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Adaptive Optics Innovations for High Resolution Microscopy and Material Science
Ref.-Nr.: 2022-6510-6511-6512-BC
Bildgebung und Mikroskopie
This offer presents three cutting-edge technologies for adaptive optics in microscopy, each covered by a distinct patent family: WO2021204663A1, WO2022018002A1, and WO2022223695A1. These innovations utilize spatial light modulators and machine learning, particularly neural networks, to address and correct optical distortions in real-time. They are as well applicable for a broader range of scenarios where precise light delivery is required, and hindered by aberrating conditions, such as for microfabrication ...
Weiterlesen … Adaptive Optics Innovations for High Resolution Microscopy and Material Science
Advanced Multichannel Coil for Ultra-High Field MRI
Ref.-Nr.: 0107-4677-BC
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten
This technology introduces a multichannel radiofrequency (RF) coil setup for ultra-high field (UHF) magnetic resonance imaging (MRI) at ≥7 Tesla. Designed for optimal imaging of the human brain, the system combines a 16-channel dual-row transmit array with a 31-channel receive array. It addresses the challenges of uneven signal distribution (B1+ field inhomogeneities) and enhances signal-to-noise ratio (SNR) through innovative RF shimming and tightly coupled coil configurations. ...
Weiterlesen … Advanced Multichannel Coil for Ultra-High Field MRI
Cryo-Light Microscope and Immersion Medium for Cryo-Light Microscopy
Ref.-Nr.: 0707-5496-BC
Bildgebung und Mikroskopie

Cryogenic fluorescent light microscopy of flash-frozen cells presents significant advantages and provides an important complement to electron cryo-microscopy. In particular, bleaching decreases drastically at low temperature while the fluorescence yield of many fluorophores increases and the spectral bands narrow. The application of modern super-resolution methods such as STED, PALM, STORM, or SIM at cryogenic temperature holds the prospect of imaging fluorescent proteins with high precision in ...
Weiterlesen … Cryo-Light Microscope and Immersion Medium for Cryo-Light Microscopy
Device and method for creating an optical tomogram of a living microscopic sample
Ref.-Nr.: 1402-4889-BC
Analytik
Bildgebung und Mikroskopie
This technology describes a method and device for generating optical tomograms of microscopic samples using an advanced imaging process. The method involves rotating and displacing a sample within an optical microscope’s focal plane to capture a series of images from multiple angles. These images are subsequently processed to create a detailed three-dimensional model of the sample. The innovation reduces motion stress on living samples and minimizes the time required for tomogram acquisition. ...
Weiterlesen … Device and method for creating an optical tomogram of a living microscopic sample
Digital scanner
Ref.-Nr.: 0105-5505-BC
Bildgebung und Mikroskopie

Light microscopy enables fascinating insights into the microcosm of life. It is one of the key techniques in life science and provides access to a better understanding of biology across many orders of magnitude in time and space. The use of visible light allows for minimally invasive imaging - even of living cells - and direct observation with the human eye. However, the use of visible light limits the resolution of the image obtained to about half the wavelength of the used light. The limiting ...
DISPLAY IN CONDITIONS OF BRIGHT AMBIENT LIGHT
Ref.-Nr.: 1305-5612-WT
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Dynamic Parallel Imaging: Accelerated MRI through Sensitivity Profile Modulation
Ref.-Nr.: 0107-5654-BC
Bildgebung und Mikroskopie

This invention presents a novel method to accelerate Magnetic Resonance Imaging (MRI) by dynamically modulating the sensitivity profiles of RF receive coils. Traditional MRI methods rely on fixed sensitivity profiles, limiting the speed of acquisition. The new approach introduces time-dependent modifications, enabling access to additional spatial information for faster and higher-resolution imaging. By employing adjustable electronic components such as varactor diodes or metamaterials, the method ...
Weiterlesen … Dynamic Parallel Imaging: Accelerated MRI through Sensitivity Profile Modulation
Electrochemically-Controlled Metasurfaces for High-Contrast, Fast-Switching Optical Applications
Ref.-Nr.: 1201-6070-BC
Prozesse und Methoden (inkl. Screening)
Bildgebung und Mikroskopie

