Technologieangebote

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Analytik

IT / Software / Bioinformatik

Prozesse und Methoden (inkl. Screening)

Medizin

Forschungs-Reagenzien

Nukleinsäure-, Protein-, Zell-bezogene Technologien

Grüne Biotechnologie

Bildgebung und Mikroskopie

Neue Materialien

Sensoren, Geräte und Komponenten

Photonics

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Treffer

A genetically conserved and transferable defense mechanism protects plants from herbivores

Ref.-Nr.: 1602-6322-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Grüne Biotechnologie

Our scientists have identified a conserved defense mechanism covering a new metabolite in tobacco that protects against leafhoppers. They have discovered how to reconstitute it in vitro and engineer the compound in crop plants, demonstrating that it confers resistance to herbivores.

A graphene diode with bias-induced barrier modulation

Ref.-Nr.: 1201-5155-BC

Sensoren, Geräte und Komponenten

Metal-insulator-metal (MIM) diodes are very promising for application as rectennas for solar energy harvesting, photo-detectors and high frequency mixers. Good MIM diode performance requires a high asymmetry, a strong nonlinearity, a large responsively, as well as a low resistance or a high on-current. These figures of merit are mainly determined by the work function difference of the electrodes, and the barrier height between the insulator and the electrode materials. In the design of MIM diodes, ...

A high-throughput compatible workflow for generation and analysis of homogenous human neural microtissues

Ref.-Nr.: 1012-5677-LI

Prozesse und Methoden (inkl. Screening)

File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)

A robust method for producing and analyzing highly homogenous human neural organoids.

A method and device for reversibly attaching a phase changing metal to an object

Ref.-Nr.: 0104-5132-BC

Sensoren, Geräte und Komponenten

Reversible adhesion can be used to transfer or to manipulate objects. Especially if the objects are small and/or fragile their manipulation become very challenging. Intermolecular forces such as Van-der-Waals can be used to achieve a strong adhesion between the objects. Moreover, surface functionalization and the creation of nano- and microstructures can be used to improve these adhesion properties. Unfortunately, the adhesion becomes insufficient if the surfaces are wet or rough. Another problems ...

A method for the production of plants with altered photorespiration and improved CO2 fixation

Ref.-Nr.: 0706-5666-IKF

Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Grüne Biotechnologie

Recently, many efforts have been made to improve growth and yield of crop plants. CO2 fixation in plants is primarily catalyzed by the enzyme ribulose-1,5-bisphosphate carboxylase (Rubisco). The inherent inefficiency of Rubisco necessitates an additional metabolic process termed photorespiration, which results in the loss of carbon and energy. In fact, it has been estimated that plants lose approximately 25% of the fixed carbon due to photorespiration. Despite several attempts to improve ...

A novel biomarker for a reliable diagnosis of colorectal cancer based on differentially methylated genomic regions

Ref.-Nr.: 0301-4550-LI

Medizin : Diagnostika

With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...

A novel class of herbal compounds saiginols with strong UV-B absorbing properties

Ref.-Nr.: 0402-4816-MG

Grüne Biotechnologie

UV-B radiation is a major damaging agent causing damage to plants, tissues and human or animal skin upon exposure. To persist strong UV-B radiation plants produce additional antioxidant sunscreen pigments that belong to the chemical compound family of phenylpropanoids. Since many conventional compounds with sunscreen protection potential do not enter the market due to toxic side effects or they bear the risk to become environmental pollutants when accumulating in natural resources, application ...

A novel inhibitor targeting matrix accumulation in cancer

Ref.-Nr.: 0105-5855_1-IKF

Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...

A novel inhibitor targeting matrix accumulation in fibrosis

Ref.-Nr.: 0105-5855_2-IKF

Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...

A novel type of influenza A virus-derived Defective interfering Particle for antiviral therapy

Ref.-Nr.: 1402-5459-BC

Forschungs-Reagenzien : Antikörper

Human influenza A virus (IAV) is responsible for seasonal disease in people and can cause worldwide pandemics. The main lines of defense against IAV are vaccines and antiviral drugs.

Influenza vaccines, including killed and live vaccines, recombinant virus-like particles and viral particles, have been available commercially for many years. Typically, the composition of influenza vaccines is based on the major influenza virus strains causing infection in the previous season. Accordingly, ...

A process for recycling of noble metals

Ref.-Nr.: 0041-5034-WT

Prozesse und Methoden (inkl. Screening)

Noble metals are used in various fields of application such as catalysis, jewelry, high technology electronic equipment, equipment for glass industry and many others. As noble metals are rare and hard to extract from the ores or exhausted compounds, many efforts have been undertaken to establish an efficient recycling process. Due to their corrosion resistant properties, noble metals recycling by means of dissolution is limited to the usage of very reactive and harmful chemicals such as Aqua Regia. ...

A system-wide approach for the identification of druggable proteins in a complex mixture

Ref.-Nr.: 0402-5163-MG

Analytik

In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...

A tunable cohesive granular material

Ref.-Nr.: 0705-5158-BC

Neue Materialien

For sieving and separation purposes porous materials with adjustable sizes and shapes of the pores as well as tunable mechanical properties are required. The existing materials such as sintered materials, open-cell foams or cemented aggregates can be made porous but they are either fragile or can collapse for large deformation. Therefore, chemically inert and damage resistant porous materials with adjustable permeability as well as mechanical and geometrical properties that can sustain large deformation ...

Accurate contactless measurement of surface and micro sample temperatures

Ref.-Nr.: 0041-5601-WT

Sensoren, Geräte und Komponenten

The study of mechanical properties of materials at high temperatures at the microstructural length scale requires dedicated testing setups. An accurate measurement of the sample temperature is vital for reliable testing. Most of the successful current testing platforms record the temperatures of the sample and tip near the heating sources but not at the respective surface. As a consequence, due to spatial and temporal thermal gradients a reliable surface temperature cannot be measured today. Even ...

Advanced collector sweeping with homogenous power deposition of the electron beam in high-power rf vacuum-tubes

Ref.-Nr.: 1801-3749-WT

Sensoren, Geräte und Komponenten

This invention includes two alternative advanced methods to achieve a homogenous collector power distribution, which improves the collector capability of high power vacuum-tubes by a factor of two as compared to conventional methods. Furthermore the applied method has a high flexibility to vary the power distribution over a wide range of profiles and match the deposition profiles to different designs of collectors in existing or future electron tubes.

Advanced magnetic zipper for industrial and consumer applications

Ref.-Nr.: 0705-4974-BC

Sensoren, Geräte und Komponenten

Conventional mechanical zippers find manifold applications for luggage, clothing or even industrial applications. However, their design features significant disadvantages. In particular, they require the use of both hands by the user to align the ends of the garment and lock the insertion pin into the slider. This mechanism can be prone to jamming and failure and more generally requires the user to free his or her hands. The user must further use one or both hands to move the slider along the ...

Advanced vorticity measurements on complex flows

Ref.-Nr.: 0705-4770-BC

Sensoren, Geräte und Komponenten

The dynamics of complex flows and turbulences are dominated by vortices of many different scales. In general, the vortex describes the group motion of fluid elements in a circular fashion, whereas the vorticity quantizes this spinning moment of a fluid element confined to a small neighborhood.

For diagnosis of flows, conventional techniques track the movements of small particles added into the flow (e.g., Lagrangian particle tracking, LPT, and particle image velocimetry, PIV). However, ...

Air-stable binary Ni(0)–olefin (pre)catalyst

Ref.-Nr.: 0042-5881-LC

Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

A family of 16-electron binary Ni(0)-stilbene complexes Ni(Rstb)3 as a new class of air-stable Ni(0) (pre)catalysts was developed.

Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia

Ref.-Nr.: 0305-3252-LI

Medizin : Therapeutika

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...

