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Cell-Penetrating Fluorescent Dyes with Secondary Alcohol Functionalities

Ref.-Nr.: 0707-5236-BC

Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. The availability and the proper choice of the dye is a key factor to success of the entire labelling and imaging procedure. Due to superior brightness and photostability, synthetic dyes often represent an attractive alternative to fluorescent proteins.

Among the multitude of fluorophores reported so far, only rhodamines, carbopyronines, and silicon-rhodamines bearing a carboxyl ...

Digital scanner

Ref.-Nr.: 0105-5505-BC

Bildgebung und Mikroskopie

Light microscopy enables fascinating insights into the microcosm of life. It is one of the key techniques in life science and provides access to a better understanding of biology across many orders of magnitude in time and space. The use of visible light allows for minimally invasive imaging - even of living cells - and direct observation with the human eye. However, the use of visible light limits the resolution of the image obtained to about half the wavelength of the used light. The limiting ...

DISPLAY IN CONDITIONS OF BRIGHT AMBIENT LIGHT

Ref.-Nr.: 1305-5612-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Dynamic Parallel Imaging: New Method for Accelerated MR Imaging

Ref.-Nr.: 0107-5654-BC

Bildgebung und Mikroskopie

The invention relates to a new method to reduce acquisition time in MR imaging. It is based on the variation of the sensitivity profile of the RF coils and allows an easy access to an additional source of spatial information to further improve imaging.
MR imaging is among the most important tools for modern medical diagnostics with a unique range of applications. The imaging duration however limits the applicability for situations with movements within the volume of interest. Therefore, many ...

Electron Microscopy: Ready to Use AI for Focus and Astigmatism Adjustment

Ref.-Nr.: 0202-6337-BC

Bildgebung und Mikroskopie

The invention relates to a new method for imaging setting optimization for electron microscopy
based on deep learning. The AI is a robust and simple to implement optimization possibility for
direct operation with various types of electron microscopes.

For a wide spectrum of applications automated precision electron microscopy is a powerful
method. Existing auto focusing routines are often based on physical models of the microscope
and are hence lacking general applicability ...

Fabrication of ultrathin nano-porous membranes and semiconductor nanowires

Ref-Nr.: 0104-4458-GÖ

Bildgebung und Mikroskopie
Neue Materialien

Semiconductor nanowires are of vital importance for many applications, such as flexible electronics, photonics, sensors, and energy harvesting and storage devices. As standard fabrication procedure, vapor-liquid-solid (VLS) growth employs metal catalyst particles (such as gold) as seeds for growth of nanowires. The seeds are deposited on a solid substrate, melted by heating and then exposed to a gas atmosphere containing source materials of the semiconductor. When the metal droplets are supersaturated, ...

Faster Processing: Neural Network for MR Imaging Parameter Prediction

Ref.-Nr.: 0107-6054-BC

Bildgebung und Mikroskopie

The invention relates to a new method for processing magnetic resonance (MR) data based on a neural network (NN). After training, the NN quickly delivers high quality CEST images with low computational effort. Additionally, it provides uncertainty data aiding to judge the images appropriately.

Typically, sophisticated MR contrasts are calculated based on complex mathematical models, which is computationally expensive, and it requires long processing durations. Besides that, the results ...

Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)

Ref.-Nr.: 0707-4198-BC

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) is nowadays a leading mo¬dality for diagnostic imaging with about 100 million examinations per year worldwide. However, when invented by Paul Christian Lauterbur in 1973, MRI was too slow to allow for routine medical applications. A breakthrough was achieved in 1985 by the FLASH (Fast Low Angle Shot) technique developed by Jens Frahm and his team at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Germany. With FLASH the measuring time for a cross-sectional ...

LABEL-FREE SEPARATION AND ANALYSIS OF MACROMOLECULES

Ref.-Nr.: 1629-4734-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten
Photonics

Method for the Calibration of a Microscope Setup

Ref.-Nr.: 1201-5661-BC

Bildgebung und Mikroskopie

Errors in super-resolution microscopy (SRM) can be identified with pairs of emitters that have fixed and precisely known relative positions. Such reference and calibration structures are exceedingly rare on the nanoscale. Here, Nitrogen-vacancy centers in diamond (NVs) offer a formidable solution. These fluorescent defects are photo-stable and due to the excellent properties of their brilliant host, do not diffuse and are resilient against temperature or chemical environment changes.

On ...

Multichannel coil for UHF MRI

Ref.-Nr.: 0107-4677-BC

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Exploiting the benefits offered by magnetic resonance imaging (MRI) at ultra-high fields (≥ 7 Tesla) requires optimized radiofrequency (RF) coils. MRI at UHF operates in a regime where the RF wavelength is comparable to the dimensions of the sample size, resulting in an inhomogeneous distribution of the transmit field (B1+) and in an impaired image quality. An array of independent transmit coils arranged in multiple rows provides the degrees of freedom to influence the ...

Nanographene-based dyes as high performance probes for super-resolution microscopy

Ref.-Nr.: 0903-5658-LC; 0903-5696-LC

Analytik
Bildgebung und Mikroskopie
Neue Materialien

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).

They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.

These nanographene ...

Noise Free Imaging: Incoherent Light Source for Microscopy

Ref.-Nr.: 1629-5817-WT

Bildgebung und Mikroskopie

The invention relates to a new light source exhibiting a high level of spatial incoherence. This enables microscopic imaging with reduced artefacts and low intensity noise. It comprises a pulsed laser whose beam properties are improved is by a multimode optical fiber.
Full field microscopic imaging is an essential technique in medicine and beyond, but the occurrence of noise strongly limits its applicability. Coherent light contributes considerably to the formation of artefacts. Hence the ...

Parallel-imaging time-of-flight momentum microscope

Ref.-Nr.: 1401-4572-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten : Geräte

The state of an electron is completely defined by its momentum and spin. In processes like electron diffraction or photoemission electron ensembles are generated which have a characteristic 3D distribution of momentum and spin. To examine such events the three components of the momentum vector have to be measured. Up to now, the momentum distribution of an ensemble of charged particles was typically measured using energy-dispersive spectrometers based on sequential approaches (sequentially changing ...

PONy Dyes – Fluorescent Dyes with Phosphorus Substituents

Ref.-Nr.: 0707-5297-BC

Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. In particular, the sensitive and stable imaging of cellular components depends on the favourable combination of chemical, biological and physical factors. The availability and proper choice of fluorescent dyes is a key factor to success in the entire labelling and imaging procedure. Due to their superior brightness and photostability, synthetic dyes represent an attractive alternative ...

Precision Microscopy: Detector for Changes in Direction of a Light Beam

Ref.-Nr.: 0105-5623-BC

Bildgebung und Mikroskopie

The invention relates to a new method for light beam angle detection that is based on interferometry. High precision and sensitivity for slight changes of the beam direction can be achieved with this method.
For high precision light microscopy, the light beam must be aligned accurately, and the beam direction stability must be ensured in order to maintain a sufficient imaging resolution over longer periods of time. In standard microscopy environments even small temperature changes can result ...

Simultaneous multi-color fluorescence microscopy with improved spatio-temporal resolution and image contrast

Ref.-Nr.: 0707-5644-BC

Bildgebung und Mikroskopie

Fluorescence microscopy is one of the key techniques in the life and materials sciences, with applications ranging from routine diagnostics to state-of-the-art research investigations. Key to this success has been its intrinsic advantages combined with continuous improvement in its fundamental features such as resolution, speed, and sensitivity.


Two key challenges are fast single-fluorophore imaging of multi-color samples. This need arises in a broad range of settings such as very high-resolution ...