This invention introduces an advanced optical component based on electrochemically-controlled metasurfaces. These metasurfaces, designed for high-contrast switching at visible frequencies, combine ultrathin, planar structures with precise light manipulation capabilities. The core innovation leverages a repeating array of unit cells containing two different scattering structures. These structures contain materials of varying refractive indices, which are tunable through an external control signal. ...
Electron Microscopy: Deep Learning-Based Autofocus and Astigmatism Correction
Ref.-Nr.: 0202-6337-BC
Bildgebung und Mikroskopie

This invention presents a novel AI-based method for optimizing imaging settings in electron microscopy, specifically targeting autofocus and astigmatism correction. By applying deep learning, the system rapidly estimates and adjusts key imaging parameters in real time, significantly enhancing both image quality and efficiency. Unlike traditional physics-based approaches, this method generalizes well across different microscopes and configurations. It operates using pairs of images with known deviations ...
Weiterlesen … Electron Microscopy: Deep Learning-Based Autofocus and Astigmatism Correction
Faster Processing: Neural Network for MR Imaging Parameter Prediction
Ref.-Nr.: 0107-6054-BC
Bildgebung und Mikroskopie

The invention relates to a new method for processing magnetic resonance (MR) data based on a neural network (NN). After training, the NN quickly delivers high quality CEST images with low computational effort. Additionally, it provides uncertainty data aiding to judge the images appropriately.
Typically, sophisticated MR contrasts are calculated based on complex mathematical models, which is computationally expensive, and it requires long processing durations. Besides that, the results ...
Weiterlesen … Faster Processing: Neural Network for MR Imaging Parameter Prediction
Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)
Ref.-Nr.: 0707-4198-BC
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) is nowadays a leading mo¬dality for diagnostic imaging with about 100 million examinations per year worldwide. However, when invented by Paul Christian Lauterbur in 1973, MRI was too slow to allow for routine medical applications. A breakthrough was achieved in 1985 by the FLASH (Fast Low Angle Shot) technique developed by Jens Frahm and his team at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Germany. With FLASH the measuring time for a cross-sectional ...
Weiterlesen … Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)
High resolution full material Fresnel Zone Plate array and process for its fabrication
Ref.-Nr.: 0104-5259-GÖ-IT
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

A full material Fresnel Zone Plate is a diffractive lens, composed of multilayers of at least two materials to act as the zones of the FZP. Researchers in Max Planck Institute for Intelligent Systems developed a production method in which alternating layers over focused ion beam (FIB) milled micro pillars are first deposited using atomic layer deposition (ALD) technique and then sliced by using the FIB again.
Weiterlesen … High resolution full material Fresnel Zone Plate array and process for its fabrication
High-Resolution Scanning Luminescence Light Microscope
Ref.-Nr.: 0707-5028-BC
Bildgebung und Mikroskopie

This advanced scanning luminescence light microscope enables spatial, high-resolution imaging of luminescence-labeled structures. Utilizing innovative periodic patterns created by crossed line gratings of luminescence inhibition and excitation light, the microscope surpasses traditional diffraction limits. These patterns precisely confine the luminescent marker's activation and emission regions, delivering imaging clarity. The device is ideal for applications requiring nanoscale resolution, ...
Weiterlesen … High-Resolution Scanning Luminescence Light Microscope
LABEL-FREE SEPARATION AND ANALYSIS OF MACROMOLECULES
Ref.-Nr.: 1629-4734-WT
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten
Photonics

Weiterlesen … LABEL-FREE SEPARATION AND ANALYSIS OF MACROMOLECULES
Microfluidic cryo-fixation of biomass, e.g., cells, flagella/cilia, or proteins for (in particular) correlative light-electron microscopy systems
Ref.-Nr.: 0707-4032-BC
Bildgebung und Mikroskopie

Cryo-Electron Microscopy (Cryo-EM) today is revolutionizing biological research by revealing the structure of cells and proteins with atomic resolution and steadily improving contrast. However, the quality of the results depends critically on the sample preparation. High Pressure Freezing (HPF) and plunge freezing, both pioneered in the 1960s, still represent the state-of-the-art in sample preparation for cryo-EM. Both methods have poor timing precision, disrupt the natural environment of the ...
MINSTED fluorescence localization and nanoscopy
Ref.-Nr.: 0707-6171-BC
Bildgebung und Mikroskopie

The MINSTED method is an innovative technique for determining the position of a singularized fluorophore molecule within an object. Traditional methods in molecular imaging faced challenges in achieving high resolution due to limitations in fluorescence microscopy. Existing solutions like STED (Stimulated Emission Depletion) microscopy improved the spatial resolution but rely on high illumination intensity and/or sample exposure, which can lead to thermal issues and photochemical reactions. MINSTED ...
Weiterlesen … MINSTED fluorescence localization and nanoscopy
MR Imaging Using Localized Oscillating Magnetic Fields
Ref.-Nr.: 0107-5557-BC
Bildgebung und Mikroskopie

A novel Magnetic Resonance Imaging (MRI) method accelerates imaging by using localized, time-varying magnetic fields to enhance spatial encoding. This approach involves small coils placed around the imaging object, generating oscillating magnetic fields with adjustable frequencies and phases. These modulations provide additional spatial information, enabling faster image acquisition while maintaining high resolution and signal quality. The method integrates with parallel imaging techniques, reducing ...
Weiterlesen … MR Imaging Using Localized Oscillating Magnetic Fields
Nanographene-based dyes as high performance probes for super-resolution microscopy
Ref.-Nr.: 0903-5658-LC; 0903-5696-LC
Analytik
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Neue Materialien

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).
They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.
These nanographene ...
Weiterlesen … Nanographene-based dyes as high performance probes for super-resolution microscopy
Noise Free Imaging: Incoherent Light Source for Microscopy
Ref.-Nr.: 1629-5817-WT
Bildgebung und Mikroskopie

The invention relates to a new light source exhibiting a high level of spatial incoherence. This enables microscopic imaging with reduced artefacts and low intensity noise. It comprises a pulsed laser whose beam properties are improved is by a multimode optical fiber.
Full field microscopic imaging is an essential technique in medicine and beyond, but the occurrence of noise strongly limits its applicability. Coherent light contributes considerably to the formation of artefacts. Hence the ...
Weiterlesen … Noise Free Imaging: Incoherent Light Source for Microscopy
Parallel-imaging time-of-flight momentum microscope
Ref.-Nr.: 1401-4572-WT
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten : Geräte

The state of an electron is completely defined by its momentum and spin. In processes like electron diffraction or photoemission electron ensembles are generated which have a characteristic 3D distribution of momentum and spin. To examine such events the three components of the momentum vector have to be measured. Up to now, the momentum distribution of an ensemble of charged particles was typically measured using energy-dispersive spectrometers based on sequential approaches (sequentially changing ...
Weiterlesen … Parallel-imaging time-of-flight momentum microscope
Photoactivable fluorescent dyes with hydrophilic caging groups and their use
Ref.-Nr.: 0707-6050-BC
Bildgebung und Mikroskopie
This invention presents a series of photoactivatable fluorescent dyes characterized by their hydrophilic caging groups. These novel compounds are primarily designed for bioimaging applications, allow for controlled photoactivation at the desired wavelengths and exhibit enhanced solubility in aqueous environments. The technology facilitates high-precision imaging techniques, including super-resolution fluorescence microscopy and single-molecule tracking, by enabling precise spatial and temporal ...
Weiterlesen … Photoactivable fluorescent dyes with hydrophilic caging groups and their use
PONy Dyes – Fluorescent Dyes with Phosphorus Substituents
Ref.-Nr.: 0707-5297-BC
Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. In particular, the sensitive and stable imaging of cellular components depends on the favourable combination of chemical, biological and physical factors. The availability and proper choice of fluorescent dyes is a key factor to success in the entire labelling and imaging procedure. Due to their superior brightness and photostability, synthetic dyes represent an attractive alternative ...
Weiterlesen … PONy Dyes – Fluorescent Dyes with Phosphorus Substituents
Precision Microscopy – Interferometric Detector for Light Beam Angle Deviations
Ref.-Nr.: 0105-5623-BC
Bildgebung und Mikroskopie