Anti-breaking Superhydrophobic and Photocatalytic Active Films used as Blood Repellent Dressing

Ref.-Nr.: 0903-5907-LC

Medizin
Neue Materialien

Highly elastic, photocatalytic active, and superhydrophobic films were prepared by self-assembly of TiO2 nanoparticles driven by crosslinking reactions of PDMS. The photocatalytic activity of the film provides self-cleaning and antibacterial properties when exposed to UV-A light. Substrates of different materials such as glass, PU, and polyester textiles can be easily modified with the film. The corresponding PDMS/TiO2 film based wound dressings can effectively block leakage ...

Anti-mouse and anti-rabbit IgG secondary VHH single domain antibodies optimized for all immuno-labeling applications

Ref.-Nr.: 0707-5419-LI

Neue Materialien

Anti-IgG secondary antibodies are major tools for the detection or immobilization of primary antibodies in approaches such as western blotting, ELISA, Co-IP and immunofluorescence. Polyclonal anti-IgG secondary antibodies are produced in animals, such as mouse, rabbit, rat, and goat and are directed against the IgG classes of these animals. Thus, the generation of such secondary antibodies requires the keeping and use of a large number of animals, which is not only costly but also a major ethical ...

Apparatus and method for creating a holographic ultrasound field in an object

Ref.-Nr.: 0104-5066-BC

Sensoren, Geräte und Komponenten

Ultrasound is being used in many fields ranging from medical imaging and therapy to non-destructive testing, contact-free particle handling or spatially selective heating in industrial settings. Often, those applications require shaping (including focusing) of an ultrasonic field. Compared to existing transducers with fixed lenses or phased array transducers (PATs) the present invention allows much more sophisticated sound fields to be generated using much simpler and cheaper technology.

Application of novel channelrhodopsins: molecular engineering, site-specific opsin targeting, discovery of new variants and the advancement in optogenetic devise development

Ref.-Nr.: 0601-4259-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...

Automated real time determination of crystal size and 3D shape distribution to quantify and predict the properties and dynamics of the crystallization processes

Ref.-Nr.: 1402-5690-LC

Analytik
Prozesse und Methoden (inkl. Screening)

To monitor crystallization processes a special camera setup to measure the crystal size and 3D shape distribution was developed.
The setup consists of two high-speed cameras that are positioned orthogonally to one another such that a precise overlap of both fields of view can be achieved. The setup further contains a specially designed flow-through cell that allows to observe the crystal suspension from both camera directions and given the opportunity to temperate the solution within the cell. ...

BALSAC: Build and Analyze Lattices, Surfaces, And Clusters

Ref.-Nr.: 0302-1508-LC

IT / Software / Bioinformatik

PC-based software to construct lattice sections and clusters/molecules with extended graphical display and analysis options.

Bioinspired Liquid-Superrepellent Fibrillar Dry Adhesives

Ref.-Nr.: 0104-5929-GÖ

Neue Materialien

Since 2000 bioinspired fibrillar dry adhesives have been studied intensively culminating in commercial products already available on the market. Currently known fibrillar adhesives are fully wetted by oils, leading to significantly decreased adhesion and friction performance. Therefore, a high demand exists for reversible dry fibrillar adhesives that can repel oil-like liquids and adhere strongly to surfaces wetted by them.

To meet the aforementioned challenges, an extraordinary fibrillar ...

BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control

Ref.-Nr.: 1200-3727 GÖ

Analytik

BiQ Analyzer is a software tool for easy visualization and quality control of DNA methylation data. With more than a thousand users worldwide, BiQ Analyzer has become a standard tool for processing DNA methylation data from bisulfite sequencing. BiQ Analyzer has been selected by ABI to be part of the Applied Biosystems Software Community Program.

Borylated Pyrenes and Terrylenes as blue and green emitters

Ref.-Nr.: 0903-5692-LC

Neue Materialien

Prof. Klaus Müllen an co-workers at the Max-Planck-Institute for Polymer Research developed a straightforward C-H borylation at the 2- and 2,7-positions of pyrene derivatives. The small neutral organic molecules show sharp fluorescence emission peeks between 400-550 nm and high photoluminiscense quantum yields.

Bottom-up assembly of synthetic extracellular vesicles for biomedical applications

Ref.-Nr.: 0105-5888-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Prozesse und Methoden (inkl. Screening) : Produktion
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Natural extracellular vesicles (EVs) are lipid vesicles that carry a plethora of biologically active molecules including soluble and membrane proteins, nucleic acids and metabolites. They have recently been recognized as a promising cell-free alternative to cell transplantation or as a novel therapeutic tool in various diseases. Many in vitro and in vivo studies have shown beneficial effects of EVs from different cell types in diseases ranging from cardiovascular conditions to ...

Carbon-neutral and carbon-positive photorespiration bypass routes supporting higher photosynthetic rate and yield

Ref.-Nr. 0402-5003-MG

Grüne Biotechnologie

Carbon fixation is arguably the most important biochemical processes on earth, supporting our biosphere by transforming inorganic carbon into organic matter and literally feeding all life forms. The reductive pentose phosphate cycle (rPP, also known as the Calvin–Benson–Bassham Cycle) is responsible for ≥95% of the carbon fixed in the biosphere. Although under a strong selective pressure for eons, this process displays major inefficiencies, some are due to the low catalytic rate and the ...

Cell-Penetrating Fluorescent Dyes with Secondary Alcohol Functionalities

Ref.-Nr.: 0707-5236-BC

Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. The availability and the proper choice of the dye is a key factor to success of the entire labelling and imaging procedure. Due to superior brightness and photostability, synthetic dyes often represent an attractive alternative to fluorescent proteins.

Among the multitude of fluorophores reported so far, only rhodamines, carbopyronines, and silicon-rhodamines bearing a carboxyl ...

CellNetAnalyzer: A Software Package for Analyzing Structure and Function of Cellular Networks

Ref.-Nr. 1402-3895-LC

IT / Software / Bioinformatik

CellNetAnalyzer (CNA) is a MATLAB toolbox providing various computational methods for analyzing structure and function of metabolic, signaling, and regulatory networks. For metabolic networks, CNA supports a variety of stoichiometric and constraint-based modeling techniques, including flux balance analysis (FBA), metabolic flux analysis, elementary-modes analysis, or computational strain design (e.g., minimal cut set analysis). Signal transduction and (gene) regulatory networks can be ...

Closure Device for Evaporator Cell of a Coating System

Ref.-Nr.: 1201-5136-BC

Sensoren, Geräte und Komponenten

Evaporation cells for thin film deposition often operate under ultrahigh vacuum or special gas atmosphere, requiring long growth campaigns and short maintenance openings to preserve the best possible vacuum environment. The deposition leads to coating of the inner chamber walls, the removal of which is difficult and very time consuming. Growth control and interruptions during material deposition may require frequent operation of the closure device or shutter. The commonly used shutter (Fig. 1) ...

Compact high-voltage vacuum feedthrough

Ref.-Nr.: 0302-4988-WT

Sensoren, Geräte und Komponenten

Applying high voltages in vacuum applications requires feedthroughs, which electrically insulate the conductor from the vacuum chamber whilst being vacuum-tight. In high- and ultrahigh vacuum environments, the materials used need to be low in outgassing rates. The current technology for feedthroughs withstanding tens to hundreds of kilovolts relies on vacuum-tight ceramic to metal connections, which are heavy, fragile and prone to contamination. Commercially available feedthroughs are stand-alone ...

Core-shell catalyst design for improved heat management with highly exothermic reactions

Ref.-Nr.: 1402-5768-LC

Prozesse und Methoden (inkl. Screening)
Neue Materialien

Prof. Kai Sundmacher and co-workers at the MPI for Dynamics of Complex Technical Systems developed a novel core-shell catalyst design with a highly active catalyst core surrounded by an inert, low-permeability shell. The new catalyst design leads to an intrinsic heat management that avoids hotspots in strongly exothermic reactions. This allows faster reactor start-up and shut-down and makes the catalysts suitable for rapid load changes in discontinuous processes.

Cyclopropenylylidene-Stabilized Phosphenium Cations and their Applications in Homogeneous Catalysis

Ref.-Nr.: 0042-5177-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

We offer novel phosphenium ligands and corresponding metal complexes (both air stable) that are claimed as substances by granted EP and US patents. The ligands can be prepared in multigram scale by simple direct condensation. The corresponding gold complexes are suitable as homogeneous catalysts in organic synthesis (such as cycloisomerization) that can be easily precipitated and recycled due to their salt properties.

Decontamination of radioactive caesium in humans

Ref.-Nr.: 0042-5371-LC / SGK A477

Prozesse und Methoden (inkl. Screening)
Medizin

Prof. Klaus-Richard Pörschke and co-workers from the MPI for Coal Research developed a highly hydrophobic perfluoroaryl borate (FAB) ligand for trapping the radioative 134/137 Cs isotopes with 100% specificity. The novel approach could improve the decontamination of humans compared to the administration of so called insouble Prussian blue currently in use.

DECONV-Software

Ref.-Nr.: 1401-4358-WT

IT / Software / Bioinformatik

Das Verfahren der Lock-in-Thermographie (LIT) gestattet es, 2-dimensionale Bilder der Verteilung der in einer Probe dissipierten Leistung zu erzeugen. Allerdings sind diese Lock-in Thermogramme noch durch die unvermeidliche laterale Wärmediffusion in der Probe "verbreitert" (blurred). Das "DECONV"-Programm gestattet es, diese thermische Verbreiterung durch die Anwendung eines örtlichen Entfaltungs-Verfahrens wieder rückgängig zu machen und dadurch die effektive Ortsauflösung der Lock-in-Thermographie ...

Digital scanner

Ref.-Nr.: 0105-5505-BC

Bildgebung und Mikroskopie

Light microscopy enables fascinating insights into the microcosm of life. It is one of the key techniques in life science and provides access to a better understanding of biology across many orders of magnitude in time and space. The use of visible light allows for minimally invasive imaging - even of living cells - and direct observation with the human eye. However, the use of visible light limits the resolution of the image obtained to about half the wavelength of the used light. The limiting ...

DISPLAY IN CONDITIONS OF BRIGHT AMBIENT LIGHT

Ref.-Nr.: 1305-5612-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Dual Inhibition of plexin-B1 and plexin-B2

Ref.-Nr.: 0603-5770-IKF

Medizin : Therapeutika

A novel molecular target of the semaphorin-plexin system to develop treatment options for cancer and for osteoporosis.

Dynamic control of three-dimensional light distributions through wavefront engineering: hardware and software system

Ref.-Nr.: 0202-5001-LI

Analytik
IT / Software / Bioinformatik

Engineering light distributions in a three-dimensional volume to achieve selective illumination profiles is an instrumental task shared by many optical and microscopy techniques. The optimization of the light distribution can lead to significant enhancement of relevant performance figures and ultimately to the extension of the instrument or experimental protocol capabilities1,2,3,4,5. Targeted illumination profiles can be used either to mechanically interact with molecules at nanometer ...

Dynamic Parallel Imaging: New Method for Accelerated MR Imaging

Ref.-Nr.: 0107-5654-BC

Bildgebung und Mikroskopie

The invention relates to a new method to reduce acquisition time in MR imaging. It is based on the variation of the sensitivity profile of the RF coils and allows an easy access to an additional source of spatial information to further improve imaging.
MR imaging is among the most important tools for modern medical diagnostics with a unique range of applications. The imaging duration however limits the applicability for situations with movements within the volume of interest. Therefore, many ...

eeFILM – Extended Excitation for Faster Measurement of Fluorescent Lifetimes

Ref.-Nr.: 0707-5026-BC

Sensoren, Geräte und Komponenten

The estimation of excitation lifetimes based on fluorescence or phosphorescence emission is an essential technique in basic and applied science. It provides information on molecular interactions
as well as on physical properties. Measuring the emission lifetime with spatial resolution provides an imaging modality, which in case of fluorescence is called Fluorescence Lifetime Imaging (FLIM). FLIM is applied extensively in biological imaging in order to determine the conformation, activation, ...

Efficient cooling of commercially available electrical wiring by the use of metals with low melting temperatures

Ref.-Nr.: 1801-4852-WT

Sensoren, Geräte und Komponenten

Resistance induced heating of electrical wiring during operation is one of the limiting factors to design high-power electromagnetic coils. The commonly used approach to eliminate the heating of electrical wires is to introduce a hollow conductive copper wire into electrical wiring and to cool this wire with water. Unfortunately, this approach is not applicable for high power density electromagnetic coil as well as for coils with small dimensions. Another approach to enhance the cooling properties ...

Efficient Optical Readout: Highly Versatile Chemical Sensor

Ref.-Nr.: 0104-6343-BC

Sensoren, Geräte und Komponenten

The invention relates to an innovative detector concept for the identification of analytes in a gas that is extremely versatile and yet easy to construct and to operate. The superior properties were reached by an optical readout system for electrical signal of multiple detector cells.

Detecting and quantifying concentrations of analytes of interest is usually achieved using materials that change their electrical properties upon exposure. As different materials combined in one sensor need ...

Electroluminescence Imaging Evaluation: Software EL-Fit

Ref.-Nr.: 1401-4175-WT

IT / Software / Bioinformatik

This software is based on the paper "Quantitative evaluation of electroluminescence images of solar cells" by O. Breitenstein et al.1). It allows to load a number of electroluminescence (EL) images to different biases, which have to be given as ASCii tables.

Electron Microscopy: Ready to Use AI for Focus and Astigmatism Adjustment

Ref.-Nr.: 0202-6337-BC

Bildgebung und Mikroskopie

The invention relates to a new method for imaging setting optimization for electron microscopy
based on deep learning. The AI is a robust and simple to implement optimization possibility for
direct operation with various types of electron microscopes.

For a wide spectrum of applications automated precision electron microscopy is a powerful
method. Existing auto focusing routines are often based on physical models of the microscope
and are hence lacking general applicability ...

Enhancement resonator including non-spherical mirrors

Ref.-Nr.: 1202-4590-WT

Sensoren, Geräte und Komponenten

An Enhancement Cavity (EC) with at least one toroidal and/or cylindrical mirror is described. This allows for an arbitrary beam ellipticity of the eigenmode. In particular at a stability edge, where the ellipticity diverges with purely spherical optics, a round beam can be obtained.

Environmental Monitoring: Detection of Atmospheric Particulate Matter PM2.5

Ref.-Nr.: 1629-5711-WT

Sensoren, Geräte und Komponenten

The invention relates to a new and durable system, which brings the possibility of accurate size measuring and simultaneous counting of airborne particles with an aerodynamic diameter of up to 2.5 microns.

Measuring the particulate matter contamination in a gas in the range of PM2.5 is advantageous or crucial for various applications. Monitoring the concentration of the corresponding particles, for example in air, reveals information about pollution. The possibility of aerosol ...

Exergy Efficient Chlorine Separation

Ref.-Nr.: 1402-5465-LC

Prozesse und Methoden (inkl. Screening) : Chemische

Three novel processes to separate Cl2 from unconverted HCl in the anode outlet stream of a electrochemical gas-phase reactor were developed at the MPI for Dynamics of Complex Technical Systems. The novel processes lead to a higher reaction yield in gas-phase reactor and have an reduced energy demand compared to the Bayer UhDenora state-of-the-art process.

Exploitation of mineral cesium from mineral sources

Ref.-Nr.: 0042-5371-LC / SGK A477

Prozesse und Methoden (inkl. Screening)
Medizin

Prof. Klaus-Richard Pörschke and co-workers at the MPI for Coal Research developed a novel cyclic process for the quantitative extraction of cesium with 100% selectivity from any given aqueous or acidic solution, irrespective of the other components.

Extraction of nanocellulose from cellulose pulp in reactive eutectic media

Ref.-Nr.: 0401-5970-LC

Prozesse und Methoden (inkl. Screening)
Neue Materialien

A novel green chemistry process to prepare nanocellulose in efficient, safe and sustainable manner based on the use of eutectic, highly concentrated ionic media is offered.

f-Chrimson and vf-Chrimson, two ultrafast variants of the red-light activated channelrhodopsin Chrimson

Ref.-Nr.: 0601-5208-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues, and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...

Fabrication of ultrathin nano-porous membranes and semiconductor nanowires

Ref-Nr.: 0104-4458-GÖ

Bildgebung und Mikroskopie
Neue Materialien

Semiconductor nanowires are of vital importance for many applications, such as flexible electronics, photonics, sensors, and energy harvesting and storage devices. As standard fabrication procedure, vapor-liquid-solid (VLS) growth employs metal catalyst particles (such as gold) as seeds for growth of nanowires. The seeds are deposited on a solid substrate, melted by heating and then exposed to a gas atmosphere containing source materials of the semiconductor. When the metal droplets are supersaturated, ...

Fast and efficient protein purification form prokaryotic and eukaryotic hosts

Ref.-Nr.: 0109-4896-LI

Prozesse und Methoden (inkl. Screening)

Fusion Tags Comprising Ubiquitin-like Modifiers and Corresponding Proteases For Protein Purification From Selected Eukaryotic Expression Hosts

Fast Photodetector with Intrinsic Amplification: Avalanche Photodiode Array

Ref.-Nr.: 1201-5750-BC

Sensoren, Geräte und Komponenten

The invention relates to a new monolithic Avalanche Photodiode array with a novel inter pixel isolation structure. The technology allows the design of sensitive photodetectors with remarkable spatial resolution at very fast imaging capabilities for various applications.
Although Avalanche Photodiodes are a convenient tool due to their intrinsic amplification, their use in photodetectors with high pixel densities is challenging due to insufficient isolation of the pixels. Hence their use in ...

Faster Processing: Neural Network for MR Imaging Parameter Prediction

Ref.-Nr.: 0107-6054-BC

Bildgebung und Mikroskopie

The invention relates to a new method for processing magnetic resonance (MR) data based on a neural network (NN). After training, the NN quickly delivers high quality CEST images with low computational effort. Additionally, it provides uncertainty data aiding to judge the images appropriately.

Typically, sophisticated MR contrasts are calculated based on complex mathematical models, which is computationally expensive, and it requires long processing durations. Besides that, the results ...

FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies

Ref.-Nr.: 0603-4987-IKF

Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.

Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)

Ref.-Nr.: 0707-4198-BC

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) is nowadays a leading mo¬dality for diagnostic imaging with about 100 million examinations per year worldwide. However, when invented by Paul Christian Lauterbur in 1973, MRI was too slow to allow for routine medical applications. A breakthrough was achieved in 1985 by the FLASH (Fast Low Angle Shot) technique developed by Jens Frahm and his team at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Germany. With FLASH the measuring time for a cross-sectional ...

FlipDroppy household dispenser for powders and granular food

Ref.-Nr.: 0109-6297-LI

Sensoren, Geräte und Komponenten

Accurate dispensing device for intuitive, spill free use

FlipDroppy laboratory dispenser for solid particles, powders, and beads

Ref.-Nr.: 0109-6297-LI

Sensoren, Geräte und Komponenten

An accurate dispensing device for powders and irregularly shaped particles

Generation of induced pluripotent stem cells with one or two reprogramming factors

Ref.-Nr.: 1012-3916-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

The cellular identity of mature cells that are confined in a specialized genetic expression profile can be overcome by introducing just a few genes that encode for so-called reprogramming factors [1]. By means of this intervention, also known as reprogramming, the cells then become pluripotent and represent induced pluripotent stem cells (iPS cells) [1]. Nowadays, numerous new cell culture models have been established based on reprogramming protocols that yield iPS cells. Such cell culture models ...

Genome-Editing-Technologies - Cas9 double mutant with improved specificity compared to wild-type

Ref.-Nr.: 0306-5787-LI

Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien

The RNA-programmable DNA-endonuclease Cas9 is widely used for genome engineering, where a high degree of specificity is required. Though this is a mechanism well controlled by canonical base-pairing, there is evidence that Cas9 does accept mismatches under certain circumstances.
This might be seen as a threat to precision needed in genome engineering at least in environments where such high precision is ultimately needed and acceptance of mismatches needs to be avoided, e.g.: cellular gene ...

Genome-Editing-Technologies - Single compound or compound mix dramatically improve Homology-Directed-Repair (HDR)

Ref.-Nr.: 1306-5734-LI & 1306-5288-LI

Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Precise genome editing demands for homology-directed repair (HDR) by aiming to introduce a new double stranded DNA substituting for a homologous sequence but partially defect one. This substrate dependent reaction does compete with direct non-homologous end joining (NHEJ) of the double strand breaks. NHEJ is error-prone and is therefor mainly used for gene inactivation.
The rate of NHEJ is directly limiting the rate of HDR. For this reason HDR in vitro does occur on a very low level only and ...

Glue your proteins of interest together: Fast and ultra-specific enzymatic conjugation of a protein with another, synthetic compounds or even whole cells

Ref.-Nr.: 0109-5804-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Connectase is an enzyme that fuses target proteins or synthetic compounds via a small recognition tag, using a different reaction mechanism compared to known protein ligases. It prevents side reactions entirely and has absolute specificity, even in highly in complex solutions with minimum concentrations of target molecules.

GOLD gRNA - allows robust genome editing regardless of spacer sequence composition by super stable hairpin technology

Ref.-Nr.: 1306-6101-LI

Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien

A Cas nuclease such as Cas9 can introduce a DNA double strand break in a sequence target that is complementary to a 20-nt spacer sequence of its bound guide RNA (gRNA) when a protospacer adjacent motif (PAM) is present. The gRNA can be provided as duplex of spacer containing CRISPR RNA (crRNA) and trans-activating crRNA (tracrRNA). Or as a single gRNA (sgRNA) where crRNA and tracrRNA are fused by an artificial loop.
Hence a gRNA consists of the target-specific spacer and a constant part typically ...

Graphene Balls and electrochemical cells containing these materials

Ref.-Nr.: 0903-4524-LC

Neue Materialien

We offer a new simple and low cost technology to fabricate graphene-encapsulated metal or metal compound nanoparticles. The resulting hybrid nanoparticles are protected by granted substance claims in US, CN, TW and EP (DE, FR, GB, BE). Currently the patent protected graphene coated nano particles are discussed as high performance electrode materials in the lithium ion battery business (for example Samsung's "Graphene Balls").

High efficiency hydrodynamic collimation vacuum interface for atmospheric pressure ion sources

Ref.-Nr.: 1201-4433-BC

Sensoren, Geräte und Komponenten

In mass spectroscopy, many ion sources that transform the specimen to be tested into gas phase ions operate at ambient or elevated pressure. The generated ions have to be transferred into vacuum for further characterization, for instance in a mass analyzer.
The ion transfer into vacuum represents a major bottleneck. Because the pumping power increases rapidly with the size of an opening, long capillaries or small pinholes have to be used. Their transmission is commonly as low as 1%, in optimal ...

High Ferroelectricity: First Method for Production of Bulk SnTiO3

Ref.-Nr.: 1201-5559-BC

Neue Materialien

The invention relates to a new method of producing SnTiO3 for the use as a ferroelectric element. Tin titanates are known to be a class with various properties making it promising for many applications. The preparation of this material beyond thin films remained challenging.

Tin(II) oxide has a low disproportionation temperature of 350°C but the preparation of new materials is usually conducted at higher temperatures. Therefore, bulk SnTiO3 is not possible to be produced using existing ...

High-precision base editors for site-specific single nucleotide conversion

Ref.-Nr.: 0402-5782-MG

Prozesse und Methoden (inkl. Screening)

The CRISPR-Cas system is a powerful tool for site-specific genome editing. It allows for the inactivation or substitution of entire genes. However, most hereditary diseases in humans are caused by single point mutations, the correction of which requires only subtle changes to the DNA. Recently, base editors (BEs) were developed that allow the introduction of selective nucleotide substitutions. A Cas9 enzyme is fused to a nucleobase deaminase catalysing C-to-T mutations (by C-to-U deamination) ...

Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity

Ref.-Nr.: 1013-4990-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.

Hybrid Thin-Disk Amplifier

Ref.-Nr.: 1202-4510-WT

Sensoren, Geräte und Komponenten

Ultrafast amplifier systems providing high average powers (>10W) at repetition rates in the kHz regime suffer from severe accumulation of nonlinear phase inside the laser gain medium and other optical components within the amplifier. Implementation of chirped pulse amplification (CPA) constitutes a well-established method to reduce the peak intensity of the laser pulse during the amplification process [1, 2]. However, state of the art laser materials supporting high average output powers such ...

Improved Safety: Real-Time Monitoring of Thermal Power of a Nuclear Reactor

Ref.-Nr.: 0102-5836-WT

Sensoren, Geräte und Komponenten

The invention relates to a new and easy to use device for real-time monitoring of the thermal power of a nuclear reactor. It is based on the easy to access 16N decay rate in the cooling water. The robust and easy to implement method significantly improves the safety of nuclear facilities.

Nuclear reactors require high standards of safety and detailed information about changes are needed in order to control them in a safe manner. Besides detailed real-time simulations, direct ...

LABEL-FREE SEPARATION AND ANALYSIS OF MACROMOLECULES

Ref.-Nr.: 1629-4734-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten
Photonics

Laser device with kerr effect based mode-locking and operation thereof

Ref.-Nr.: 1202-4422-WT

Sensoren, Geräte und Komponenten

A laser device (100), configured for generating laser pulses, has a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12). The laser resonator (10) includes a first mode shaping section (13) which is adapted for shaping a circulating electric field coupled into the gain disk medium (11), and a second mode shaping section (14), which is adapted for shaping the circulating electric field coupled into the Kerr medium (12) independently of the electric field shaping in the first ...

Leaf metabolites as markers for mycorrhizal colonization of plant roots

Ref.-Nr.: 1602-5392-LI

Grüne Biotechnologie

Screening the level of specific blumenols in plant leaves allows simple implementation in marker assisted breeding and high-throughput analysis.

LITESEC - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

Ref.-Nr.: 0706-5707-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Arzneimittel-Darreichung
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.

Lock-in thermography evaluation software for solar cells – Local I-V 2 (replacing Local I-V)

Ref.-Nr.: 1401-4359-WT

IT / Software / Bioinformatik

The efficiency of solar cells is strongly affected by local inhomogeneities. Especially inhomogeneities of the dark-current voltage (I-V) characteristic are of interest: The local dark current-voltage characteristic is a measure for the local recombination properties of the solar cell. Lock-in thermography performed in the dark (DLIT) can be used to detect and evaluate locally increased dark current densities.

MARS – software for robust and automatic backbone assignment of protein NMR spectra

Ref.-Nr.: 0707-5990-MG

Analytik
IT / Software / Bioinformatik : (andere) Software
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

MARS is a powerful program for robust automatic backbone assignment of proteins. MARS is applicable to proteins with extreme chemical shift degeneracy such as high molecular weight proteins and partially disordered or fully intrinsically disordered proteins. MARS is successfully used in many labs world-wide as evidenced by a huge number of citations.

Method and apparatus for optical frequency comb generation using a monolithic micro-resonator

Ref.-Nr.: 1202-3760-WT

Sensoren, Geräte und Komponenten

The invention relates to a monolithic optical frequency comb generator. Furthermore, the invention relates to a method of generating an optical frequency comb.

Method and radiation source for generating pulsed coherent radiation

Ref.-Nr.: 1302-3482-WT

Sensoren, Geräte und Komponenten

The present invention relates to a method of generating pulsed coherent radiation in the UV and XUV wavelength ranges. Furthermore, the present invention relates to a radiation source for generating pulsed coherent radiation based on a high harmonic generation (HHG).

Method for cell-free protein synthesis assays or other fluorescent assays in the context of cell-free protein synthesis

Ref.-Nr.: 0204-5479-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

An improved method to perform cell-free protein synthesis (CFPS) assays or other fluorescent assays in the context of CFPS with very low reaction mix volumes. Various additional advantages allow to significantly reduce costs and time.

Method for the Calibration of a Microscope Setup

Ref.-Nr.: 1201-5661-BC

Bildgebung und Mikroskopie

Errors in super-resolution microscopy (SRM) can be identified with pairs of emitters that have fixed and precisely known relative positions. Such reference and calibration structures are exceedingly rare on the nanoscale. Here, Nitrogen-vacancy centers in diamond (NVs) offer a formidable solution. These fluorescent defects are photo-stable and due to the excellent properties of their brilliant host, do not diffuse and are resilient against temperature or chemical environment changes.

On ...

Method of producing autotrophic microorganisms with altered photorespiration and improved CO2 fixation

Ref.-Nr.: 0706-5602-IKF

Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)

Biological fixation of CO2 is an important process carried out by plants and several microorganisms, which can be harnessed for sustainable, biobased production of fuels and chemicals. Particularly, the fixation of CO2 by autotrophic microorganisms such as cyanobacteria and microalgae can be employed for converting CO2 into value-added products, such as commodity chemicals or fuels. However, the sustainable autotrophic production ...

Milestone for Plasmonics: The Plasmon Generating Transistor

Ref.-Nr.: 1201-4765-BC

Sensoren, Geräte und Komponenten

The invention relates to a new method for a plasmon emitting transistor that operates in the single quantum regime. It is a major step towards future data processing technology that is no longer based on electric currents but on the transition of light.

Developments over past decades have gradually increased the performance of computer chips, but new technologies are needed to overcome the sizing limit of classical transistors. Replacing the role of electrical currents by the use of light ...

Modular low light level sensors: a scalable approach

Ref.-Nr.: 0206-5874-BC

Sensoren, Geräte und Komponenten : Sensoren

A scalable and easy to handle method for the creation of larger (up to square meters) low light level detectors is disclosed. While the fast read-out times of a single detector is kept, the area covered by the detector ensemble (dramatically) increases. The large area is enabled by transversal connection of hybrid “base cells”. These “base cells” consist of vertically stacked tiers of (i) a detector array, (ii) a first level electronic read-out, and (iii) and a second level read-out which ...

Molecularly defined non-infectious synthetic virus-like particles to mimic biophysical features of natural pathogens

Ref.-Nr.: 0105-6291-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A synthetic virus-like particle, comprising a lipid bilayer, that can be adjusted precisely to mimic biophysical features of various natural pathogens. The lipid bilayer can also be equipped with relevant molecules such as the SARS-CoV-2 spike protein ectodomain.

Monoclonal Antibody to Detect Neutrophil Extracellular Traps via a Novel Post Translational Histone Modification

Ref.-Nr.: 0305-5699-LI

Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Antikörper

A novel tool to detect and quantify NETs using a molecular feature of NET formation that has never been proposed as a marker for NETs before

Mouse model for mitochondrial diseases

Ref.-Nr.: 1013-4827-IKF

Medizin : Tiermodelle
Forschungs-Reagenzien

A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.

Multichannel coil for UHF MRI

Ref.-Nr.: 0107-4677-BC

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Exploiting the benefits offered by magnetic resonance imaging (MRI) at ultra-high fields (≥ 7 Tesla) requires optimized radiofrequency (RF) coils. MRI at UHF operates in a regime where the RF wavelength is comparable to the dimensions of the sample size, resulting in an inhomogeneous distribution of the transmit field (B1+) and in an impaired image quality. An array of independent transmit coils arranged in multiple rows provides the degrees of freedom to influence the ...

Multifunctional RFID-based Platform for Animal Observation and Manipulation

Ref.-Nr.: 0214-5247-MG und 0214-5440-MG

IT / Software / Bioinformatik : (andere) Software
Sensoren, Geräte und Komponenten : Sensoren
Sensoren, Geräte und Komponenten : Geräte
Sensoren, Geräte und Komponenten : Komponenten

≠¡]} Julius Kramer

An efficient system to monitor and control animal behavior in wildlife as well as in laboratory settings

N-substituted pyridiniophosphines, processes for their preparation and their use

Ref.-Nr.: 0042-4938-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.

Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.

Nanographene-based dyes as high performance probes for super-resolution microscopy

Ref.-Nr.: 0903-5658-LC; 0903-5696-LC

Analytik
Bildgebung und Mikroskopie
Neue Materialien

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).

They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.

These nanographene ...

Near-Unity Efficiency: Novel Light Collecting Antenna for Quantum Technologies

Ref.-Nr.: 1629-6049-WT

Photonics

The invention relates to a new concept for a high efficiency light antenna, namely the Truncated Omnidirectional Reflector (TOR). It is well suited for obtaining directional emission and efficient fiber coupling from various types of light sources like single photon emitters.
Especially in the fast-growing field of quantum technologies efficient collectors for solid-state single photon emitters are needed. Achieving collector efficiencies of more than 95% into the fundamental Gaussian mode, ...

Neuro-epithelial stem cells (NESC) capable of forming both central nervous system (CNS) and peripheral nervous system (PNS) neurons

Ref.-Nr.: 1012-4430-LI

Prozesse und Methoden (inkl. Screening)

File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)

A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.

New KDAC assay and selection system

Ref.-Nr.: 0803-5480-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

We present an extremely sensitive, reliable and fast novel Lysine deacetylase (KDAC) assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion.

We furthermore offer a bacterial selection system that can help engineer KDACs. The selection system uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby ...

Newly identified subpopulation of NK cells with the promise to treat obesity-associated pathologies: diabetes and cancer

Ref.-Nr.: 0802-5237-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

myNK cells are a novel myeloid NK subpopulation showing a unique expression pattern with the promise to treat obesity-associated pathologies such as cancer and diabetes. They could be detected in several different tumor tissues and a selective targeting of the upregulated myeloid markers might open the door for immunotherapy as a treatment option of certain obesity-associated cancer entities, obesity and diabetes.

Noise Free Imaging: Incoherent Light Source for Microscopy

Ref.-Nr.: 1629-5817-WT

Bildgebung und Mikroskopie

The invention relates to a new light source exhibiting a high level of spatial incoherence. This enables microscopic imaging with reduced artefacts and low intensity noise. It comprises a pulsed laser whose beam properties are improved is by a multimode optical fiber.
Full field microscopic imaging is an essential technique in medicine and beyond, but the occurrence of noise strongly limits its applicability. Coherent light contributes considerably to the formation of artefacts. Hence the ...

Non-collinear spin-valve

Ref.-Nr.: 1201-5998-BC

Sensoren, Geräte und Komponenten

A classical spin valve (SV) is a device in which the electrical resistance depends on the relative position of the magnetic moments of two ferromagnetic (FM) layers: with parallel (P) and antiparallel (AP) ordering, the SV resistance is minimum and maximum, respectively. Nowadays SVs are actively used in magnetic sensors, hard disk read heads and magnetic random-access memory. Thus, the SV, analogous to a transistor in conventional electronics, is a binary (digital) device. Here we offer a new ...

Novel antiviral therapy against HIV-1 and alphaviruses: reducing frameshifting by increasing tRNALeu concentrations

Ref.-Nr.: 0707-5639-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression

Novel Biomarkers for Ageing and Metabolic Health

Ref.-Nr.: 1013-5354-IKF

Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...

Novel compounds for plant disease control

Ref.-Nr.: 0707-5356-MG

Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Grüne Biotechnologie

Plant pathogenic fungi, oomycetes and bacteria have highly diverse lifestyles, infection strategies and morphologies. Therefore, pesticides frequently target basic cellular processes, as these are well characterized and often very similar among plant pathogens. Many pesticides target enzymes that play a role in e.g. nucleic acid synthesis, respiration, cell division and other essential cellular processes. However, the molecular ...

Novel Lignin Nanocarriers for Smart Drug Delivery in Crop Protection

Ref.-Nr.: 0903-4955-LC

Grüne Biotechnologie

The Max Planck Institute for Polymer Research in collaboration with the Institute of Biotechnology and Drug Research (IBWF) developed novel lignin nanocarriers that can be used for smart pesticide delivery in plants for crop protection. The nanocarriers are characterised by a narrow size distribution and an easy manufacturing, furthermore, they can be loaded with hydrophobic pesticides. Injected to plants, the nanocarriers act as a safe store of pesticide, which is released in situ by lignin degrading ...

Novel method for analysis of complex carbohydrate structures by ion-mobility mass spectrometry (IM-MS)

Ref.-Nr.: 0401-5070-MG

Analytik

Carbohydrates form one of the major classes of biological macromolecules in living organisms, but structural analysis and the quality control of carbohydrate structures represent a major challenge due to the frequent occurrence of isomers that are difficult to distinguish using established techniques.

Changes in protein glycosylation are frequently identified in the context of diseases. For example, alterations in N-glycan profiles from blood plasma have been found to correlate with pathological ...

Novel protein expression optimization method combining machine learning with insights from mechanistic modelling of mRNA translation

Ref.-Nr.: 0401-5011-LC-WA

IT / Software / Bioinformatik : Bioinformatik

Researchers of the Max-Planck-Institute for Colloids and Interfaces and the Paul-Ehrlich-Institute (PEI) have developed a novel codon-specific elongation model (COSEM), that is based on the question how codon bias affects protein expression in combination with a deep understanding of protein synthesis.

Optimised Flow-Through-Cell for Online-Microscopy

Ref.-Nr.: 1402-5292-BC

Neue Materialien

For the evaluation of crystallisation processes, process parameters like temperature and concentration can be easily measured. However, to measure the crystal size distribution continuously is a challenging task.
Different methods relaying on back scattering or reflection of monochromatic light can be applied that yield chord-length distributions, which often deviate from the actual crystal or particle size distribution. For analysing the true crystal dimensions and, additionally, the crystal ...

Optimization of Multi-Channel Coil for Magnetic Resonance Imaging

Ref.-Nr.: 1302-4127-BC

Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) requires optimal radio-frequency (RF) coil performance that ensures the highest RF magnetic field per unit power delivered to the coil, while maintaining the highest achievable RF field homogeneity. For MRI at high magnetic field level, it is important to use a multi-channel transmit coil for producing the desired RF field. However, it is impossible to design a multi-channel coil without considerable coupling between its coil elements. The major challenge in multi-channel ...

Organotextile Catalysis

Ref.-Nr.: 0042-4764-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

An easy process for the facile and permanent immobilization of organocatalysts on nylon textiles was developed.
All of the prepared textile-immobilized organocatalysts (a Lewis basic, a Brønsted acidic, and a chiral organocatalyst) display excellent stability, activity and recyclability for various organic transformations. Very good enantioselectivity (>95:5 enantiomeric ratio) can be maintained for more than 250 cycles of asymmetric catalysis. The flexible construction of fabrics allows ...

Ozone scrubber

Ref.-Nr.: 0901-5500-LC

Analytik
Prozesse und Methoden (inkl. Screening) : Chemische

Fig. 1: shows the efficiency of a stainless steel ozone scrubber comprising a thiosulfate coated surface as described herein versus the efficiency of an identical stainless steel ozone scrubber without a thiosulfate coated surface.

Scientists in the group of Atmospheric Chemistry at the Max Planck Institute for Chemistry in Mainz have developed a novel thiosulfate based ozone scrubber to ensure accurate measurements of trace analytes. It is known from the literature that commercial potassium iodide (KI) containing ozone scrubbers can cause errors in the measurement of carbonyl compounds such as aldehydes and ketones due to byproducts formed from the oxidation of KI. Commercial ozone scrubbers based on sodium thiosulfate ...

PALES software package

Ref.-Nr.: 0707-5926/6382-MG

IT / Software / Bioinformatik : Bioinformatik

NMR spectroscopy is a unique technique for the assignment of the constitution, configuration and conformation of small molecules, natural products, proteins, nucleic acid and oligosaccharides. NMR-derived residual dipolar couplings overcome limitations associated with traditional NMR data, avoid data misinterpretation and provide novel insights into structure-activity relationships. In order to leverage the full potential of residual dipolar couplings, however, powerful dedicated software and ...

Parallel-imaging time-of-flight momentum microscope

Ref.-Nr.: 1401-4572-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten : Geräte

The state of an electron is completely defined by its momentum and spin. In processes like electron diffraction or photoemission electron ensembles are generated which have a characteristic 3D distribution of momentum and spin. To examine such events the three components of the momentum vector have to be measured. Up to now, the momentum distribution of an ensemble of charged particles was typically measured using energy-dispersive spectrometers based on sequential approaches (sequentially changing ...

Peptides and methods for carbon-carbon bond formation

Ref.-Nr.: 0706-5856-IKF

Prozesse und Methoden (inkl. Screening) : Chemische

One of biotechnology’s central goals is the synthesis of multicarbon compounds under mild and sustainable conditions from renewable resources. This requires biocatalysts and methods that enable selective C-C bond formation (carboligation) between two carbon units.

Moreover, optically active compounds can be used for optically resolving agents of medical or agriculture supplies such as 2-amino-1-butanol which is a starting material of the antituberculous drug ethambutol, diltiazem hydrochloride ...

PLAYFUL Reactive Programming for Orchestrating Robotic Behavior

Ref.-Nr.: 0104-5603-BC

IT / Software / Bioinformatik

Playful is a scripting language for orchestration of Python modules. Playful allows developers to both organize the logic of activation in reactive behaviour tree and setup sensory-motor couplings, making it especially useful for robotics

PONy Dyes – Fluorescent Dyes with Phosphorus Substituents

Ref.-Nr.: 0707-5297-BC

Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. In particular, the sensitive and stable imaging of cellular components depends on the favourable combination of chemical, biological and physical factors. The availability and proper choice of fluorescent dyes is a key factor to success in the entire labelling and imaging procedure. Due to their superior brightness and photostability, synthetic dyes represent an attractive alternative ...

Precision Microscopy: Detector for Changes in Direction of a Light Beam

Ref.-Nr.: 0105-5623-BC

Bildgebung und Mikroskopie

The invention relates to a new method for light beam angle detection that is based on interferometry. High precision and sensitivity for slight changes of the beam direction can be achieved with this method.
For high precision light microscopy, the light beam must be aligned accurately, and the beam direction stability must be ensured in order to maintain a sufficient imaging resolution over longer periods of time. In standard microscopy environments even small temperature changes can result ...

Predicting concentrations, reactions rates and rate constants in biochemical networks

Ref.-Nr.: 0402-5469-MG

Analytik
IT / Software / Bioinformatik : Bioinformatik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.

Process for producing a mesoporous carbide

Ref.-Nr.: 0041-4518-WT

Neue Materialien

Mesoporous materials present a large surface-to-volume ratio providing sites for catalysis, molecular separation, adsorption or chemical sensing. Some of the classical mesoporous materials employed include silica, alumina, zirconia, zeolites, and other diverse oxides such Ti or Co, and they are synthetized by routes as self-assembly, sol-gel, spray drying and some variations of these methods known in the state of the art. Additionally, some elements of the platinum group such as Pd, Ru, and their ...

Protein Cristallography (XDS)

Ref.-Nr.: 0105-1318-WT

IT / Software / Bioinformatik

X-ray Detector Software for processing single-crystal monochromatic diffraction data recorded by the rotation method.

Reducing phase singularities in speckle interferometry

Ref.-Nr.: 1629-5142-WT

Sensoren, Geräte und Komponenten : Geräte

Speckle interferometry is an established metrology technique for the characterization of rough objects. Deformations of rough objects under a load can be determined, as well as – with the help of an additional second wavelength – the surface shape of the object under test. As an illustration, Figure 1 (left) shows the so called raw phase as a result of a deformation measurement on a metal plate. The shape and the density of the fringes indicate the response of the metal plate to the load.
Owing ...

Scalable coupling part machined from one workpiece

Ref.-Nr.: 0704-5610-BC

Sensoren, Geräte und Komponenten : Komponenten

The invention describes an easy and cheap to produce, compact coupling part, manufactured out of one workpiece. This part, scalable for shaft diameters as low as 1 mm upwards, enables a quick and secure, backlash-free one- or two-sided engagement of shafts without the need for working space or additional tools (like a screwdriver). If requested, torque limited coupling (in one or both rotation directions) is possible. The production methods comprise a variety of materials and manufacturing processes. ...

Sensor for the Carrier-envelope Phase of Short Laser Pulses: A Measuring Device and a Laser Control Device

Ref.-Nr.: 1202-4253-WT

Sensoren, Geräte und Komponenten

We present a sensor for the carrier-envelope phase of a few-cycle femtosecond laser. The sensor uses the electron current emitted from a nanoscale metal tip onto which we focus high-repetition-rate laser pulses.

Possible applications of this sensor are in the field of the technique of controlling and using pulse lasers, in particular used for measuring or high-power irradiation purposes.

The size of such a simple stand-alone sensor device for the carrier-envelope phase could be in ...

SIMNRA 7 software

Ref.-Nr.: 1801-4849-WT

IT / Software / Bioinformatik

SIMNRA is a Microsoft Windows program for the simulation of energy spectra for ion beam analysis with incident ions from about 100 keV to many MeV. SIMNRA can be used for the simulation of Rutherford backscattering (RBS), elastic backscattering with non-Rutherford cross-sections (EBS), nuclear reaction analysis (NRA), elastic recoil detection analysis (ERDA), and medium energy ion scattering (MEIS). Almost 3000 different non-Rutherford and nuclear reactions cross-sections for incident protons, ...

Simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples

Ref.-Nr.: 0105-5434-IKF

Analytik

A simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples, with various applications such as enzymatic assays, clinicals tests, and as point of care tests in the field of ageing.

Simultaneous multi-color fluorescence microscopy with improved spatio-temporal resolution and image contrast

Ref.-Nr.: 0707-5644-BC

Bildgebung und Mikroskopie

Fluorescence microscopy is one of the key techniques in the life and materials sciences, with applications ranging from routine diagnostics to state-of-the-art research investigations. Key to this success has been its intrinsic advantages combined with continuous improvement in its fundamental features such as resolution, speed, and sensitivity.


Two key challenges are fast single-fluorophore imaging of multi-color samples. This need arises in a broad range of settings such as very high-resolution ...

Single Photon Detection: Advanced DePFET with High Amplification

Ref.-Nr.: 1201-5766-BC

Sensoren, Geräte und Komponenten

The invention relates to a new and improved concept for Depleted p-channel Field Effect Transistors (DePFET) detectors that provides a significantly higher intrinsic amplification. By the extension of the transistor layout, former limitations were overcome.
DePFETs are insufficient for many applications in terms of the achievable intrinsic amplification. This is since shorter transistor channels needed for high amplification would increase the detector noise caused by impact ionization events.
Additional ...

SNOM: New Sensitive Detection Method for Small Periodic Signals

Ref.-Nr.: 0302-6225-BC

Sensoren, Geräte und Komponenten

The invention relates to a new detection method for small periodic signals in Scanning Near Field Optical Microscopy (s-SNOM). Solving the problem of the rapid sampling rates necessary for lock-in amplification, the method is a powerful new readout system for various other applications as well.

Lock-in detection is a widespread technique, which enables the detection of very small periodic signals. However, it imposes constraints between the lock-in modulation frequency and the sampling ...

Soft Capsule Endoscope - "B-MASCE"

Ref.-Nr.: 0104-5410-BC

Sensoren, Geräte und Komponenten

Im Zuge der stetigen Weiterentwicklung und Nachfrage auf dem Gebiet der minimal invasiven Chirugie wurde am Max-Planck-Institut für intelligente Systeme in Stuttgart im Team von Herrn Prof Sitti für patientenfreundliche Magen-Darm-Untersuchungen ein kabelloses kapselförmiges Endoskop in Pillengröße, das sogenannte "B-MASCE" entwickelt. Die aus einem Elastomer bestehende Kapsel dient hierbei sowohl als Gehäuse als auch als Federelement für die Nadel. Über in der Kapsel eingebaute Magnete ...

Stable, site-specific conjugation of His-tagged proteins via cobalt (III) carbonate reagents

Ref.-Nr.: 0105-5774-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

This invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier.

Substituted Imidazolium Sulfuranes and their use as novel Electrophilic Group-Transfer Reagents

Ref.-Nr.: 0042-5063-LC

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

The ability of hypervalent iodine compounds to act as electrophilic group-transfer reagents has been extensively exploited during the last several years in a variety of synthetically useful transformations
like cyanations and alkynylations. Now it was found, that novel imidazolium sulfuranes, which are isolobal to I(III) species and also depict the key threecenter four-electron bond motive, can be used as an alternative platform for the development of new electrophilic group-transfer reagents.

Imidazolium ...

SUMOvera: A Truly Orthogonal Cleavage Module

Ref.-Nr.: 0402-5439-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

Superamphiphobic membranes for gas exchange and scrubbing

Ref.-Nr.: 0903-4616-LC

Neue Materialien

Novel gas exchange membranes based on superamphiphobic coatings applied on metal meshes were created and tested in different applications, like gas scrubbing and blood oxygenation.
By using the novel membrans drawbacks of traditional membranes - like insufficient wetting, plugging and depositions chemical incompatibility and temperature instability - can be avoided.

Sustainable High-Performance Energy Storage: The Solar Battery

Ref.-Nr.: 0104-5740-BC

Neue Materialien

The invention relates to a new solar battery half-cell that can be recharged by natural resources like sunlight. Remarkable sustainability is provided by the possibility to use sunlight as a source of primary energy and by solving the problem of low capacity of state-of-the-art battery technologies.

Sustainable solutions for efficient storage of electrical energy are of great importance for the global energy transition and other applications. Typical batteries, however, are often charged ...

Synchrotron Serial Snapshot Crystallography of Biological Nanocrystals carried in Microscopic, Ultra-Slow, High Viscosity Free-Streams

Ref.-Nr.: 0105-4794-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Physikalische

An apparatus and method allowing high throughput collection of X-ray diffraction data at room temperature.

Tet-inducible “gePSI” protein reversibly regulates eukaryotic ribosomal protein synthesis in a cell-type specific manner allowing to impose and release protein synthesis inhibition in a select subset of cells in mixtures

Ref.-Nr.: 0602-5504-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

Proteins are the main functional units within cells. Their regulated synthesis and degradation are crucial for controlling biological processes. In all cells, protein synthesis is used to respond to extra- and/or intracellular cues to remodel cellular function. Previous studies probing the role of protein synthesis have used chemical inhibitors, often common antibiotics, which are effective but lack functional and cell-type specificity when applied to a mixture of cells.

The Camera Offset Space: Real-time Potentially Visible Set Computations for Streaming Rendering

Ref.-Nr.: 1200-5472-BC

IT / Software / Bioinformatik

The presented technology offers an enhanced streaming rendering pipeline that enables the display of high fidelity, high framerate and high solution for noval views in real time on thin lightweight HMDs suitable especially for VR experiences.

How does it work?

The key idea of this technology is based on a novel algorithm for Potentially Visible Set (PVS) creation: the camera offset space (COS), which for a given point on the image plane provides information under which camera ...

Touchless Positioning Interface: The Precise Nanosheet Moisture Sensor

Ref.-Nr.: 1201-4882-BC

Sensoren, Geräte und Komponenten : Sensoren

The invention relates to a new precise sensing device for gas and vapor that is based on a 2D nanosheet material. A remarkably high sensitivity allows for the application in smart touchless interfaces to operate future digital devices.

Sensors for environmental changes are one of the most promising approaches for touchless interface devices but state-of-the-art technologies are not satisfactory. They typically exhibit too long response times.

With its capability to resolve sub-centimeter ...

Ultracompact medical ventilation system

Ref.-Nr.: 0901-6012-WT

Medizin
Sensoren, Geräte und Komponenten

Comparison of the ventilation unit (left hand side) with a tennis ball.

The invention relates to a new, ultracompact non-invasive medical ventilation system. The BIPAP (Biphasic Positive Airway Pressure) ventilation unit, of size and weight of a tennis ball, is easy to handle and allows low-budget mass production. It can be powered by a rechargeable battery-pack – a great advantage in case of mobile use or damaged/unstable infrastructure leading to frequent blackouts. These benefits, ...

Ultrafast Charging-Discharging of Nano-sized Na₃V₂(PO₄)₃ Embedded in Porous Carbon Matrix for Sodium Ion Batteries

Ref.-Nr.: 1201-4746-LC

Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

We offer the new composite nanomaterial for sodium ion battery cathodes. These carbon-coated nanosized Na3V2(PO4)3 particles embedded in a highly effective mixed conducting porous carbon matrix can be easily prepared by means of facile soft-chemistry based preparation method with a post heat treatment procedure. The resulting cathodes can be charged and discharged in 6 s with high current density of 22 A/g, deliver the specific capacity of 44 mAh/g and ...

Uniform Deposition of Large-Area Multicomponent Coatings using Laser Irradiation Scanning of Predesigned Targets

Ref.-Nr.: 1201-4172-BC

Sensoren, Geräte und Komponenten

Pulsed laser deposition (PLD) facilitates efficient production of thin films using a laser ablation technique. Targets are selected according to the coating desired. Multiple targets are either moved mechanically to the incidence area, or they are fixed so that the laser beam is alternatively focused on each of them. Multiple targets are, however, known to cause discontinuities, whereas single multicomponent target usually doesn’t ensure compositional homogeneity. The technology presented here ...

Unique multifunctional oligonucleotide enabling ultrafast RNA-protein interactions in cells and other uses thereof

Ref.-Nr.: 0214-5029-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Unique multifunctional oligonucleotide for the ultrafast transcriptome-wide identification of RNA-binding protein (RBP) targets.

Water content sensor for biological soil crusts

Ref.-No.: 0901-4720-WT

Sensoren, Geräte und Komponenten

In arid and semiarid regions biological soil crusts (BSC) cover about 1/3 of the soil surface. As far as it is known, these BSC (consisting of cyanobacteria, algae, fungi, bryophytes, and other bacteria living in contact with soil particles) are crucial for the global terrestrial carbon and nitrogen cycle. The water status plays a major role, since their water content directly controls the activity of these poikilohydric organisms.

Xenorhodopsin - a new inward-directed proton pump for an alternative optogentic approach

Ref.-Nr.: 0601-5295-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues, and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...