNA-programmable DNA-endonuclease Cas9 is widely used for genome engineering, where a high degree of specificity is required. Though this is a mechanism well controlled by canonical base-pairing, there is evidence that Cas9 does accept mismatches under certain circumstances.
This might be seen as a threat to precision needed in genome engineering at least in environments where such high precision is ultimately needed and acceptance of mismatches needs to be avoided, e.g.: cellular gene ...
Genome-Editing-Technologies - Single compound or compound mix dramatically improve Homology-Directed-Repair (HDR)
Ref.-Nr.: 1306-5734-LI & 1306-5288-LI
Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien
Precise genome editing demands for homology-directed repair (HDR) by aiming to introduce a new double stranded DNA substituting for a homologous sequence but partially defect one. This substrate dependent reaction does compete with direct non-homologous end joining (NHEJ) of the double strand breaks. NHEJ is error-prone and is therefor mainly used for gene inactivation.
The rate of NHEJ is directly limiting the rate of HDR. For this reason HDR in vitro does occur on a very low level only and ...
GOLD gRNA - allows robust genome editing regardless of spacer sequence composition by super stable hairpin technology
Ref.-Nr.: 1306-6101-LI
Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien
A Cas nuclease such as Cas9 can introduce a DNA double strand break in a sequence target that is complementary to a 20-nt spacer sequence of its bound guide RNA (gRNA) when a protospacer adjacent motif (PAM) is present. The gRNA can be provided as duplex of spacer containing CRISPR RNA (crRNA) and trans-activating crRNA (tracrRNA). Or as a single gRNA (sgRNA) where crRNA and tracrRNA are fused by an artificial loop.
Hence a gRNA consists of the target-specific spacer and a constant part typically ...
LITESEC - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
Ref.-Nr.: 0706-5707-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Arzneimittel-Darreichung
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.
Monoclonal Antibody to Detect Neutrophil Extracellular Traps via a Novel Post Translational Histone Modification
Ref.-Nr.: 0305-5699-LI
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Antikörper
A novel tool to detect and quantify NETs using a molecular feature of NET formation that has never been proposed as a marker for NETs before
Mouse model for mitochondrial diseases
Ref.-Nr.: 1013-4827-IKF
Medizin : Tiermodelle
Forschungs-Reagenzien
A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.
New KDAC assay and selection system
Ref.-Nr.: 0803-5480-IKF
Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

We present an extremely sensitive, reliable and fast novel Lysine deacetylase (KDAC) assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion.
We furthermore offer a bacterial selection system that can help engineer KDACs. The selection system uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby ...
Novel antiviral therapy against HIV-1 and alphaviruses: reducing frameshifting by increasing tRNALeu concentrations
Ref.-Nr.: 0707-5639-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression
Novel biomarker for diagnosis and targeted therapy of Acute Myeloid Leukemia (AML)
Ref.-Nr.: 0204-6248-MG
Medizin : Diagnostika
New biomarker candidates for diagnostic sub-classification of AML patients with elevated expression of mitochondrial proteins and subsequent targeted therapy with BCL-2 inhibitors like venetoclax and/or agents targeting mitochondrial complex I
Weiterlesen … Novel biomarker for diagnosis and targeted therapy of Acute Myeloid Leukemia (AML)
Novel Biomarkers for Ageing and Metabolic Health
Ref.-Nr.: 1013-5354-IKF
Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.
Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...
Weiterlesen … Novel Biomarkers for Ageing and Metabolic Health
Overcoming disease persistence in myeloproliferative neoplasms (MPN) through combinatorial inhibitor treatment
Ref.-Nr.: 0204-5895-MG
Medizin : Therapeutika
The mRNA processing factor YBX1 is a novel target in Myeloproliferative neoplasms (MPNs), which in an combinatorial inhibitor treatment with JAK inhibitors completely overcomes disease persistance.
Ultracompact medical ventilation system
Ref.-Nr.: 0901-6012-WT
Medizin
Sensoren, Geräte und Komponenten

The invention relates to a new, ultracompact non-invasive medical ventilation system. The BIPAP (Biphasic Positive Airway Pressure) ventilation unit, of size and weight of a tennis ball, is easy to handle and allows low-budget mass production. It can be powered by a rechargeable battery-pack – a great advantage in case of mobile use or damaged/unstable infrastructure leading to frequent blackouts. These benefits, ...
Xenorhodopsin - a new inward-directed proton pump for an alternative optogentic approach
Ref.-Nr.: 0601-5295-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues, and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...