Analytik

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A system-wide approach for the identification of druggable proteins in a complex mixture

Ref.-Nr.: 0402-5163-MG

Analytik

In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...

Automated real time determination of crystal size and 3D shape distribution to quantify and predict the properties and dynamics of the crystallization processes

Ref.-Nr.: 1402-5690-LC

Analytik
Prozesse und Methoden (inkl. Screening)

To monitor crystallization processes a special camera setup to measure the crystal size and 3D shape distribution was developed.
The setup consists of two high-speed cameras that are positioned orthogonally to one another such that a precise overlap of both fields of view can be achieved. The setup further contains a specially designed flow-through cell that allows to observe the crystal suspension from both camera directions and given the opportunity to temperate the solution within the cell. ...

BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control

Ref.-Nr.: 1200-3727 GÖ

Analytik

BiQ Analyzer is a software tool for easy visualization and quality control of DNA methylation data. With more than a thousand users worldwide, BiQ Analyzer has become a standard tool for processing DNA methylation data from bisulfite sequencing. BiQ Analyzer has been selected by ABI to be part of the Applied Biosystems Software Community Program.

Dynamic control of three-dimensional light distributions through wavefront engineering: hardware and software system

Ref.-Nr.: 0202-5001-LI

Analytik
IT / Software / Bioinformatik

Engineering light distributions in a three-dimensional volume to achieve selective illumination profiles is an instrumental task shared by many optical and microscopy techniques. The optimization of the light distribution can lead to significant enhancement of relevant performance figures and ultimately to the extension of the instrument or experimental protocol capabilities1,2,3,4,5. Targeted illumination profiles can be used either to mechanically interact with molecules at nanometer ...

Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity

Ref.-Nr.: 1013-4990-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.

Nanocapsule suitable for non-invasive simultaneous oxygen content and temperature sensing in a living object

Ref.-Nr.: 0903-4972-LC-WA

Analytik
Sensoren, Geräte und Komponenten

Simultaneous sensing of oxygen content and temperature within a living object is crucial to monitor its biochemical reactions and to evaluate its health condition. Non-invasive sensors used for this purpose feature optical read-out. These sensors detect changes in phosphorescence (decay time or emission intensity) of a phosphorescent compound and the delayed fluorescence intensity of a fluorescent compound induced by an increase of temperature and/or oxygen. Unfortunately, the temperature and ...

Nanographene-based dyes as high performance probes for super-resolution microscopy

Ref.-Nr.: 0903-5658-LC; 0903-5696-LC

Analytik
Bildgebung und Mikroskopie
Neue Materialien

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).

They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.

These nanographene ...

New KDAC assay and selection system

Ref.-Nr.: 0803-5480-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

We present an extremely sensitive, reliable and fast novel Lysine deacetylase (KDAC) assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion.

We furthermore offer a bacterial selection system that can help engineer KDACs. The selection system uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby ...

Novel Biomarkers for Ageing and Metabolic Health

Ref.-Nr.: 1013-5354-IKF

Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...

Novel method for analysis of complex carbohydrate structures by ion-mobility mass spectrometry (IM-MS)

Ref.-Nr.: 0401-5070-MG

Analytik

Carbohydrates form one of the major classes of biological macromolecules in living organisms, but structural analysis and the quality control of carbohydrate structures represent a major challenge due to the frequent occurrence of isomers that are difficult to distinguish using established techniques.

Changes in protein glycosylation are frequently identified in the context of diseases. For example, alterations in N-glycan profiles from blood plasma have been found to correlate with pathological ...

Ray Casting Algorithm (RCA) for Unprecedented Bone Segmentation Analysis

Ref.-Nr.: 1306-4111-LI

Analytik
IT / Software / Bioinformatik

In the last decade, high-resolution computed tomography (CT) and microcomputed tomography (micro-CT) have been increasingly used in anthropological studies and as a complement to traditional histological techniques. This is due in large part to the ability of CT techniques to nondestructively extract three-dimensional representations of bone structures. Despite prior studies employing CT techniques, no completely reliable method of bone segmentation has been established.

Simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples

Ref.-Nr.: 0105-5434-IKF

Analytik

A simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples, with various applications such as enzymatic assays, clinicals tests, and as point of care tests in the field of ageing.

Stable, site-specific conjugation of His-tagged proteins via cobalt (III) carbonate reagents

Ref.-Nr.: 0105-5774-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

This invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier.