Technologieangebote
(Differential) Refractive Index Measurement with low Uncertainties and Dimensions using an Asymmetric Nanofluidic Grating Detector
Ref.-Nr.: 0707-5502-BC
Sensoren, Geräte und Komponenten

The invention relates to a new method for measuring the refractive index n of a substance with low uncertainties. The latter is in particular the case when the deviation of the refractive indices Δn, as compared to another substance, is only small (Δn < 0.02). Thereby, sensitive and contactless information on molecule concentration or process conditions for a wide range of applications can be obtained. The low uncertainties are enabled through the development of an asymmetric nanofluidic ...
A genetically conserved and transferable defense mechanism protects plants from herbivores
Ref.-Nr.: 1602-6322-LI
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Grüne Biotechnologie

Our scientists have identified a conserved defense mechanism covering a new metabolite in tobacco that protects against leafhoppers. They have discovered how to reconstitute it in vitro and engineer the compound in crop plants, demonstrating that it confers resistance to herbivores.
A graphene diode with bias-induced barrier modulation
Ref.-Nr.: 1201-5155-BC
Sensoren, Geräte und Komponenten

Metal-insulator-metal (MIM) diodes are very promising for application as rectennas for solar energy harvesting, photo-detectors and high frequency mixers. Good MIM diode performance requires a high asymmetry, a strong nonlinearity, a large responsively, as well as a low resistance or a high on-current. These figures of merit are mainly determined by the work function difference of the electrodes, and the barrier height between the insulator and the electrode materials. In the design of MIM diodes, ...
Weiterlesen … A graphene diode with bias-induced barrier modulation
A high-throughput compatible workflow for generation and analysis of homogenous human neural microtissues
Ref.-Nr.: 1012-5677-LI
Prozesse und Methoden (inkl. Screening)
File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)
A robust method for producing and analyzing highly homogenous human neural organoids.
A method and device for reversibly attaching a phase changing metal to an object
Ref.-Nr.: 0104-5132-BC
Sensoren, Geräte und Komponenten

Reversible adhesion can be used to transfer or to manipulate objects. Especially if the objects are small and/or fragile their manipulation become very challenging. Intermolecular forces such as Van-der-Waals can be used to achieve a strong adhesion between the objects. Moreover, surface functionalization and the creation of nano- and microstructures can be used to improve these adhesion properties. Unfortunately, the adhesion becomes insufficient if the surfaces are wet or rough. Another problems ...
Weiterlesen … A method and device for reversibly attaching a phase changing metal to an object
A method for the production of plants with altered photorespiration and improved CO2 fixation
Ref.-Nr.: 0706-5666-IKF
Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Grüne Biotechnologie
Recently, many efforts have been made to improve growth and yield of crop plants. CO2 fixation in plants is primarily catalyzed by the enzyme ribulose-1,5-bisphosphate carboxylase (Rubisco). The inherent inefficiency of Rubisco necessitates an additional metabolic process termed photorespiration, which results in the loss of carbon and energy. In fact, it has been estimated that plants lose approximately 25% of the fixed carbon due to photorespiration. Despite several attempts to improve ...
A MONTE-CARLO CODE FOR CALCULATING COLLISION PHENOMENA IN RANDOMIZED TARGETS
Ref.-Nr.: 1801-6323-WT
IT / Software / Bioinformatik

The invention relates to a Monte-Carlo program implemented in Fortran 90. It treats the bombardment of incident ions on different target structures such as mono-atomic targets, layer structures or composition target structures. The two general cases considered in the code are the static case, where the target composition is fixed during the simulation, and the dynamic case, where modifications of the target caused by the ion bombardment are taken into account. Prospectively, further developments ...
Weiterlesen … A MONTE-CARLO CODE FOR CALCULATING COLLISION PHENOMENA IN RANDOMIZED TARGETS
A novel biomarker for a reliable diagnosis of colorectal cancer based on differentially methylated genomic regions
Ref.-Nr.: 0301-4550-LI
Medizin : Diagnostika
With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...
A novel class of herbal compounds saiginols with strong UV-B absorbing properties
Ref.-Nr.: 0402-4816-MG
Grüne Biotechnologie
UV-B radiation is a major damaging agent causing damage to plants, tissues and human or animal skin upon exposure. To persist strong UV-B radiation plants produce additional antioxidant sunscreen pigments that belong to the chemical compound family of phenylpropanoids. Since many conventional compounds with sunscreen protection potential do not enter the market due to toxic side effects or they bear the risk to become environmental pollutants when accumulating in natural resources, application ...
Weiterlesen … A novel class of herbal compounds saiginols with strong UV-B absorbing properties
A novel inhibitor targeting matrix accumulation in cancer
Ref.-Nr.: 0105-5855_1-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...
Weiterlesen … A novel inhibitor targeting matrix accumulation in cancer
A novel inhibitor targeting matrix accumulation in fibrosis
Ref.-Nr.: 0105-5855_2-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Fibrosis is the excessive accumulation of extracellular matrix that leads to destruction of the tissue architecture and consequently organ failure. In the developed world, an estimated 45 % of all deaths resulted from severe fibrotic diseases. A wide range of chronic diseases are able to induce fibrosis such as hepatitis, pulmonary disease, scleroderma and cancer. Current therapies for fibrosis are limited and of low efficacy. Further research on fibrosis is required to understand disease progression ...
Weiterlesen … A novel inhibitor targeting matrix accumulation in fibrosis
A novel type of influenza A virus-derived Defective interfering Particle for antiviral therapy
Ref.-Nr.: 1402-5459-BC
Forschungs-Reagenzien : Antikörper

Human influenza A virus (IAV) is responsible for seasonal disease in people and can cause worldwide pandemics. The main lines of defense against IAV are vaccines and antiviral drugs.
Influenza vaccines, including killed and live vaccines, recombinant virus-like particles and viral particles, have been available commercially for many years. Typically, the composition of influenza vaccines is based on the major influenza virus strains causing infection in the previous season. Accordingly, ...
A process for recycling of noble metals
Ref.-Nr.: 0041-5034-WT
Prozesse und Methoden (inkl. Screening)

Noble metals are used in various fields of application such as catalysis, jewelry, high technology electronic equipment, equipment for glass industry and many others. As noble metals are rare and hard to extract from the ores or exhausted compounds, many efforts have been undertaken to establish an efficient recycling process. Due to their corrosion resistant properties, noble metals recycling by means of dissolution is limited to the usage of very reactive and harmful chemicals such as Aqua Regia. ...
A system-wide approach for the identification of druggable proteins in a complex mixture
Ref.-Nr.: 0402-5163-MG
Analytik
In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...
A tunable cohesive granular material
Ref.-Nr.: 0705-5158-BC
Neue Materialien

For sieving and separation purposes porous materials with adjustable sizes and shapes of the pores as well as tunable mechanical properties are required. The existing materials such as sintered materials, open-cell foams or cemented aggregates can be made porous but they are either fragile or can collapse for large deformation. Therefore, chemically inert and damage resistant porous materials with adjustable permeability as well as mechanical and geometrical properties that can sustain large deformation ...
ABSOLUTE OPTICAL CHIRAL ANALYSIS
Ref.-Nr.: 0901-6167-LC
Analytik

The offered invention relates to a device adapted to measure in real time the absolute chirality of a material. The device uses cavity-enhanced polarimetry (CCP), which allows for accurate enantiomeric excess determination of chiral compounds within mixtures at trace levels, without the need for calibration, even in the gas phase. Furthermore, by measuring the central frequency of any cavity mode, the device can directly measure the average refractive index of the intracavity medium.
Accurate contactless measurement of surface and micro sample temperatures
Ref.-Nr.: 0041-5601-WT
Sensoren, Geräte und Komponenten

The study of mechanical properties of materials at high temperatures at the microstructural length scale requires dedicated testing setups. An accurate measurement of the sample temperature is vital for reliable testing. Most of the successful current testing platforms record the temperatures of the sample and tip near the heating sources but not at the respective surface. As a consequence, due to spatial and temporal thermal gradients a reliable surface temperature cannot be measured today. Even ...
Weiterlesen … Accurate contactless measurement of surface and micro sample temperatures
Advanced collector sweeping with homogenous power deposition of the electron beam in high-power rf vacuum-tubes
Ref.-Nr.: 1801-3749-WT
Sensoren, Geräte und Komponenten
This invention includes two alternative advanced methods to achieve a homogenous collector power distribution, which improves the collector capability of high power vacuum-tubes by a factor of two as compared to conventional methods. Furthermore the applied method has a high flexibility to vary the power distribution over a wide range of profiles and match the deposition profiles to different designs of collectors in existing or future electron tubes.
Advanced magnetic zipper for industrial and consumer applications
Ref.-Nr.: 0705-4974-BC
Sensoren, Geräte und Komponenten

Conventional mechanical zippers find manifold applications for luggage, clothing or even industrial applications. However, their design features significant disadvantages. In particular, they require the use of both hands by the user to align the ends of the garment and lock the insertion pin into the slider. This mechanism can be prone to jamming and failure and more generally requires the user to free his or her hands. The user must further use one or both hands to move the slider along the ...
Weiterlesen … Advanced magnetic zipper for industrial and consumer applications
Advanced vorticity measurements on complex flows
Ref.-Nr.: 0705-4770-BC
Sensoren, Geräte und Komponenten

The dynamics of complex flows and turbulences are dominated by vortices of many different scales. In general, the vortex describes the group motion of fluid elements in a circular fashion, whereas the vorticity quantizes this spinning moment of a fluid element confined to a small neighborhood.
For diagnosis of flows, conventional techniques track the movements of small particles added into the flow (e.g., Lagrangian particle tracking, LPT, and particle image velocimetry, PIV). However, ...
Weiterlesen … Advanced vorticity measurements on complex flows
Air-stable binary Ni(0)–olefin (pre)catalyst
Ref.-Nr.: 0042-5881-LC
Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

A family of 16-electron binary Ni(0)-stilbene complexes Ni(Rstb)3 as a new class of air-stable Ni(0) (pre)catalysts was developed.
Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Ref.-Nr.: 0305-3252-LI
Medizin : Therapeutika

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...
Weiterlesen … Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Anti-breaking Superhydrophobic and Photocatalytic Active Films used as Blood Repellent Dressing
Ref.-Nr.: 0903-5907-LC
Medizin
Neue Materialien

Highly elastic, photocatalytic active, and superhydrophobic films were prepared by self-assembly of TiO2 nanoparticles driven by crosslinking reactions of PDMS. The photocatalytic activity of the film provides self-cleaning and antibacterial properties when exposed to UV-A light. Substrates of different materials such as glass, PU, and polyester textiles can be easily modified with the film. The corresponding PDMS/TiO2 film based wound dressings can effectively block leakage ...
Anti-mouse and anti-rabbit IgG secondary VHH single domain antibodies optimized for all immuno-labeling applications
Ref.-Nr.: 0707-5419-LI
Neue Materialien
Anti-IgG secondary antibodies are major tools for the detection or immobilization of primary antibodies in approaches such as western blotting, ELISA, Co-IP and immunofluorescence. Polyclonal anti-IgG secondary antibodies are produced in animals, such as mouse, rabbit, rat, and goat and are directed against the IgG classes of these animals. Thus, the generation of such secondary antibodies requires the keeping and use of a large number of animals, which is not only costly but also a major ethical ...
Apparatus and method for creating a holographic ultrasound field in an object
Ref.-Nr.: 0104-5066-BC
Sensoren, Geräte und Komponenten

Ultrasound is being used in many fields ranging from medical imaging and therapy to non-destructive testing, contact-free particle handling or spatially selective heating in industrial settings. Often, those applications require shaping (including focusing) of an ultrasonic field. Compared to existing transducers with fixed lenses or phased array transducers (PATs) the present invention allows much more sophisticated sound fields to be generated using much simpler and cheaper technology.
Weiterlesen … Apparatus and method for creating a holographic ultrasound field in an object
Apparatus for Generating Random Numbers using an Optical Parametric Oscillator
Ref.-Nr.: 1201-5494-BC
Sensoren, Geräte und Komponenten
Photonics
The invention relates to an apparatus for generating random numbers, using an optical parametric oscillator.
The generation of random numbers is important in information science as well as in modelling and simulation. In cryptography, for instance, random numbers are needed for encryption algorithms. Preferably, the generated numbers are true (i.e. non-predictable) and have an equal distribution.
The apparatus according to the invention is based on the bi-stable outcome of an optical ...
Weiterlesen … Apparatus for Generating Random Numbers using an Optical Parametric Oscillator
Application of novel channelrhodopsins: molecular engineering, site-specific opsin targeting, discovery of new variants and the advancement in optogenetic devise development
Ref.-Nr.: 0601-4259-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...
Automated real time determination of crystal size and 3D shape distribution to quantify and predict the properties and dynamics of the crystallization processes
Ref.-Nr.: 1402-5690-LC
Analytik
Prozesse und Methoden (inkl. Screening)

To monitor crystallization processes a special camera setup to measure the crystal size and 3D shape distribution was developed.
The setup consists of two high-speed cameras that are positioned orthogonally to one another such that a precise overlap of both fields of view can be achieved. The setup further contains a specially designed flow-through cell that allows to observe the crystal suspension from both camera directions and given the opportunity to temperate the solution within the cell. ...
Bioinspired Liquid-Superrepellent Fibrillar Dry Adhesives
Ref.-Nr.: 0104-5929-GÖ
Neue Materialien

Since 2000 bioinspired fibrillar dry adhesives have been studied intensively culminating in commercial products already available on the market. Currently known fibrillar adhesives are fully wetted by oils, leading to significantly decreased adhesion and friction performance. Therefore, a high demand exists for reversible dry fibrillar adhesives that can repel oil-like liquids and adhere strongly to surfaces wetted by them.
To meet the aforementioned challenges, an extraordinary fibrillar ...
Weiterlesen … Bioinspired Liquid-Superrepellent Fibrillar Dry Adhesives
BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control
Ref.-Nr.: 1200-3727 GÖ
Analytik

BiQ Analyzer is a software tool for easy visualization and quality control of DNA methylation data. With more than a thousand users worldwide, BiQ Analyzer has become a standard tool for processing DNA methylation data from bisulfite sequencing. BiQ Analyzer has been selected by ABI to be part of the Applied Biosystems Software Community Program.
Weiterlesen … BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control
BLE-based micro-transmitter and monitoring app
Ref.-Nr.: 0707-5558-MG
Sensoren, Geräte und Komponenten : Geräte
A lightweighted, long-life, long-range and low-cost Bluetooth Low Energy (BLE)-based tracking system with monitoring app.
Weiterlesen … BLE-based micro-transmitter and monitoring app
Borylated Pyrenes and Terrylenes as blue and green emitters
Ref.-Nr.: 0903-5692-LC
Neue Materialien

Prof. Klaus Müllen an co-workers at the Max-Planck-Institute for Polymer Research developed a straightforward C-H borylation at the 2- and 2,7-positions of pyrene derivatives. The small neutral organic molecules show sharp fluorescence emission peeks between 400-550 nm and high photoluminiscense quantum yields.
Weiterlesen … Borylated Pyrenes and Terrylenes as blue and green emitters
Bottom-up assembly of synthetic extracellular vesicles for biomedical applications
Ref.-Nr.: 0105-5888-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Prozesse und Methoden (inkl. Screening) : Produktion
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Natural extracellular vesicles (EVs) are lipid vesicles that carry a plethora of biologically active molecules including soluble and membrane proteins, nucleic acids and metabolites. They have recently been recognized as a promising cell-free alternative to cell transplantation or as a novel therapeutic tool in various diseases. Many in vitro and in vivo studies have shown beneficial effects of EVs from different cell types in diseases ranging from cardiovascular conditions to ...
Weiterlesen … Bottom-up assembly of synthetic extracellular vesicles for biomedical applications
Carbon-neutral and carbon-positive photorespiration bypass routes supporting higher photosynthetic rate and yield
Ref.-Nr. 0402-5003-MG
Grüne Biotechnologie
Carbon fixation is arguably the most important biochemical processes on earth, supporting our biosphere by transforming inorganic carbon into organic matter and literally feeding all life forms. The reductive pentose phosphate cycle (rPP, also known as the Calvin–Benson–Bassham Cycle) is responsible for ≥95% of the carbon fixed in the biosphere. Although under a strong selective pressure for eons, this process displays major inefficiencies, some are due to the low catalytic rate and the ...
Cell-Penetrating Fluorescent Dyes with Secondary Alcohol Functionalities
Ref.-Nr.: 0707-5236-BC
Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. The availability and the proper choice of the dye is a key factor to success of the entire labelling and imaging procedure. Due to superior brightness and photostability, synthetic dyes often represent an attractive alternative to fluorescent proteins.
Among the multitude of fluorophores reported so far, only rhodamines, carbopyronines, and silicon-rhodamines bearing a carboxyl ...
Weiterlesen … Cell-Penetrating Fluorescent Dyes with Secondary Alcohol Functionalities
CellNetAnalyzer: A Software Package for Analyzing Structure and Function of Cellular Networks
Ref.-Nr. 1402-3895-LC
IT / Software / Bioinformatik

CellNetAnalyzer (CNA) is a MATLAB toolbox providing various computational methods for analyzing structure and function of metabolic, signaling, and regulatory networks. For metabolic networks, CNA supports a variety of stoichiometric and constraint-based modeling techniques, including flux balance analysis (FBA), metabolic flux analysis, elementary-modes analysis, or computational strain design (e.g., minimal cut set analysis). Signal transduction and (gene) regulatory networks can be ...
Chlamydomonas algae strains for molecular farming
Ref.-Nr.: 0402-3923-MG
Grüne Biotechnologie
The unicellular green alga Chlamydomonas reinhardtii is both an invaluable model organism for plant biology and an attractive biotechnological production system for biofuels and biopharmaceuticals. Despite the availability of efficient methods for introduction of foreign genes into the nuclear genome of the alga, transgene expression levels are usually very poor. This is a serious limitation that has severely hampered both post-genomics research in Chlamydomonas and use of the ...
Weiterlesen … Chlamydomonas algae strains for molecular farming
Closure Device for Evaporator Cell of a Coating System
Ref.-Nr.: 1201-5136-BC
Sensoren, Geräte und Komponenten

Evaporation cells for thin film deposition often operate under ultrahigh vacuum or special gas atmosphere, requiring long growth campaigns and short maintenance openings to preserve the best possible vacuum environment. The deposition leads to coating of the inner chamber walls, the removal of which is difficult and very time consuming. Growth control and interruptions during material deposition may require frequent operation of the closure device or shutter. The commonly used shutter (Fig. 1) ...
Weiterlesen … Closure Device for Evaporator Cell of a Coating System
Compact high-voltage vacuum feedthrough
Ref.-Nr.: 0302-4988-WT
Sensoren, Geräte und Komponenten

Applying high voltages in vacuum applications requires feedthroughs, which electrically insulate the conductor from the vacuum chamber whilst being vacuum-tight. In high- and ultrahigh vacuum environments, the materials used need to be low in outgassing rates. The current technology for feedthroughs withstanding tens to hundreds of kilovolts relies on vacuum-tight ceramic to metal connections, which are heavy, fragile and prone to contamination. Commercially available feedthroughs are stand-alone ...
Compounds modulating frameshifting efficiency for antiviral therapy against HIV-1, SARS-CoV-2 and alphaviruses
Ref.-Nr.: 0707-5639-MG
Medizin : Therapeutika
Medizin : Vakzine
Many viruses use programmed ribosome frameshifting (FS) to increase genome-coding capacity and to regulate the stoichiometric ratio between viral proteins. Among them are human-pathogenic viruses HIV-1, SARS-CoV-2 and alphaviruses such as Semliki Forest virus (SFV). Synthesis of two major HIV-1 genes, gag and pol, requires –1FS. The ratio between Gag and Gag-Pol is crucial for virus propagation and its dysregulation is detrimental for replication, particle formation and infectivity of HIV-1. ...
Core-shell catalyst design for improved heat management with highly exothermic reactions
Ref.-Nr.: 1402-5768-LC
Prozesse und Methoden (inkl. Screening)
Neue Materialien

Prof. Kai Sundmacher and co-workers at the MPI for Dynamics of Complex Technical Systems developed a novel core-shell catalyst design with a highly active catalyst core surrounded by an inert, low-permeability shell. The new catalyst design leads to an intrinsic heat management that avoids hotspots in strongly exothermic reactions. This allows faster reactor start-up and shut-down and makes the catalysts suitable for rapid load changes in discontinuous processes.
Cryo-Light Microscope and Immersion Medium for Cryo-Light Microscopy
Ref.-Nr.: 0707-5496-BC
Bildgebung und Mikroskopie

Cryogenic fluorescent light microscopy of flash-frozen cells presents significant advantages and provides an important complement to electron cryo-microscopy. In particular, bleaching decreases drastically at low temperature while the fluorescence yield of many fluorophores increases and the spectral bands narrow. The application of modern super-resolution methods such as STED, PALM, STORM, or SIM at cryogenic temperature holds the prospect of imaging fluorescent proteins with high precision in ...
Weiterlesen … Cryo-Light Microscope and Immersion Medium for Cryo-Light Microscopy
Cyclopropenylylidene-Stabilized Phosphenium Cations and their Applications in Homogeneous Catalysis
Ref.-Nr.: 0042-5177-LC-WA
Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien
We offer novel phosphenium ligands and corresponding metal complexes (both air stable) that are claimed as substances by granted EP and US patents. The ligands can be prepared in multigram scale by simple direct condensation. The corresponding gold complexes are suitable as homogeneous catalysts in organic synthesis (such as cycloisomerization) that can be easily precipitated and recycled due to their salt properties.
Decontamination of radioactive caesium in humans
Ref.-Nr.: 0042-5371-LC / SGK A477
Prozesse und Methoden (inkl. Screening)
Medizin

Prof. Klaus-Richard Pörschke and co-workers from the MPI for Coal Research developed a highly hydrophobic perfluoroaryl borate (FAB) ligand for trapping the radioative 134/137 Cs isotopes with 100% specificity. The novel approach could improve the decontamination of humans compared to the administration of so called insouble Prussian blue currently in use.
Weiterlesen … Decontamination of radioactive caesium in humans
DECONV-Software
Ref.-Nr.: 1401-4358-WT
IT / Software / Bioinformatik
Das Verfahren der Lock-in-Thermographie (LIT) gestattet es, 2-dimensionale Bilder der Verteilung der in einer Probe dissipierten Leistung zu erzeugen. Allerdings sind diese Lock-in Thermogramme noch durch die unvermeidliche laterale Wärmediffusion in der Probe "verbreitert" (blurred). Das "DECONV"-Programm gestattet es, diese thermische Verbreiterung durch die Anwendung eines örtlichen Entfaltungs-Verfahrens wieder rückgängig zu machen und dadurch die effektive Ortsauflösung der Lock-in-Thermographie ...
Digital scanner
Ref.-Nr.: 0105-5505-BC
Bildgebung und Mikroskopie

Light microscopy enables fascinating insights into the microcosm of life. It is one of the key techniques in life science and provides access to a better understanding of biology across many orders of magnitude in time and space. The use of visible light allows for minimally invasive imaging - even of living cells - and direct observation with the human eye. However, the use of visible light limits the resolution of the image obtained to about half the wavelength of the used light. The limiting ...
DISPLAY IN CONDITIONS OF BRIGHT AMBIENT LIGHT
Ref.-Nr.: 1305-5612-WT
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Dual Inhibition of plexin-B1 and plexin-B2
Ref.-Nr.: 0603-5770-IKF
Medizin : Therapeutika
A novel molecular target of the semaphorin-plexin system to develop treatment options for cancer and for osteoporosis.
Dynamic control of three-dimensional light distributions through wavefront engineering: hardware and software system
Ref.-Nr.: 0202-5001-LI
Analytik
IT / Software / Bioinformatik

Engineering light distributions in a three-dimensional volume to achieve selective illumination profiles is an instrumental task shared by many optical and microscopy techniques. The optimization of the light distribution can lead to significant enhancement of relevant performance figures and ultimately to the extension of the instrument or experimental protocol capabilities1,2,3,4,5. Targeted illumination profiles can be used either to mechanically interact with molecules at nanometer ...
Dynamic Parallel Imaging: New Method for Accelerated MR Imaging
Ref.-Nr.: 0107-5654-BC
Bildgebung und Mikroskopie

The invention relates to a new method to reduce acquisition time in MR imaging. It is based on the variation of the sensitivity profile of the RF coils and allows an easy access to an additional source of spatial information to further improve imaging.
MR imaging is among the most important tools for modern medical diagnostics with a unique range of applications. The imaging duration however limits the applicability for situations with movements within the volume of interest. Therefore, many ...
Weiterlesen … Dynamic Parallel Imaging: New Method for Accelerated MR Imaging
eeFILM – Extended Excitation for Faster Measurement of Fluorescent Lifetimes
Ref.-Nr.: 0707-5026-BC
Sensoren, Geräte und Komponenten

The estimation of excitation lifetimes based on fluorescence or phosphorescence emission is an essential technique in basic and applied science. It provides information on molecular interactions
as well as on physical properties. Measuring the emission lifetime with spatial resolution provides an imaging modality, which in case of fluorescence is called Fluorescence Lifetime Imaging (FLIM). FLIM is applied extensively in biological imaging in order to determine the conformation, activation, ...
Weiterlesen … eeFILM – Extended Excitation for Faster Measurement of Fluorescent Lifetimes
Efficient Optical Readout: Highly Versatile Chemical Sensor
Ref.-Nr.: 0104-6343-BC
Sensoren, Geräte und Komponenten

The invention relates to an innovative detector concept for the identification of analytes in a gas that is extremely versatile and yet easy to construct and to operate. The superior properties were reached by an optical readout system for electrical signal of multiple detector cells.
Detecting and quantifying concentrations of analytes of interest is usually achieved using materials that change their electrical properties upon exposure. As different materials combined in one sensor need ...
Weiterlesen … Efficient Optical Readout: Highly Versatile Chemical Sensor
Electroluminescence Imaging Evaluation: Software EL-Fit
Ref.-Nr.: 1401-4175-WT
IT / Software / Bioinformatik
This software is based on the paper "Quantitative evaluation of electroluminescence images of solar cells" by O. Breitenstein et al.1). It allows to load a number of electroluminescence (EL) images to different biases, which have to be given as ASCii tables.
Weiterlesen … Electroluminescence Imaging Evaluation: Software EL-Fit
Electron Microscopy: Ready to Use AI for Focus and Astigmatism Adjustment
Ref.-Nr.: 0202-6337-BC
Bildgebung und Mikroskopie

The invention relates to a new method for imaging setting optimization for electron microscopy
based on deep learning. The AI is a robust and simple to implement optimization possibility for
direct operation with various types of electron microscopes.
For a wide spectrum of applications automated precision electron microscopy is a powerful
method. Existing auto focusing routines are often based on physical models of the microscope
and are hence lacking general applicability ...
Weiterlesen … Electron Microscopy: Ready to Use AI for Focus and Astigmatism Adjustment
Enhancement resonator including non-spherical mirrors
Ref.-Nr.: 1202-4590-WT
Sensoren, Geräte und Komponenten

An Enhancement Cavity (EC) with at least one toroidal and/or cylindrical mirror is described. This allows for an arbitrary beam ellipticity of the eigenmode. In particular at a stability edge, where the ellipticity diverges with purely spherical optics, a round beam can be obtained.
Weiterlesen … Enhancement resonator including non-spherical mirrors
Environmental Monitoring: Detection of Atmospheric Particulate Matter PM2.5
Ref.-Nr.: 1629-5711-WT
Sensoren, Geräte und Komponenten

The invention relates to a new and durable system, which brings the possibility of accurate size measuring and simultaneous counting of airborne particles with an aerodynamic diameter of up to 2.5 microns.
Measuring the particulate matter contamination in a gas in the range of PM2.5 is advantageous or crucial for various applications. Monitoring the concentration of the corresponding particles, for example in air, reveals information about pollution. The possibility of aerosol ...
Weiterlesen … Environmental Monitoring: Detection of Atmospheric Particulate Matter PM2.5
Exergy Efficient Chlorine Separation
Ref.-Nr.: 1402-5465-LC
Prozesse und Methoden (inkl. Screening) : Chemische

Three novel processes to separate Cl2 from unconverted HCl in the anode outlet stream of a electrochemical gas-phase reactor were developed at the MPI for Dynamics of Complex Technical Systems. The novel processes lead to a higher reaction yield in gas-phase reactor and have an reduced energy demand compared to the Bayer UhDenora state-of-the-art process.
Exploitation of mineral cesium from mineral sources
Ref.-Nr.: 0042-5371-LC / SGK A477
Prozesse und Methoden (inkl. Screening)
Medizin

Prof. Klaus-Richard Pörschke and co-workers at the MPI for Coal Research developed a novel cyclic process for the quantitative extraction of cesium with 100% selectivity from any given aqueous or acidic solution, irrespective of the other components.
Weiterlesen … Exploitation of mineral cesium from mineral sources
Extraction of nanocellulose from cellulose pulp in reactive eutectic media
Ref.-Nr.: 0401-5970-LC
Prozesse und Methoden (inkl. Screening)
Neue Materialien

A novel green chemistry process to prepare nanocellulose in efficient, safe and sustainable manner based on the use of eutectic, highly concentrated ionic media is offered.
Weiterlesen … Extraction of nanocellulose from cellulose pulp in reactive eutectic media
f-Chrimson and vf-Chrimson, two ultrafast variants of the red-light activated channelrhodopsin Chrimson
Ref.-Nr.: 0601-5208-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues, and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...
Fabrication of ultrathin nano-porous membranes and semiconductor nanowires
Ref-Nr.: 0104-4458-GÖ
Bildgebung und Mikroskopie
Neue Materialien

Semiconductor nanowires are of vital importance for many applications, such as flexible electronics, photonics, sensors, and energy harvesting and storage devices. As standard fabrication procedure, vapor-liquid-solid (VLS) growth employs metal catalyst particles (such as gold) as seeds for growth of nanowires. The seeds are deposited on a solid substrate, melted by heating and then exposed to a gas atmosphere containing source materials of the semiconductor. When the metal droplets are supersaturated, ...
Weiterlesen … Fabrication of ultrathin nano-porous membranes and semiconductor nanowires
Fast and efficient protein purification form prokaryotic and eukaryotic hosts
Ref.-Nr.: 0109-4896-LI
Prozesse und Methoden (inkl. Screening)
Fusion Tags Comprising Ubiquitin-like Modifiers and Corresponding Proteases For Protein Purification From Selected Eukaryotic Expression Hosts
Weiterlesen … Fast and efficient protein purification form prokaryotic and eukaryotic hosts
Fast Photodetector with Intrinsic Amplification: Avalanche Photodiode Array
Ref.-Nr.: 1201-5750-BC
Sensoren, Geräte und Komponenten

The invention relates to a new monolithic Avalanche Photodiode array with a novel inter pixel isolation structure. The technology allows the design of sensitive photodetectors with remarkable spatial resolution at very fast imaging capabilities for various applications.
Although Avalanche Photodiodes are a convenient tool due to their intrinsic amplification, their use in photodetectors with high pixel densities is challenging due to insufficient isolation of the pixels. Hence their use in ...
Weiterlesen … Fast Photodetector with Intrinsic Amplification: Avalanche Photodiode Array
Faster Processing: Neural Network for MR Imaging Parameter Prediction
Ref.-Nr.: 0107-6054-BC
Bildgebung und Mikroskopie

The invention relates to a new method for processing magnetic resonance (MR) data based on a neural network (NN). After training, the NN quickly delivers high quality CEST images with low computational effort. Additionally, it provides uncertainty data aiding to judge the images appropriately.
Typically, sophisticated MR contrasts are calculated based on complex mathematical models, which is computationally expensive, and it requires long processing durations. Besides that, the results ...
Weiterlesen … Faster Processing: Neural Network for MR Imaging Parameter Prediction
FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Ref.-Nr.: 0603-4987-IKF
Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.
Weiterlesen … FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies
Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)
Ref.-Nr.: 0707-4198-BC
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) is nowadays a leading mo¬dality for diagnostic imaging with about 100 million examinations per year worldwide. However, when invented by Paul Christian Lauterbur in 1973, MRI was too slow to allow for routine medical applications. A breakthrough was achieved in 1985 by the FLASH (Fast Low Angle Shot) technique developed by Jens Frahm and his team at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Germany. With FLASH the measuring time for a cross-sectional ...
Weiterlesen … Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)
FlipDroppy household dispenser for powders and granular food
Ref.-Nr.: 0109-6297-LI
Sensoren, Geräte und Komponenten

Accurate dispensing device for intuitive, spill free use
Weiterlesen … FlipDroppy household dispenser for powders and granular food
FlipDroppy laboratory dispenser for solid particles, powders, and beads
Ref.-Nr.: 0109-6297-LI
Sensoren, Geräte und Komponenten

An accurate dispensing device for powders and irregularly shaped particles
Weiterlesen … FlipDroppy laboratory dispenser for solid particles, powders, and beads
Generation of induced pluripotent stem cells with one or two reprogramming factors
Ref.-Nr.: 1012-3916-LI
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
The cellular identity of mature cells that are confined in a specialized genetic expression profile can be overcome by introducing just a few genes that encode for so-called reprogramming factors [1]. By means of this intervention, also known as reprogramming, the cells then become pluripotent and represent induced pluripotent stem cells (iPS cells) [1]. Nowadays, numerous new cell culture models have been established based on reprogramming protocols that yield iPS cells. Such cell culture models ...
Weiterlesen … Generation of induced pluripotent stem cells with one or two reprogramming factors
Generation of RNA therapeutics by conjugating NAD-capped RNAs to proteins
Ref.-Nr.: 0706-6285-IKF
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Conjugation of a NAD-capped nucleic acid to a protein catalysed by an ART to generate novel RNA therapeutics.
Weiterlesen … Generation of RNA therapeutics by conjugating NAD-capped RNAs to proteins
Genome-Editing-Technologies - Cas9 double mutant with improved specificity compared to wild-type
Ref.-Nr.: 0306-5787-LI
Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien
The RNA-programmable DNA-endonuclease Cas9 is widely used for genome engineering, where a high degree of specificity is required. Though this is a mechanism well controlled by canonical base-pairing, there is evidence that Cas9 does accept mismatches under certain circumstances.
This might be seen as a threat to precision needed in genome engineering at least in environments where such high precision is ultimately needed and acceptance of mismatches needs to be avoided, e.g.: cellular gene ...
Genome-Editing-Technologies - Single compound or compound mix dramatically improve Homology-Directed-Repair (HDR)
Ref.-Nr.: 1306-5734-LI & 1306-5288-LI
Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien
Precise genome editing demands for homology-directed repair (HDR) by aiming to introduce a new double stranded DNA substituting for a homologous sequence but partially defect one. This substrate dependent reaction does compete with direct non-homologous end joining (NHEJ) of the double strand breaks. NHEJ is error-prone and is therefor mainly used for gene inactivation.
The rate of NHEJ is directly limiting the rate of HDR. For this reason HDR in vitro does occur on a very low level only and ...
Glue your proteins of interest together: Fast and ultra-specific enzymatic conjugation of a protein with another, synthetic compounds or even whole cells
Ref.-Nr.: 0109-5804-LI
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
Connectase is an enzyme that fuses target proteins or synthetic compounds via a small recognition tag, using a different reaction mechanism compared to known protein ligases. It prevents side reactions entirely and has absolute specificity, even in highly in complex solutions with minimum concentrations of target molecules.
GOLD gRNA - allows robust genome editing regardless of spacer sequence composition by super stable hairpin technology
Ref.-Nr.: 1306-6101-LI
Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien
A Cas nuclease such as Cas9 can introduce a DNA double strand break in a sequence target that is complementary to a 20-nt spacer sequence of its bound guide RNA (gRNA) when a protospacer adjacent motif (PAM) is present. The gRNA can be provided as duplex of spacer containing CRISPR RNA (crRNA) and trans-activating crRNA (tracrRNA). Or as a single gRNA (sgRNA) where crRNA and tracrRNA are fused by an artificial loop.
Hence a gRNA consists of the target-specific spacer and a constant part typically ...
Graphene Balls and electrochemical cells containing these materials
Ref.-Nr.: 0903-4524-LC
Neue Materialien

We offer a new simple and low cost technology to fabricate graphene-encapsulated metal or metal compound nanoparticles. The resulting hybrid nanoparticles are protected by granted substance claims in US, CN, TW and EP (DE, FR, GB, BE). Currently the patent protected graphene coated nano particles are discussed as high performance electrode materials in the lithium ion battery business (for example Samsung's "Graphene Balls").
Weiterlesen … Graphene Balls and electrochemical cells containing these materials
High efficiency hydrodynamic collimation vacuum interface for atmospheric pressure ion sources
Ref.-Nr.: 1201-4433-BC
Sensoren, Geräte und Komponenten

In mass spectroscopy, many ion sources that transform the specimen to be tested into gas phase ions operate at ambient or elevated pressure. The generated ions have to be transferred into vacuum for further characterization, for instance in a mass analyzer.
The ion transfer into vacuum represents a major bottleneck. Because the pumping power increases rapidly with the size of an opening, long capillaries or small pinholes have to be used. Their transmission is commonly as low as 1%, in optimal ...
High Ferroelectricity: First Method for Production of Bulk SnTiO3
Ref.-Nr.: 1201-5559-BC
Neue Materialien

The invention relates to a new method of producing SnTiO3 for the use as a ferroelectric element. Tin titanates are known to be a class with various properties making it promising for many applications. The preparation of this material beyond thin films remained challenging.
Tin(II) oxide has a low disproportionation temperature of 350°C but the preparation of new materials is usually conducted at higher temperatures. Therefore, bulk SnTiO3 is not possible to be produced using existing ...
Weiterlesen … High Ferroelectricity: First Method for Production of Bulk SnTiO3
High-precision base editors for site-specific single nucleotide conversion
Ref.-Nr.: 0402-5782-MG
Prozesse und Methoden (inkl. Screening)
The CRISPR-Cas system is a powerful tool for site-specific genome editing. It allows for the inactivation or substitution of entire genes. However, most hereditary diseases in humans are caused by single point mutations, the correction of which requires only subtle changes to the DNA. Recently, base editors (BEs) were developed that allow the introduction of selective nucleotide substitutions. A Cas9 enzyme is fused to a nucleobase deaminase catalysing C-to-T mutations (by C-to-U deamination) ...
Weiterlesen … High-precision base editors for site-specific single nucleotide conversion
Higher Power Output and Simple Setup: New Source of Terahertz Radiation
Ref.-Nr.: 1201-6201-BC
Sensoren, Geräte und Komponenten

A novel concept for an efficient source of terahertz radiation was developed that is simple, powerful, and easy to use. It improves the possibilities to use THz radiation in science, medicine, security, communications, and other specialized applications.
THz radiation is expected to have high potential in various fields of science and technology. However, respective sources typically require highly specialized and complicated components like single crystals or cryogenics. Furthermore, a ...
Weiterlesen … Higher Power Output and Simple Setup: New Source of Terahertz Radiation
Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
Ref.-Nr.: 1013-4990-IKF
Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.
Weiterlesen … Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity
Hybrid Thin-Disk Amplifier
Ref.-Nr.: 1202-4510-WT
Sensoren, Geräte und Komponenten

Ultrafast amplifier systems providing high average powers (>10W) at repetition rates in the kHz regime suffer from severe accumulation of nonlinear phase inside the laser gain medium and other optical components within the amplifier. Implementation of chirped pulse amplification (CPA) constitutes a well-established method to reduce the peak intensity of the laser pulse during the amplification process [1, 2]. However, state of the art laser materials supporting high average output powers such ...
Improved Safety: Real-Time Monitoring of Thermal Power of a Nuclear Reactor
Ref.-Nr.: 0102-5836-WT
Sensoren, Geräte und Komponenten

The invention relates to a new and easy to use device for real-time monitoring of the thermal power of a nuclear reactor. It is based on the easy to access 16N decay rate in the cooling water. The robust and easy to implement method significantly improves the safety of nuclear facilities.
Nuclear reactors require high standards of safety and detailed information about changes are needed in order to control them in a safe manner. Besides detailed real-time simulations, direct ...
Weiterlesen … Improved Safety: Real-Time Monitoring of Thermal Power of a Nuclear Reactor
LABEL-FREE SEPARATION AND ANALYSIS OF MACROMOLECULES
Ref.-Nr.: 1629-4734-WT
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten
Photonics

Weiterlesen … LABEL-FREE SEPARATION AND ANALYSIS OF MACROMOLECULES
Laser device with kerr effect based mode-locking and operation thereof
Ref.-Nr.: 1202-4422-WT
Sensoren, Geräte und Komponenten

A laser device (100), configured for generating laser pulses, has a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12). The laser resonator (10) includes a first mode shaping section (13) which is adapted for shaping a circulating electric field coupled into the gain disk medium (11), and a second mode shaping section (14), which is adapted for shaping the circulating electric field coupled into the Kerr medium (12) independently of the electric field shaping in the first ...
Weiterlesen … Laser device with kerr effect based mode-locking and operation thereof
Leaf metabolites as markers for mycorrhizal colonization of plant roots
Ref.-Nr.: 1602-5392-LI
Grüne Biotechnologie

Screening the level of specific blumenols in plant leaves allows simple implementation in marker assisted breeding and high-throughput analysis.
Weiterlesen … Leaf metabolites as markers for mycorrhizal colonization of plant roots
LITESEC - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
Ref.-Nr.: 0706-5707-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Arzneimittel-Darreichung
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.
Localized Oscillating Magnetic Fields: New Method for Accelerated MR Imaging
Ref.-Nr.: 0107-5557-BC
Bildgebung und Mikroskopie

The invention relates to a new method to reduce acquisition time in MR imaging. It is based on the use of localized temporal modulations of the main magnetic fields which provides further spatial information from the resonance signal. The method can be applied to parallel imaging.
MR imaging is among the most important tools for modern medical diagnostics with a unique range of applications. The imaging duration however limits the applicability for situations with movements within the volume ...
Weiterlesen … Localized Oscillating Magnetic Fields: New Method for Accelerated MR Imaging
Lock-in thermography evaluation software for solar cells – Local I-V 2 (replacing Local I-V)
Ref.-Nr.: 1401-4359-WT
IT / Software / Bioinformatik
The efficiency of solar cells is strongly affected by local inhomogeneities. Especially inhomogeneities of the dark-current voltage (I-V) characteristic are of interest: The local dark current-voltage characteristic is a measure for the local recombination properties of the solar cell. Lock-in thermography performed in the dark (DLIT) can be used to detect and evaluate locally increased dark current densities.
MARS – software for robust and automatic backbone assignment of protein NMR spectra
Ref.-Nr.: 0707-5990-MG
IT / Software / Bioinformatik
MARS is a powerful program for robust automatic backbone assignment of proteins. MARS is applicable to proteins with extreme chemical shift degeneracy such as high molecular weight proteins and partially disordered or fully intrinsically disordered proteins. MARS is successfully used in many labs world-wide as evidenced by a huge number of citations.
Weiterlesen … MARS – software for robust and automatic backbone assignment of protein NMR spectra
Method and apparatus for optical frequency comb generation using a monolithic micro-resonator
Ref.-Nr.: 1202-3760-WT
Sensoren, Geräte und Komponenten
The invention relates to a monolithic optical frequency comb generator. Furthermore, the invention relates to a method of generating an optical frequency comb.
Method and radiation source for generating pulsed coherent radiation
Ref.-Nr.: 1302-3482-WT
Sensoren, Geräte und Komponenten
The present invention relates to a method of generating pulsed coherent radiation in the UV and XUV wavelength ranges. Furthermore, the present invention relates to a radiation source for generating pulsed coherent radiation based on a high harmonic generation (HHG).
Weiterlesen … Method and radiation source for generating pulsed coherent radiation
Method for cell-free protein synthesis assays or other fluorescent assays in the context of cell-free protein synthesis
Ref.-Nr.: 0204-5479-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

An improved method to perform cell-free protein synthesis (CFPS) assays or other fluorescent assays in the context of CFPS with very low reaction mix volumes. Various additional advantages allow to significantly reduce costs and time.
METHOD FOR PRODUCING RANDOM NUMBERS ON THE BASIS OF QUANTUM NOISE
Ref.-Nr.: 1629-5565-WT
Sensoren, Geräte und Komponenten
Photonics

The invention relates to a new method for an improved production of random numbers and verification of their randomness. In order to do so, it uses the quantum mechanical properties of microscopic particles and structures. A number sequence is generated by means of a repetitive quantum mechanical random process. The measurement of this process is performed by a homodyndetection of an optical input signal, where the signal interferes with a local oscillator, e.g. a laser, at a central beam splitter ...
Weiterlesen … METHOD FOR PRODUCING RANDOM NUMBERS ON THE BASIS OF QUANTUM NOISE
Method for quantitative analysis of electrostatic charging of a specimen
Ref.-Nr.: 0601-6026-BC
Sensoren, Geräte und Komponenten

Weiterlesen … Method for quantitative analysis of electrostatic charging of a specimen
METHOD OF GENERATING LASER PULSES USING THE TEMPORAL TALBOT EFFECT
Ref.-Nr.: 1202-5266-WT
Sensoren, Geräte und Komponenten
Photonics

Weiterlesen … METHOD OF GENERATING LASER PULSES USING THE TEMPORAL TALBOT EFFECT
Method of producing autotrophic microorganisms with altered photorespiration and improved CO2 fixation
Ref.-Nr.: 0706-5602-IKF
Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Biological fixation of CO2 is an important process carried out by plants and several microorganisms, which can be harnessed for sustainable, biobased production of fuels and chemicals. Particularly, the fixation of CO2 by autotrophic microorganisms such as cyanobacteria and microalgae can be employed for converting CO2 into value-added products, such as commodity chemicals or fuels. However, the sustainable autotrophic production ...
Microfluidic cryo-fixation of biomass, e.g., cells, flagella/cilia, or proteins for (in particular) correlative light-electron microscopy systems
Ref.-Nr.: 0707-4032-BC
Bildgebung und Mikroskopie

Cryo-Electron Microscopy (Cryo-EM) today is revolutionizing biological research by revealing the structure of cells and proteins with atomic resolution and steadily improving contrast. However, the quality of the results depends critically on the sample preparation. High Pressure Freezing (HPF) and plunge freezing, both pioneered in the 1960s, still represent the state-of-the-art in sample preparation for cryo-EM. Both methods have poor timing precision, disrupt the natural environment of the ...
Milestone for Plasmonics: The Plasmon Generating Transistor
Ref.-Nr.: 1201-4765-BC
Sensoren, Geräte und Komponenten

The invention relates to a new method for a plasmon emitting transistor that operates in the single quantum regime. It is a major step towards future data processing technology that is no longer based on electric currents but on the transition of light.
Developments over past decades have gradually increased the performance of computer chips, but new technologies are needed to overcome the sizing limit of classical transistors. Replacing the role of electrical currents by the use of light ...
Weiterlesen … Milestone for Plasmonics: The Plasmon Generating Transistor
Modular low light level sensors: a scalable approach
Ref.-Nr.: 0206-5874-BC
Sensoren, Geräte und Komponenten : Sensoren

A scalable and easy to handle method for the creation of larger (up to square meters) low light level detectors is disclosed. While the fast read-out times of a single detector is kept, the area covered by the detector ensemble (dramatically) increases. The large area is enabled by transversal connection of hybrid “base cells”. These “base cells” consist of vertically stacked tiers of (i) a detector array, (ii) a first level electronic read-out, and (iii) and a second level read-out which ...
Weiterlesen … Modular low light level sensors: a scalable approach
Molecularly defined non-infectious synthetic virus-like particles to mimic biophysical features of natural pathogens
Ref.-Nr.: 0105-6291-IKF
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A synthetic virus-like particle, comprising a lipid bilayer, that can be adjusted precisely to mimic biophysical features of various natural pathogens. The lipid bilayer can also be equipped with relevant molecules such as the SARS-CoV-2 spike protein ectodomain.
Monoclonal Antibody to Detect Neutrophil Extracellular Traps via a Novel Post Translational Histone Modification
Ref.-Nr.: 0305-5699-LI
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Antikörper
A novel tool to detect and quantify NETs using a molecular feature of NET formation that has never been proposed as a marker for NETs before
Mouse model for mitochondrial diseases
Ref.-Nr.: 1013-4827-IKF
Medizin : Tiermodelle
Forschungs-Reagenzien
A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.
Multi-well Exosome Libraries for High-throughput In Vitro Cell Activity Assays
Ref.-Nr.: 0707-6429-MG
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
Extracellular vesicles (EVs) such as exosomes and microvesicles participate in the intercellular communication by transferring bioactive molecules between various cells and tissues. Such EVs cross-talk was shown to play important roles in cell–cell communication, cell maintenance, disease progression and therapy. By containing disease specific markers, EVs can also act as diagnostic biomarkers. In addition, synthetic EVs are used as carriers to deliver drugs or mRNA-based vaccines to specific ...
Weiterlesen … Multi-well Exosome Libraries for High-throughput In Vitro Cell Activity Assays
Multichannel coil for UHF MRI
Ref.-Nr.: 0107-4677-BC
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Exploiting the benefits offered by magnetic resonance imaging (MRI) at ultra-high fields (≥ 7 Tesla) requires optimized radiofrequency (RF) coils. MRI at UHF operates in a regime where the RF wavelength is comparable to the dimensions of the sample size, resulting in an inhomogeneous distribution of the transmit field (B1+) and in an impaired image quality. An array of independent transmit coils arranged in multiple rows provides the degrees of freedom to influence the ...
Multifunctional RFID-based Platform for Animal Observation and Manipulation
Ref.-Nr.: 0214-5247-MG und 0214-5440-MG
IT / Software / Bioinformatik : (andere) Software
Sensoren, Geräte und Komponenten : Sensoren
Sensoren, Geräte und Komponenten : Geräte
Sensoren, Geräte und Komponenten : Komponenten

An efficient system to monitor and control animal behavior in wildlife as well as in laboratory settings
Weiterlesen … Multifunctional RFID-based Platform for Animal Observation and Manipulation
N-substituted pyridiniophosphines, processes for their preparation and their use
Ref.-Nr.: 0042-4938-LC-WA
Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien
We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.
Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.
Weiterlesen … N-substituted pyridiniophosphines, processes for their preparation and their use
Nanographene-based dyes as high performance probes for super-resolution microscopy
Ref.-Nr.: 0903-5658-LC; 0903-5696-LC
Analytik
Bildgebung und Mikroskopie
Neue Materialien

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).
They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.
These nanographene ...
Weiterlesen … Nanographene-based dyes as high performance probes for super-resolution microscopy
Near-Unity Efficiency: Novel Light Collecting Antenna for Quantum Technologies
Ref.-Nr.: 1629-6049-WT
Photonics
The invention relates to a new concept for a high efficiency light antenna, namely the Truncated Omnidirectional Reflector (TOR). It is well suited for obtaining directional emission and efficient fiber coupling from various types of light sources like single photon emitters.
Especially in the fast-growing field of quantum technologies efficient collectors for solid-state single photon emitters are needed. Achieving collector efficiencies of more than 95% into the fundamental Gaussian mode, ...
Weiterlesen … Near-Unity Efficiency: Novel Light Collecting Antenna for Quantum Technologies
Neuro-epithelial stem cells (NESC) capable of forming both central nervous system (CNS) and peripheral nervous system (PNS) neurons
Ref.-Nr.: 1012-4430-LI
Prozesse und Methoden (inkl. Screening)
File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)
A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.
New KDAC assay and selection system
Ref.-Nr.: 0803-5480-IKF
Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

We present an extremely sensitive, reliable and fast novel Lysine deacetylase (KDAC) assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion.
We furthermore offer a bacterial selection system that can help engineer KDACs. The selection system uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby ...
Noise Free Imaging: Incoherent Light Source for Microscopy
Ref.-Nr.: 1629-5817-WT
Bildgebung und Mikroskopie

The invention relates to a new light source exhibiting a high level of spatial incoherence. This enables microscopic imaging with reduced artefacts and low intensity noise. It comprises a pulsed laser whose beam properties are improved is by a multimode optical fiber.
Full field microscopic imaging is an essential technique in medicine and beyond, but the occurrence of noise strongly limits its applicability. Coherent light contributes considerably to the formation of artefacts. Hence the ...
Weiterlesen … Noise Free Imaging: Incoherent Light Source for Microscopy
Non-collinear spin-valve
Ref.-Nr.: 1201-5998-BC
Sensoren, Geräte und Komponenten

A classical spin valve (SV) is a device in which the electrical resistance depends on the relative position of the magnetic moments of two ferromagnetic (FM) layers: with parallel (P) and antiparallel (AP) ordering, the SV resistance is minimum and maximum, respectively. Nowadays SVs are actively used in magnetic sensors, hard disk read heads and magnetic random-access memory. Thus, the SV, analogous to a transistor in conventional electronics, is a binary (digital) device. Here we offer a new ...
Novel biomarker for diagnosis and targeted therapy of Acute Myeloid Leukemia (AML)
Ref.-Nr.: 0204-6248-MG
Medizin : Diagnostika
New biomarker candidates for diagnostic sub-classification of AML patients with elevated expression of mitochondrial proteins and subsequent targeted therapy with BCL-2 inhibitors like venetoclax and/or agents targeting mitochondrial complex I
Weiterlesen … Novel biomarker for diagnosis and targeted therapy of Acute Myeloid Leukemia (AML)
Novel Biomarkers for Ageing and Metabolic Health
Ref.-Nr.: 1013-5354-IKF
Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.
Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...
Weiterlesen … Novel Biomarkers for Ageing and Metabolic Health
Novel compounds for plant disease control
Ref.-Nr.: 0707-5356-MG
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Grüne Biotechnologie
Plant pathogenic fungi, oomycetes and bacteria have highly diverse lifestyles, infection strategies and morphologies. Therefore, pesticides frequently target basic cellular processes, as these are well characterized and often very similar among plant pathogens. Many pesticides target enzymes that play a role in e.g. nucleic acid synthesis, respiration, cell division and other essential cellular processes. However, the molecular ...
Novel Lignin Nanocarriers for Smart Drug Delivery in Crop Protection
Ref.-Nr.: 0903-4955-LC
Grüne Biotechnologie

The Max Planck Institute for Polymer Research in collaboration with the Institute of Biotechnology and Drug Research (IBWF) developed novel lignin nanocarriers that can be used for smart pesticide delivery in plants for crop protection. The nanocarriers are characterised by a narrow size distribution and an easy manufacturing, furthermore, they can be loaded with hydrophobic pesticides. Injected to plants, the nanocarriers act as a safe store of pesticide, which is released in situ by lignin degrading ...
Weiterlesen … Novel Lignin Nanocarriers for Smart Drug Delivery in Crop Protection
Novel method for analysis of complex carbohydrate structures by ion-mobility mass spectrometry (IM-MS)
Ref.-Nr.: 0401-5070-MG
Analytik
Carbohydrates form one of the major classes of biological macromolecules in living organisms, but structural analysis and the quality control of carbohydrate structures represent a major challenge due to the frequent occurrence of isomers that are difficult to distinguish using established techniques.
Changes in protein glycosylation are frequently identified in the context of diseases. For example, alterations in N-glycan profiles from blood plasma have been found to correlate with pathological ...
OPTICAL RESONATOR WITH GEOMETRICAL ACCESS TO THE OPTICAL AXIS
Ref.-Nr.: 1202-4309-WT
Sensoren, Geräte und Komponenten
Photonics

Weiterlesen … OPTICAL RESONATOR WITH GEOMETRICAL ACCESS TO THE OPTICAL AXIS
Optimised Flow-Through-Cell for Online-Microscopy
Ref.-Nr.: 1402-5292-BC
Neue Materialien

For the evaluation of crystallisation processes, process parameters like temperature and concentration can be easily measured. However, to measure the crystal size distribution continuously is a challenging task.
Different methods relaying on back scattering or reflection of monochromatic light can be applied that yield chord-length distributions, which often deviate from the actual crystal or particle size distribution. For analysing the true crystal dimensions and, additionally, the crystal ...
Weiterlesen … Optimised Flow-Through-Cell for Online-Microscopy
Optimization of Multi-Channel Coil for Magnetic Resonance Imaging
Ref.-Nr.: 1302-4127-BC
Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) requires optimal radio-frequency (RF) coil performance that ensures the highest RF magnetic field per unit power delivered to the coil, while maintaining the highest achievable RF field homogeneity. For MRI at high magnetic field level, it is important to use a multi-channel transmit coil for producing the desired RF field. However, it is impossible to design a multi-channel coil without considerable coupling between its coil elements. The major challenge in multi-channel ...
Weiterlesen … Optimization of Multi-Channel Coil for Magnetic Resonance Imaging
Organotextile Catalysis
Ref.-Nr.: 0042-4764-LC-WA
Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

An easy process for the facile and permanent immobilization of organocatalysts on nylon textiles was developed.
All of the prepared textile-immobilized organocatalysts (a Lewis basic, a Brønsted acidic, and a chiral organocatalyst) display excellent stability, activity and recyclability for various organic transformations. Very good enantioselectivity (>95:5 enantiomeric ratio) can be maintained for more than 250 cycles of asymmetric catalysis. The flexible construction of fabrics allows ...
Overcoming disease persistence in myeloproliferative neoplasms (MPN) through combinatorial inhibitor treatment
Ref.-Nr.: 0204-5895-MG
Medizin : Therapeutika
The mRNA processing factor YBX1 is a novel target in Myeloproliferative neoplasms (MPNs), which in an combinatorial inhibitor treatment with JAK inhibitors completely overcomes disease persistance.
PALES software package
Ref.-Nr.: 0707-5926/6382-MG
IT / Software / Bioinformatik : Bioinformatik
NMR spectroscopy is a unique technique for the assignment of the constitution, configuration and conformation of small molecules, natural products, proteins, nucleic acid and oligosaccharides. NMR-derived residual dipolar couplings overcome limitations associated with traditional NMR data, avoid data misinterpretation and provide novel insights into structure-activity relationships. In order to leverage the full potential of residual dipolar couplings, however, powerful dedicated software and ...
Parallel glycan synthesis on a membrane
Ref.-Nr.: 0401-5724-MG
Prozesse und Methoden (inkl. Screening) : Produktion

A process for parallel synthesis of glycans on cellulose membranes by using a novel VaporSPOT method and an experimental setup that ensures controlled conditions suitable for glycosylation reactions.
Parallel-imaging time-of-flight momentum microscope
Ref.-Nr.: 1401-4572-WT
Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten : Geräte

The state of an electron is completely defined by its momentum and spin. In processes like electron diffraction or photoemission electron ensembles are generated which have a characteristic 3D distribution of momentum and spin. To examine such events the three components of the momentum vector have to be measured. Up to now, the momentum distribution of an ensemble of charged particles was typically measured using energy-dispersive spectrometers based on sequential approaches (sequentially changing ...
Weiterlesen … Parallel-imaging time-of-flight momentum microscope
Peptides and methods for carbon-carbon bond formation
Ref.-Nr.: 0706-5856-IKF
Prozesse und Methoden (inkl. Screening) : Chemische
One of biotechnology’s central goals is the synthesis of multicarbon compounds under mild and sustainable conditions from renewable resources. This requires biocatalysts and methods that enable selective C-C bond formation (carboligation) between two carbon units.
Moreover, optically active compounds can be used for optically resolving agents of medical or agriculture supplies such as 2-amino-1-butanol which is a starting material of the antituberculous drug ethambutol, diltiazem hydrochloride ...
Weiterlesen … Peptides and methods for carbon-carbon bond formation
PLAYFUL Reactive Programming for Orchestrating Robotic Behavior
Ref.-Nr.: 0104-5603-BC
IT / Software / Bioinformatik

Playful is a scripting language for orchestration of Python modules. Playful allows developers to both organize the logic of activation in reactive behaviour tree and setup sensory-motor couplings, making it especially useful for robotics
Weiterlesen … PLAYFUL Reactive Programming for Orchestrating Robotic Behavior
PONy Dyes – Fluorescent Dyes with Phosphorus Substituents
Ref.-Nr.: 0707-5297-BC
Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. In particular, the sensitive and stable imaging of cellular components depends on the favourable combination of chemical, biological and physical factors. The availability and proper choice of fluorescent dyes is a key factor to success in the entire labelling and imaging procedure. Due to their superior brightness and photostability, synthetic dyes represent an attractive alternative ...
Weiterlesen … PONy Dyes – Fluorescent Dyes with Phosphorus Substituents
Precise LIDAR Devices: Metasurface for Large-Angle Beam Steering
Ref.-Nr.: 1201-6235-BC
Photonics

The invention relates to a new device for precise large-angle beam steering at an extended wavelength range. It is based on an electrically-controlled metasurface and allows for the implementation in advanced LIDAR systems.
Metasurfaces are used to change properties of light and can therefore be used to steer an incoming beam. However, common devices are lacking spatial resolution and are thus limited to small angles. Furthermore, state-of-the-art metasurfaces for respective applications ...
Weiterlesen … Precise LIDAR Devices: Metasurface for Large-Angle Beam Steering
Precision Microscopy: Detector for Changes in Direction of a Light Beam
Ref.-Nr.: 0105-5623-BC
Bildgebung und Mikroskopie
The invention relates to a new method for light beam angle detection that is based on interferometry. High precision and sensitivity for slight changes of the beam direction can be achieved with this method.
For high precision light microscopy, the light beam must be aligned accurately, and the beam direction stability must be ensured in order to maintain a sufficient imaging resolution over longer periods of time. In standard microscopy environments even small temperature changes can result ...
Weiterlesen … Precision Microscopy: Detector for Changes in Direction of a Light Beam
Predicting concentrations, reactions rates and rate constants in biochemical networks
Ref.-Nr.: 0402-5469-MG
Analytik
IT / Software / Bioinformatik : Bioinformatik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.
Weiterlesen … Predicting concentrations, reactions rates and rate constants in biochemical networks
Process for producing a mesoporous carbide
Ref.-Nr.: 0041-4518-WT
Neue Materialien
Mesoporous materials present a large surface-to-volume ratio providing sites for catalysis, molecular separation, adsorption or chemical sensing. Some of the classical mesoporous materials employed include silica, alumina, zirconia, zeolites, and other diverse oxides such Ti or Co, and they are synthetized by routes as self-assembly, sol-gel, spray drying and some variations of these methods known in the state of the art. Additionally, some elements of the platinum group such as Pd, Ru, and their ...
Protein Cristallography (XDS)
Ref.-Nr.: 0105-1318-WT
IT / Software / Bioinformatik
X-ray Detector Software for processing single-crystal monochromatic diffraction data recorded by the rotation method.
Protein Epitope Signature Tags (PrESTs) for SILAC-based absolute protein quantification
Ref.-Nr.: 0204-4338-MG
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Direct quantification of the absolute amount of multiple proteins in one a SILAC experiment using Protein Epitope Signature Tags (PrESTs) which consist of a short and unique region of the protein of interest as well as purification and solubility tags and are expressed recombinantly in E. coli
Reducing phase singularities in speckle interferometry
Ref.-Nr.: 1629-5142-WT
Sensoren, Geräte und Komponenten : Geräte

Speckle interferometry is an established metrology technique for the characterization of rough objects. Deformations of rough objects under a load can be determined, as well as – with the help of an additional second wavelength – the surface shape of the object under test. As an illustration, Figure 1 (left) shows the so called raw phase as a result of a deformation measurement on a metal plate. The shape and the density of the fringes indicate the response of the metal plate to the load.
Owing ...
Weiterlesen … Reducing phase singularities in speckle interferometry
Reliable and Independent: New Automated Glaucoma Detection Method
Ref.-Nr.: 0705-5468-BC
Bildgebung und Mikroskopie

The invention relates to a newly developed image processing method for optical coherence tomography (OCT) to be used in particular on the (human) eye’s anterior chamber. Said OCT images are used to diagnose glaucoma, but the required assessing methods are not yet available as automated and fully unsupervised.
Glaucoma is the main reason for irreversible blindness. Early-stage diagnosis is typically based on images of the anterior chamber. Various automated techniques for image analysis ...
Weiterlesen … Reliable and Independent: New Automated Glaucoma Detection Method
Remote and Spatiotemporal Control for the Actuation of Biocompatible Membranes through the Irradiation with (visible) Laser Light
Ref.-Nr.: 0903-6221-LC
Neue Materialien

The invention relates to the actuation of micro- and nanostructures controlled by external stimuli. Photo-actuation utilizes the conversion of light via phonons into motion through reversible chemical and physical processes and enables remote and spatiotemporal control of the actuation. Here, we report a fast light-to-motion conversion in few-nanometer thick bare polydopamine (PDA) membranes stimulated by (visible) light. Light-induced heating of PDA leads to desorption of water molecules and ...
Scalable coupling part machined from one workpiece
Ref.-Nr.: 0704-5610-BC
Sensoren, Geräte und Komponenten : Komponenten

The invention describes an easy and cheap to produce, compact coupling part, manufactured out of one workpiece. This part, scalable for shaft diameters as low as 1 mm upwards, enables a quick and secure, backlash-free one- or two-sided engagement of shafts without the need for working space or additional tools (like a screwdriver). If requested, torque limited coupling (in one or both rotation directions) is possible. The production methods comprise a variety of materials and manufacturing processes. ...
Weiterlesen … Scalable coupling part machined from one workpiece
Sensor for the Carrier-envelope Phase of Short Laser Pulses: A Measuring Device and a Laser Control Device
Ref.-Nr.: 1202-4253-WT
Sensoren, Geräte und Komponenten

We present a sensor for the carrier-envelope phase of a few-cycle femtosecond laser. The sensor uses the electron current emitted from a nanoscale metal tip onto which we focus high-repetition-rate laser pulses.
Possible applications of this sensor are in the field of the technique of controlling and using pulse lasers, in particular used for measuring or high-power irradiation purposes.
The size of such a simple stand-alone sensor device for the carrier-envelope phase could be in ...
SIMNRA 7 software
Ref.-Nr.: 1801-4849-WT
IT / Software / Bioinformatik
SIMNRA is a Microsoft Windows program for the simulation of energy spectra for ion beam analysis with incident ions from about 100 keV to many MeV. SIMNRA can be used for the simulation of Rutherford backscattering (RBS), elastic backscattering with non-Rutherford cross-sections (EBS), nuclear reaction analysis (NRA), elastic recoil detection analysis (ERDA), and medium energy ion scattering (MEIS). Almost 3000 different non-Rutherford and nuclear reactions cross-sections for incident protons, ...
Simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples
Ref.-Nr.: 0105-5434-IKF
Analytik
A simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples, with various applications such as enzymatic assays, clinicals tests, and as point of care tests in the field of ageing.
Simultaneous multi-color fluorescence microscopy with improved spatio-temporal resolution and image contrast
Ref.-Nr.: 0707-5644-BC
Bildgebung und Mikroskopie

Fluorescence microscopy is one of the key techniques in the life and materials sciences, with applications ranging from routine diagnostics to state-of-the-art research investigations. Key to this success has been its intrinsic advantages combined with continuous improvement in its fundamental features such as resolution, speed, and sensitivity.
Two key challenges are fast single-fluorophore imaging of multi-color samples. This need arises in a broad range of settings such as very high-resolution ...
Single Photon Detection: Advanced DePFET with High Amplification
Ref.-Nr.: 1201-5766-BC
Sensoren, Geräte und Komponenten

The invention relates to a new and improved concept for Depleted p-channel Field Effect Transistors (DePFET) detectors that provides a significantly higher intrinsic amplification. By the extension of the transistor layout, former limitations were overcome.
DePFETs are insufficient for many applications in terms of the achievable intrinsic amplification. This is since shorter transistor channels needed for high amplification would increase the detector noise caused by impact ionization events.
Additional ...
Weiterlesen … Single Photon Detection: Advanced DePFET with High Amplification
SNOM: New Sensitive Detection Method for Small Periodic Signals
Ref.-Nr.: 0302-6225-BC
Sensoren, Geräte und Komponenten

The invention relates to a new detection method for small periodic signals in Scanning Near Field Optical Microscopy (s-SNOM). Solving the problem of the rapid sampling rates necessary for lock-in amplification, the method is a powerful new readout system for various other applications as well.
Lock-in detection is a widespread technique, which enables the detection of very small periodic signals. However, it imposes constraints between the lock-in modulation frequency and the sampling ...
Weiterlesen … SNOM: New Sensitive Detection Method for Small Periodic Signals
Soft Capsule Endoscope - "B-MASCE"
Ref.-Nr.: 0104-5410-BC
Sensoren, Geräte und Komponenten

Im Zuge der stetigen Weiterentwicklung und Nachfrage auf dem Gebiet der minimal invasiven Chirugie wurde am Max-Planck-Institut für intelligente Systeme in Stuttgart im Team von Herrn Prof Sitti für patientenfreundliche Magen-Darm-Untersuchungen ein kabelloses kapselförmiges Endoskop in Pillengröße, das sogenannte "B-MASCE" entwickelt. Die aus einem Elastomer bestehende Kapsel dient hierbei sowohl als Gehäuse als auch als Federelement für die Nadel. Über in der Kapsel eingebaute Magnete ...
Stable, site-specific conjugation of His-tagged proteins via cobalt (III) carbonate reagents
Ref.-Nr.: 0105-5774-IKF
Analytik
Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

This invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier.
Substituted Imidazolium Sulfuranes and their use as novel Electrophilic Group-Transfer Reagents
Ref.-Nr.: 0042-5063-LC
Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

The ability of hypervalent iodine compounds to act as electrophilic group-transfer reagents has been extensively exploited during the last several years in a variety of synthetically useful transformations
like cyanations and alkynylations. Now it was found, that novel imidazolium sulfuranes, which are isolobal to I(III) species and also depict the key threecenter four-electron bond motive, can be used as an alternative platform for the development of new electrophilic group-transfer reagents.
Imidazolium ...
SUMOvera: A Truly Orthogonal Cleavage Module
Ref.-Nr.: 0402-5439-LI
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.
Superamphiphobic membranes for gas exchange and scrubbing
Ref.-Nr.: 0903-4616-LC
Neue Materialien

Novel gas exchange membranes based on superamphiphobic coatings applied on metal meshes were created and tested in different applications, like gas scrubbing and blood oxygenation.
By using the novel membrans drawbacks of traditional membranes - like insufficient wetting, plugging and depositions chemical incompatibility and temperature instability - can be avoided.
Weiterlesen … Superamphiphobic membranes for gas exchange and scrubbing
Sustainable High-Performance Energy Storage: The Solar Battery
Ref.-Nr.: 0104-5740-BC
Neue Materialien

The invention relates to a new solar battery half-cell that can be recharged by natural resources like sunlight. Remarkable sustainability is provided by the possibility to use sunlight as a source of primary energy and by solving the problem of low capacity of state-of-the-art battery technologies.
Sustainable solutions for efficient storage of electrical energy are of great importance for the global energy transition and other applications. Typical batteries, however, are often charged ...
Weiterlesen … Sustainable High-Performance Energy Storage: The Solar Battery
Tet-inducible “gePSI” protein reversibly regulates eukaryotic ribosomal protein synthesis in a cell-type specific manner allowing to impose and release protein synthesis inhibition in a select subset of cells in mixtures
Ref.-Nr.: 0602-5504-LI
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)
Proteins are the main functional units within cells. Their regulated synthesis and degradation are crucial for controlling biological processes. In all cells, protein synthesis is used to respond to extra- and/or intracellular cues to remodel cellular function. Previous studies probing the role of protein synthesis have used chemical inhibitors, often common antibiotics, which are effective but lack functional and cell-type specificity when applied to a mixture of cells.
The Camera Offset Space: Real-time Potentially Visible Set Computations for Streaming Rendering
Ref.-Nr.: 1200-5472-BC
IT / Software / Bioinformatik

The presented technology offers an enhanced streaming rendering pipeline that enables the display of high fidelity, high framerate and high solution for noval views in real time on thin lightweight HMDs suitable especially for VR experiences.
How does it work?
The key idea of this technology is based on a novel algorithm for Potentially Visible Set (PVS) creation: the camera offset space (COS), which for a given point on the image plane provides information under which camera ...
Touchless Positioning Interface: The Precise Nanosheet Moisture Sensor
Ref.-Nr.: 1201-4882-BC
Sensoren, Geräte und Komponenten : Sensoren

The invention relates to a new precise sensing device for gas and vapor that is based on a 2D nanosheet material. A remarkably high sensitivity allows for the application in smart touchless interfaces to operate future digital devices.
Sensors for environmental changes are one of the most promising approaches for touchless interface devices but state-of-the-art technologies are not satisfactory. They typically exhibit too long response times.
With its capability to resolve sub-centimeter ...
Weiterlesen … Touchless Positioning Interface: The Precise Nanosheet Moisture Sensor
Towards New Optical Devices: The Electrically-Controlled Dynamic Metasurface
Ref.-Nr.: 1201-5777-BC
Photonics

The invention relates to a new dynamic optical component based on a metasurface that can be operated electrically at visible frequencies. Realizing pixel level addressability of the metasurface properties paves the way towards the next generation of optical devices for data storage and communication.
Nanoantennas on a metasurface are used to directly change properties of light but are typically limited to static effects. However, state-of-the-art devices with optical reconfigurability are ...
Weiterlesen … Towards New Optical Devices: The Electrically-Controlled Dynamic Metasurface
Ultracompact medical ventilation system
Ref.-Nr.: 0901-6012-WT
Medizin
Sensoren, Geräte und Komponenten

The invention relates to a new, ultracompact non-invasive medical ventilation system. The BIPAP (Biphasic Positive Airway Pressure) ventilation unit, of size and weight of a tennis ball, is easy to handle and allows low-budget mass production. It can be powered by a rechargeable battery-pack – a great advantage in case of mobile use or damaged/unstable infrastructure leading to frequent blackouts. These benefits, ...
Ultrafast Charging-Discharging of Nano-sized Na₃V₂(PO₄)₃ Embedded in Porous Carbon Matrix for Sodium Ion Batteries
Ref.-Nr.: 1201-4746-LC
Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

We offer the new composite nanomaterial for sodium ion battery cathodes. These carbon-coated nanosized Na3V2(PO4)3 particles embedded in a highly effective mixed conducting porous carbon matrix can be easily prepared by means of facile soft-chemistry based preparation method with a post heat treatment procedure. The resulting cathodes can be charged and discharged in 6 s with high current density of 22 A/g, deliver the specific capacity of 44 mAh/g and ...
Ultrarapid cryo-fixation during live observation on a fluorescence microscope
Ref.-Nr.: 0803-6035-IKF
Bildgebung und Mikroskopie

A ultrarapid cryo-arrest directly on a multimodal fluorescence microscope that preserves molecular activity patterns during observation of their dynamics in living cells at any timepoint.
Weiterlesen … Ultrarapid cryo-fixation during live observation on a fluorescence microscope
Uniform Deposition of Large-Area Multicomponent Coatings using Laser Irradiation Scanning of Predesigned Targets
Ref.-Nr.: 1201-4172-BC
Sensoren, Geräte und Komponenten

Pulsed laser deposition (PLD) facilitates efficient production of thin films using a laser ablation technique. Targets are selected according to the coating desired. Multiple targets are either moved mechanically to the incidence area, or they are fixed so that the laser beam is alternatively focused on each of them. Multiple targets are, however, known to cause discontinuities, whereas single multicomponent target usually doesn’t ensure compositional homogeneity. The technology presented here ...
Unique multifunctional oligonucleotide enabling ultrafast RNA-protein interactions in cells and other uses thereof
Ref.-Nr.: 0214-5029-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Unique multifunctional oligonucleotide for the ultrafast transcriptome-wide identification of RNA-binding protein (RBP) targets.
Water content sensor for biological soil crusts
Ref.-No.: 0901-4720-WT
Sensoren, Geräte und Komponenten

In arid and semiarid regions biological soil crusts (BSC) cover about 1/3 of the soil surface. As far as it is known, these BSC (consisting of cyanobacteria, algae, fungi, bryophytes, and other bacteria living in contact with soil particles) are crucial for the global terrestrial carbon and nitrogen cycle. The water status plays a major role, since their water content directly controls the activity of these poikilohydric organisms.
Weiterlesen … Water content sensor for biological soil crusts
Xenorhodopsin - a new inward-directed proton pump for an alternative optogentic approach
Ref.-Nr.: 0601-5295-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues, and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...