This invention presents a novel, interferometry-based method for detecting angular changes in light beams with extremely high sensitivity and robustness. Developed for high-precision microscopy, it enables stable and long-term beam alignment by measuring even minute directional deviations that can occur due to environmental fluctuations such as temperature changes. The technique splits the incoming light beam into two paths that interfere with one another on a camera sensor, generating an interference ...
Weiterlesen … Precision Microscopy – Interferometric Detector for Light Beam Angle Deviations
Processing Magnetic Resonance Data via Machine Learning-Enhanced Non-Linear Regression
Ref.-Nr.: 0107-5583-BC
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

This invention describes an advanced method and apparatus for processing magnetic resonance (MR) data, integrating machine learning to address key challenges in MR imaging analysis. The process involves collecting MR data, applying a machine learning model to estimate initial parameters, and refining these through regression to generate precise parameter maps (e.g., T1/T2 relaxation times, CEST metrics). This technology enhances the speed, accuracy, and reliability of diagnostic imaging applications, ...
Weiterlesen … Processing Magnetic Resonance Data via Machine Learning-Enhanced Non-Linear Regression
Reliable and Independent: New Automated Glaucoma Detection Method
Ref.-Nr.: 0705-5468-BC
Bildgebung und Mikroskopie

The invention relates to a newly developed image processing method for optical coherence tomography (OCT) to be used in particular on the (human) eye’s anterior chamber. Said OCT images are used to diagnose glaucoma, but the required assessing methods are not yet available as automated and fully unsupervised.
Glaucoma is the main reason for irreversible blindness. Early-stage diagnosis is typically based on images of the anterior chamber. Various automated techniques for image analysis ...
Weiterlesen … Reliable and Independent: New Automated Glaucoma Detection Method
Simultaneous Multi-Color Fluorescence Microscopy with Enhanced Spatio-Temporal Resolution
Ref.-Nr.: 0707-5644-BC
Bildgebung und Mikroskopie

This invention, developed jointly by the KU Leuven and the Max-Planck-Society, introduces a novel optical module enabling simultaneous multi-color fluorescence microscopy with single-molecule sensitivity and significantly improved throughput. Designed for easy integration with existing microscopy setups, the module utilizes a fully reflective optical system to encode emission color into spatial image features. Combined with advanced image processing algorithms, the system allows researchers to ...
Technique for calibrating and processing magnetic resonance imaging data
Ref.-Nr.: 0107-6771-BC-0107-6772-BC
Bildgebung und Mikroskopie

Two groundbreaking technologies are introduced, offering substantial enhancements to the precision and efficiency of Magnetic Resonance Imaging (MRI) by auto-calibrating spin phase information directly from imaging data.
The first invention presents a method to extract spin phase evolution maps – arising from arbitrary spatial encoding fields that continuously oscillate and evolve during signal acquisition – using existing imaging data without the need for additional field mapping scans. ...
Weiterlesen … Technique for calibrating and processing magnetic resonance imaging data
Ultrarapid cryo-fixation during live observation on a fluorescence microscope
Ref.-Nr.: 0803-6035-IKF
Bildgebung und Mikroskopie

A ultrarapid cryo-arrest directly on a multimodal fluorescence microscope that preserves molecular activity patterns during observation of their dynamics in living cells at any timepoint.
Weiterlesen … Ultrarapid cryo-fixation during live observation on a fluorescence microscope