Technologieangebote

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Analytik

IT / Software / Bioinformatik

Prozesse und Methoden (inkl. Screening)

Medizin

Forschungs-Reagenzien

Nukleinsäure-, Protein-, Zell-bezogene Technologien

Grüne Biotechnologie

Bildgebung und Mikroskopie

Neue Materialien

Sensoren, Geräte und Komponenten

Photonics

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Treffer

(Differential) Refractive Index Measurement with low Uncertainties and Dimensions using an Asymmetric Nanofluidic Grating Detector

Ref.-Nr.: 0707-5502-BC

Sensoren, Geräte und Komponenten

The invention relates to a new method for measuring the refractive index n of a substance with low uncertainties. The latter is in particular the case when the deviation of the refractive indices Δn, as compared to another substance, is only small (Δn < 0.02). Thereby, sensitive and contactless information on molecule concentration or process conditions for a wide range of applications can be obtained. The low uncertainties are enabled through the development of an asymmetric nanofluidic ...

A genetically conserved and transferable defense mechanism protects plants from herbivores

Ref.-Nr.: 1602-6322-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Grüne Biotechnologie

Our scientists have identified a conserved defense mechanism covering a new metabolite in tobacco that protects against leafhoppers. They have discovered how to reconstitute it in vitro and engineer the compound in crop plants, demonstrating that it confers resistance to herbivores.

A graphene diode with bias-induced barrier modulation

Ref.-Nr.: 1201-5155-BC

Sensoren, Geräte und Komponenten

Metal-insulator-metal (MIM) diodes are very promising for application as rectennas for solar energy harvesting, photo-detectors and high frequency mixers. Good MIM diode performance requires a high asymmetry, a strong nonlinearity, a large responsively, as well as a low resistance or a high on-current. These figures of merit are mainly determined by the work function difference of the electrodes, and the barrier height between the insulator and the electrode materials. In the design of MIM diodes, ...

A high-throughput compatible workflow for generation and analysis of homogenous human neural microtissues

Ref.-Nr.: 1012-5677-LI

Prozesse und Methoden (inkl. Screening)

File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)

A robust method for producing and analyzing highly homogenous human neural organoids.

A method and device for reversibly attaching a phase changing metal to an object

Ref.-Nr.: 0104-5132-BC

Sensoren, Geräte und Komponenten

Reversible adhesion can be used to transfer or to manipulate objects. Especially if the objects are small and/or fragile their manipulation become very challenging. Intermolecular forces such as Van-der-Waals can be used to achieve a strong adhesion between the objects. Moreover, surface functionalization and the creation of nano- and microstructures can be used to improve these adhesion properties. Unfortunately, the adhesion becomes insufficient if the surfaces are wet or rough. Another problems ...

A method for the production of plants with altered photorespiration and improved CO2 fixation

Ref.-Nr.: 0706-5666-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Grüne Biotechnologie

Recently, many efforts have been made to improve growth and yield of crop plants. CO2 fixation in plants is primarily catalyzed by the enzyme ribulose-1,5-bisphosphate carboxylase (Rubisco). The inherent inefficiency of Rubisco necessitates an additional metabolic process termed photorespiration, which results in the loss of carbon and energy. In fact, it has been estimated that plants lose approximately 25% of the fixed carbon due to photorespiration. Despite several attempts to improve ...

A MONTE-CARLO CODE FOR CALCULATING COLLISION PHENOMENA IN RANDOMIZED TARGETS

Ref.-Nr.: 1801-6323-WT

IT / Software / Bioinformatik

The invention relates to a Monte-Carlo program implemented in Fortran 90. It treats the bombardment of incident ions on different target structures such as mono-atomic targets, layer structures or composition target structures. The two general cases considered in the code are the static case, where the target composition is fixed during the simulation, and the dynamic case, where modifications of the target caused by the ion bombardment are taken into account. Prospectively, further developments ...

A novel biomarker for a reliable diagnosis of colorectal cancer based on differentially methylated genomic regions

Ref.-Nr.: 0301-4550-LI

Medizin : Diagnostika

With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...

A novel class of herbal compounds saiginols with strong UV-B absorbing properties

Ref.-Nr.: 0402-4816-MG

Grüne Biotechnologie

UV-B radiation is a major damaging agent causing damage to plants, tissues and human or animal skin upon exposure. To persist strong UV-B radiation plants produce additional antioxidant sunscreen pigments that belong to the chemical compound family of phenylpropanoids. Since many conventional compounds with sunscreen protection potential do not enter the market due to toxic side effects or they bear the risk to become environmental pollutants when accumulating in natural resources, application ...

A novel inhibitor targeting matrix accumulation in cancer

Ref.-Nr.: 0105-5855_1-IKF

Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Cancer remains a major health burden and is the second leading cause of death globally (WHO). The microenvironment of cancer cells plays an important role in disease progression. In particular, the composition of the extracellular matrix regulates angiogenesis, cell proliferation, differentiation, cell survival and apoptosis. Dysregulation and accumulation of the extracellular matrix promotes cellular transformation and metastasis leading to cancer progression. A better understanding of the role ...

A process for recycling of noble metals

Ref.-Nr.: 0041-5034-WT

Prozesse und Methoden (inkl. Screening)

Noble metals are used in various fields of application such as catalysis, jewelry, high technology electronic equipment, equipment for glass industry and many others. As noble metals are rare and hard to extract from the ores or exhausted compounds, many efforts have been undertaken to establish an efficient recycling process. Due to their corrosion resistant properties, noble metals recycling by means of dissolution is limited to the usage of very reactive and harmful chemicals such as Aqua Regia. ...

A system-wide approach for the identification of druggable proteins in a complex mixture

Ref.-Nr.: 0402-5163-MG

Analytik

In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...

A tunable cohesive granular material

Ref.-Nr.: 0705-5158-BC

Neue Materialien

For sieving and separation purposes porous materials with adjustable sizes and shapes of the pores as well as tunable mechanical properties are required. The existing materials such as sintered materials, open-cell foams or cemented aggregates can be made porous but they are either fragile or can collapse for large deformation. Therefore, chemically inert and damage resistant porous materials with adjustable permeability as well as mechanical and geometrical properties that can sustain large deformation ...

Accurate contactless measurement of surface and micro sample temperatures

Ref.-Nr.: 0041-5601-WT

Sensoren, Geräte und Komponenten

The study of mechanical properties of materials at high temperatures at the microstructural length scale requires dedicated testing setups. An accurate measurement of the sample temperature is vital for reliable testing. Most of the successful current testing platforms record the temperatures of the sample and tip near the heating sources but not at the respective surface. As a consequence, due to spatial and temporal thermal gradients a reliable surface temperature cannot be measured today. Even ...

Advanced collector sweeping with homogenous power deposition of the electron beam in high-power rf vacuum-tubes

Ref.-Nr.: 1801-3749-WT

Sensoren, Geräte und Komponenten

This invention includes two alternative advanced methods to achieve a homogenous collector power distribution, which improves the collector capability of high power vacuum-tubes by a factor of two as compared to conventional methods. Furthermore the applied method has a high flexibility to vary the power distribution over a wide range of profiles and match the deposition profiles to different designs of collectors in existing or future electron tubes.

Advanced magnetic zipper for industrial and consumer applications

Ref.-Nr.: 0705-4974-BC

Sensoren, Geräte und Komponenten

Conventional mechanical zippers find manifold applications for luggage, clothing or even industrial applications. However, their design features significant disadvantages. In particular, they require the use of both hands by the user to align the ends of the garment and lock the insertion pin into the slider. This mechanism can be prone to jamming and failure and more generally requires the user to free his or her hands. The user must further use one or both hands to move the slider along the ...

Advanced vorticity measurements on complex flows

Ref.-Nr.: 0705-4770-BC

Sensoren, Geräte und Komponenten

The dynamics of complex flows and turbulences are dominated by vortices of many different scales. In general, the vortex describes the group motion of fluid elements in a circular fashion, whereas the vorticity quantizes this spinning moment of a fluid element confined to a small neighborhood.

For diagnosis of flows, conventional techniques track the movements of small particles added into the flow (e.g., Lagrangian particle tracking, LPT, and particle image velocimetry, PIV). However, ...

Air-stable binary Ni(0)–olefin (pre)catalyst

Ref.-Nr.: 0042-5881-LC

Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

A family of 16-electron binary Ni(0)-stilbene complexes Ni(Rstb)3 as a new class of air-stable Ni(0) (pre)catalysts was developed.

All-in-one nanoprinting approach for the synthesis of unclonable anti-counterfeiting nanofilms

Ref.-Nr.: 0401-6646-MG

Prozesse und Methoden (inkl. Screening) : Produktion

In addition to causing trillion-dollar economic losses every year, counterfeiting threatens human health, social equity and national security. Current materials for anti-counterfeiting labelling typically contain toxic inorganic quantum dots and the techniques to produce unclonable patterns require tedious fabrication or complex readout methods. Carbon dots (CDs) stand out because of their stability, low toxicity, widely available precursors and bio-/ecofriendly preparation. However, most reported ...

Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia

Ref.-Nr.: 0305-3252-LI

Medizin : Therapeutika

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...

Anti-mouse and anti-rabbit IgG secondary VHH single domain antibodies optimized for all immuno-labeling applications

Ref.-Nr.: 0707-5419-LI

Neue Materialien

Anti-IgG secondary antibodies are major tools for the detection or immobilization of primary antibodies in approaches such as western blotting, ELISA, Co-IP and immunofluorescence. Polyclonal anti-IgG secondary antibodies are produced in animals, such as mouse, rabbit, rat, and goat and are directed against the IgG classes of these animals. Thus, the generation of such secondary antibodies requires the keeping and use of a large number of animals, which is not only costly but also a major ethical ...

Apparatus and method for creating a holographic ultrasound field in an object

Ref.-Nr.: 0104-5066-BC

Sensoren, Geräte und Komponenten

Ultrasound is being used in many fields ranging from medical imaging and therapy to non-destructive testing, contact-free particle handling or spatially selective heating in industrial settings. Often, those applications require shaping (including focusing) of an ultrasonic field. Compared to existing transducers with fixed lenses or phased array transducers (PATs) the present invention allows much more sophisticated sound fields to be generated using much simpler and cheaper technology.

Apparatus for Generating Random Numbers using an Optical Parametric Oscillator

Ref.-Nr.: 1201-5494-BC

Sensoren, Geräte und Komponenten
Photonics

The invention relates to an apparatus for generating random numbers, using an optical parametric oscillator.

The generation of random numbers is important in information science as well as in modelling and simulation. In cryptography, for instance, random numbers are needed for encryption algorithms. Preferably, the generated numbers are true (i.e. non-predictable) and have an equal distribution.

The apparatus according to the invention is based on the bi-stable outcome of an optical ...

Application of novel channelrhodopsins: molecular engineering, site-specific opsin targeting, discovery of new variants and the advancement in optogenetic devise development

Ref.-Nr.: 0601-4259-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...

Automated real time determination of crystal size and 3D shape distribution to quantify and predict the properties and dynamics of the crystallization processes

Ref.-Nr.: 1402-5690-LC

Analytik
Prozesse und Methoden (inkl. Screening)

To monitor crystallization processes a special camera setup to measure the crystal size and 3D shape distribution was developed.
The setup consists of two high-speed cameras that are positioned orthogonally to one another such that a precise overlap of both fields of view can be achieved. The setup further contains a specially designed flow-through cell that allows to observe the crystal suspension from both camera directions and given the opportunity to temperate the solution within the cell. ...

Bildleiter

Ref.-Nr.: 1801-6386-WT

Sensoren, Geräte und Komponenten

Die Erfindung betrifft einen Bildleiter, der insbesondere für den Einsatz in einer Umgebung mit radioaktiver Strahlung geeignet ist. In einer solchen Umgebung verringert sich die Transmission des Bildleiters mit der Zeit. Bekannterweise kann die Transmission des Bildleiters durch Erwärmen auf eine Temperatur im Bereich von 100° bis 300° regeneriert werden. Weil dieses Erwärmen bisher in einem Ofen erfolgte, implizierte das Regenerieren des Bildleiters seinen Abbau von seinem Betriebsort, ...

Bioinspired Liquid-Superrepellent Fibrillar Dry Adhesives

Ref.-Nr.: 0104-5929-GÖ

Neue Materialien

Since 2000 bioinspired fibrillar dry adhesives have been studied intensively culminating in commercial products already available on the market. Currently known fibrillar adhesives are fully wetted by oils, leading to significantly decreased adhesion and friction performance. Therefore, a high demand exists for reversible dry fibrillar adhesives that can repel oil-like liquids and adhere strongly to surfaces wetted by them.

To meet the aforementioned challenges, an extraordinary fibrillar ...

BiQ Analyzer Software for DNA Methylation Analysis, Visualization and Quality Control

Ref.-Nr.: 1200-3727 GÖ

Analytik

BiQ Analyzer is a software tool for easy visualization and quality control of DNA methylation data. With more than a thousand users worldwide, BiQ Analyzer has become a standard tool for processing DNA methylation data from bisulfite sequencing. BiQ Analyzer has been selected by ABI to be part of the Applied Biosystems Software Community Program.

BLE-based micro-transmitter and monitoring app

Ref.-Nr.: 0707-5558-MG

Sensoren, Geräte und Komponenten : Geräte

A lightweighted,  long-life, long-range and low-cost Bluetooth Low Energy (BLE)-based tracking system with monitoring app.

Bottom-up assembly of synthetic extracellular vesicles for biomedical applications

Ref.-Nr.: 0105-5888-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Prozesse und Methoden (inkl. Screening) : Produktion
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Natural extracellular vesicles (EVs) are lipid vesicles that carry a plethora of biologically active molecules including soluble and membrane proteins, nucleic acids and metabolites. They have recently been recognized as a promising cell-free alternative to cell transplantation or as a novel therapeutic tool in various diseases. Many in vitro and in vivo studies have shown beneficial effects of EVs from different cell types in diseases ranging from cardiovascular conditions to ...

Broad-spectrum vector-based antiviral and potential live vaccine

Ref.-Nr.: 1402-5459-LC

Medizin
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Our scientists developed a vector-based high tolerable and efficient antiviral (plasmid-derived defective interfering particles) to support IAV pandemic preparedness. The DIP also shows a broad-spectrum antiviral activity against other respiratory viruses, e.g. RSV and SARS-CoV-2 and is Intended for intranasal administration (droplet spray) for human use. A state-of-the-art, high-yield production process in a GMP-ready controlled and sterile environment in animal cell culture.

Carbon-neutral and carbon-positive photorespiration bypass routes supporting higher photosynthetic rate and yield

Ref.-Nr. 0402-5003-MG

Grüne Biotechnologie

Carbon fixation is arguably the most important biochemical processes on earth, supporting our biosphere by transforming inorganic carbon into organic matter and literally feeding all life forms. The reductive pentose phosphate cycle (rPP, also known as the Calvin–Benson–Bassham Cycle) is responsible for ≥95% of the carbon fixed in the biosphere. Although under a strong selective pressure for eons, this process displays major inefficiencies, some are due to the low catalytic rate and the ...

CellNetAnalyzer: A Software Package for Analyzing Structure and Function of Cellular Networks

Ref.-Nr. 1402-3895-LC

IT / Software / Bioinformatik

CellNetAnalyzer (CNA) is a MATLAB toolbox providing various computational methods for analyzing structure and function of metabolic, signaling, and regulatory networks. For metabolic networks, CNA supports a variety of stoichiometric and constraint-based modeling techniques, including flux balance analysis (FBA), metabolic flux analysis, elementary-modes analysis, or computational strain design (e.g., minimal cut set analysis). Signal transduction and (gene) regulatory networks can be ...

Chlamydomonas algae strains for molecular farming

Ref.-Nr.: 0402-3923-MG

Grüne Biotechnologie

The unicellular green alga Chlamydomonas reinhardtii is both an invaluable model organism for plant biology and an attractive biotechnological production system for biofuels and biopharmaceuticals. Despite the availability of efficient methods for introduction of foreign genes into the nuclear genome of the alga, transgene expression levels are usually very poor. This is a serious limitation that has severely hampered both post-genomics research in Chlamydomonas and use of the ...

Closure Device for Evaporator Cell of a Coating System

Ref.-Nr.: 1201-5136-BC

Sensoren, Geräte und Komponenten

Evaporation cells for thin film deposition often operate under ultrahigh vacuum or special gas atmosphere, requiring long growth campaigns and short maintenance openings to preserve the best possible vacuum environment. The deposition leads to coating of the inner chamber walls, the removal of which is difficult and very time consuming. Growth control and interruptions during material deposition may require frequent operation of the closure device or shutter. The commonly used shutter (Fig. 1) ...

Compact high-voltage vacuum feedthrough

Ref.-Nr.: 0302-4988-WT

Sensoren, Geräte und Komponenten

Applying high voltages in vacuum applications requires feedthroughs, which electrically insulate the conductor from the vacuum chamber whilst being vacuum-tight. In high- and ultrahigh vacuum environments, the materials used need to be low in outgassing rates. The current technology for feedthroughs withstanding tens to hundreds of kilovolts relies on vacuum-tight ceramic to metal connections, which are heavy, fragile and prone to contamination. Commercially available feedthroughs are stand-alone ...

Compounds modulating frameshifting efficiency for antiviral therapy against HIV-1, SARS-CoV-2 and alphaviruses

Ref.-Nr.: 0707-5639-MG

Medizin : Therapeutika
Medizin : Vakzine

Many viruses use programmed ribosome frameshifting (FS) to increase genome-coding capacity and to regulate the stoichiometric ratio between viral proteins. Among them are human-pathogenic viruses HIV-1, SARS-CoV-2 and alphaviruses such as Semliki Forest virus (SFV). Synthesis of two major HIV-1 genes, gag and pol, requires –1FS. The ratio between Gag and Gag-Pol is crucial for virus propagation and its dysregulation is detrimental for replication, particle formation and infectivity of HIV-1. ...

Core-shell catalyst design for improved heat management with highly exothermic reactions

Ref.-Nr.: 1402-5768-LC

Prozesse und Methoden (inkl. Screening)
Neue Materialien

Prof. Kai Sundmacher and co-workers at the MPI for Dynamics of Complex Technical Systems developed a novel core-shell catalyst design with a highly active catalyst core surrounded by an inert, low-permeability shell. The new catalyst design leads to an intrinsic heat management that avoids hotspots in strongly exothermic reactions. This allows faster reactor start-up and shut-down and makes the catalysts suitable for rapid load changes in discontinuous processes.

Cryo-Light Microscope and Immersion Medium for Cryo-Light Microscopy

Ref.-Nr.: 0707-5496-BC

Bildgebung und Mikroskopie

Cryogenic fluorescent light microscopy of flash-frozen cells presents significant advantages and provides an important complement to electron cryo-microscopy. In particular, bleaching decreases drastically at low temperature while the fluorescence yield of many fluorophores increases and the spectral bands narrow. The application of modern super-resolution methods such as STED, PALM, STORM, or SIM at cryogenic temperature holds the prospect of imaging fluorescent proteins with high precision in ...

Cyclopropenylylidene-Stabilized Phosphenium Cations and their Applications in Homogeneous Catalysis

Ref.-Nr.: 0042-5177-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

We offer novel phosphenium ligands and corresponding metal complexes (both air stable) that are claimed as substances by granted EP and US patents. The ligands can be prepared in multigram scale by simple direct condensation. The corresponding gold complexes are suitable as homogeneous catalysts in organic synthesis (such as cycloisomerization) that can be easily precipitated and recycled due to their salt properties.

DECONV-Software

Ref.-Nr.: 1401-4358-WT

IT / Software / Bioinformatik

Das Verfahren der Lock-in-Thermographie (LIT) gestattet es, 2-dimensionale Bilder der Verteilung der in einer Probe dissipierten Leistung zu erzeugen. Allerdings sind diese Lock-in Thermogramme noch durch die unvermeidliche laterale Wärmediffusion in der Probe "verbreitert" (blurred). Das "DECONV"-Programm gestattet es, diese thermische Verbreiterung durch die Anwendung eines örtlichen Entfaltungs-Verfahrens wieder rückgängig zu machen und dadurch die effektive Ortsauflösung der Lock-in-Thermographie ...

Digital scanner

Ref.-Nr.: 0105-5505-BC

Bildgebung und Mikroskopie

Light microscopy enables fascinating insights into the microcosm of life. It is one of the key techniques in life science and provides access to a better understanding of biology across many orders of magnitude in time and space. The use of visible light allows for minimally invasive imaging - even of living cells - and direct observation with the human eye. However, the use of visible light limits the resolution of the image obtained to about half the wavelength of the used light. The limiting ...

DISPLAY IN CONDITIONS OF BRIGHT AMBIENT LIGHT

Ref.-Nr.: 1305-5612-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Dual Inhibition of plexin-B1 and plexin-B2

Ref.-Nr.: 0603-5770-IKF

Medizin : Therapeutika

A novel molecular target of the semaphorin-plexin system to develop treatment options for cancer and for osteoporosis.

Dynamic control of three-dimensional light distributions through wavefront engineering: hardware and software system

Ref.-Nr.: 0202-5001-LI

Analytik
IT / Software / Bioinformatik

Engineering light distributions in a three-dimensional volume to achieve selective illumination profiles is an instrumental task shared by many optical and microscopy techniques. The optimization of the light distribution can lead to significant enhancement of relevant performance figures and ultimately to the extension of the instrument or experimental protocol capabilities1,2,3,4,5. Targeted illumination profiles can be used either to mechanically interact with molecules at nanometer ...

Dynamic Parallel Imaging: New Method for Accelerated MR Imaging

Ref.-Nr.: 0107-5654-BC

Bildgebung und Mikroskopie

The invention relates to a new method to reduce acquisition time in MR imaging. It is based on the variation of the sensitivity profile of the RF coils and allows an easy access to an additional source of spatial information to further improve imaging.
MR imaging is among the most important tools for modern medical diagnostics with a unique range of applications. The imaging duration however limits the applicability for situations with movements within the volume of interest. Therefore, many ...

eeFILM – Extended Excitation for Faster Measurement of Fluorescent Lifetimes

Ref.-Nr.: 0707-5026-BC

Sensoren, Geräte und Komponenten

The estimation of excitation lifetimes based on fluorescence or phosphorescence emission is an essential technique in basic and applied science. It provides information on molecular interactions
as well as on physical properties. Measuring the emission lifetime with spatial resolution provides an imaging modality, which in case of fluorescence is called Fluorescence Lifetime Imaging (FLIM). FLIM is applied extensively in biological imaging in order to determine the conformation, activation, ...

Efficient Optical Readout: Highly Versatile Chemical Sensor

Ref.-Nr.: 0104-6343-BC

Sensoren, Geräte und Komponenten

The invention relates to an innovative detector concept for the identification of analytes in a gas that is extremely versatile and yet easy to construct and to operate. The superior properties were reached by an optical readout system for electrical signal of multiple detector cells.

Detecting and quantifying concentrations of analytes of interest is usually achieved using materials that change their electrical properties upon exposure. As different materials combined in one sensor need ...

Electroluminescence Imaging Evaluation: Software EL-Fit

Ref.-Nr.: 1401-4175-WT

IT / Software / Bioinformatik

This software is based on the paper "Quantitative evaluation of electroluminescence images of solar cells" by O. Breitenstein et al.1). It allows to load a number of electroluminescence (EL) images to different biases, which have to be given as ASCii tables.

Electron Microscopy: Ready to Use AI for Focus and Astigmatism Adjustment

Ref.-Nr.: 0202-6337-BC

Bildgebung und Mikroskopie

The invention relates to a new method for imaging setting optimization for electron microscopy
based on deep learning. The AI is a robust and simple to implement optimization possibility for
direct operation with various types of electron microscopes.

For a wide spectrum of applications automated precision electron microscopy is a powerful
method. Existing auto focusing routines are often based on physical models of the microscope
and are hence lacking general applicability ...

Enhancement resonator including non-spherical mirrors

Ref.-Nr.: 1202-4590-WT

Sensoren, Geräte und Komponenten

An Enhancement Cavity (EC) with at least one toroidal and/or cylindrical mirror is described. This allows for an arbitrary beam ellipticity of the eigenmode. In particular at a stability edge, where the ellipticity diverges with purely spherical optics, a round beam can be obtained.

Environmental Monitoring: Detection of Atmospheric Particulate Matter PM2.5

Ref.-Nr.: 1629-5711-WT

Sensoren, Geräte und Komponenten

The invention relates to a new and durable system, which brings the possibility of accurate size measuring and simultaneous counting of airborne particles with an aerodynamic diameter of up to 2.5 microns.

Measuring the particulate matter contamination in a gas in the range of PM2.5 is advantageous or crucial for various applications. Monitoring the concentration of the corresponding particles, for example in air, reveals information about pollution. The possibility of aerosol ...

Exergy Efficient Chlorine Separation

Ref.-Nr.: 1402-5465-LC

Prozesse und Methoden (inkl. Screening) : Chemische

Three novel processes to separate Cl2 from unconverted HCl in the anode outlet stream of a electrochemical gas-phase reactor were developed at the MPI for Dynamics of Complex Technical Systems. The novel processes lead to a higher reaction yield in gas-phase reactor and have an reduced energy demand compared to the Bayer UhDenora state-of-the-art process.

Extraction of nanocellulose from cellulose pulp in reactive eutectic media

Ref.-Nr.: 0401-5970-LC

Prozesse und Methoden (inkl. Screening)
Neue Materialien

A novel green chemistry process to prepare nanocellulose in efficient, safe and sustainable manner based on the use of eutectic, highly concentrated ionic media is offered.

f-Chrimson and vf-Chrimson, two ultrafast variants of the red-light activated channelrhodopsin Chrimson

Ref.-Nr.: 0601-5208-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues, and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...

Fabrication of fluid filled metal microarchitectures

Ref.-Nr.: 0041-6492-WT

Prozesse und Methoden (inkl. Screening)
Neue Materialien

LEL technology stands out for its precision in fabricating 3D metal microarchitectures with intricate geometries and the ability to seamlessly integrate liquids. It utilizes a voxel-by-voxel deposition method, which allows for the creation of complex shapes with submicron resolution. The process involves optimizing variables like deposition voltage, air pressure, and orifice diameter. A significant advantage of LEL is its capacity to alter the pH and composition of the supporting electrolyte solution, ...

Fabrication of ultrathin nano-porous membranes and semiconductor nanowires

Ref-Nr.: 0104-4458-GÖ

Bildgebung und Mikroskopie
Neue Materialien

Semiconductor nanowires are of vital importance for many applications, such as flexible electronics, photonics, sensors, and energy harvesting and storage devices. As standard fabrication procedure, vapor-liquid-solid (VLS) growth employs metal catalyst particles (such as gold) as seeds for growth of nanowires. The seeds are deposited on a solid substrate, melted by heating and then exposed to a gas atmosphere containing source materials of the semiconductor. When the metal droplets are supersaturated, ...

Fast and efficient protein purification form prokaryotic and eukaryotic hosts

Ref.-Nr.: 0109-4896-LI

Prozesse und Methoden (inkl. Screening)

Fusion Tags Comprising Ubiquitin-like Modifiers and Corresponding Proteases For Protein Purification From Selected Eukaryotic Expression Hosts

Fast Photodetector with Intrinsic Amplification: Avalanche Photodiode Array

Ref.-Nr.: 1201-5750-BC

Sensoren, Geräte und Komponenten

The invention relates to a new monolithic Avalanche Photodiode array with a novel inter pixel isolation structure. The technology allows the design of sensitive photodetectors with remarkable spatial resolution at very fast imaging capabilities for various applications.
Although Avalanche Photodiodes are a convenient tool due to their intrinsic amplification, their use in photodetectors with high pixel densities is challenging due to insufficient isolation of the pixels. Hence their use in ...

Faster Processing: Neural Network for MR Imaging Parameter Prediction

Ref.-Nr.: 0107-6054-BC

Bildgebung und Mikroskopie

The invention relates to a new method for processing magnetic resonance (MR) data based on a neural network (NN). After training, the NN quickly delivers high quality CEST images with low computational effort. Additionally, it provides uncertainty data aiding to judge the images appropriately.

Typically, sophisticated MR contrasts are calculated based on complex mathematical models, which is computationally expensive, and it requires long processing durations. Besides that, the results ...

FFA2 (GPR43) and FFA3 (GPR41) as novel targets for antidiabetic therapies

Ref.-Nr.: 0603-4987-IKF

Medizin : Therapeutika
Medizin : Tiermodelle
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A double KO, a conditional KO as well as single KO mouse models for FFA2 and FFA3 (free fatty acid receptors 2 and 3), novel targets for diabetes therapies.

Flash 2 – Real-Time Magnetic Resonance Imaging (MRI)

Ref.-Nr.: 0707-4198-BC

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) is nowadays a leading mo¬dality for diagnostic imaging with about 100 million examinations per year worldwide. However, when invented by Paul Christian Lauterbur in 1973, MRI was too slow to allow for routine medical applications. A breakthrough was achieved in 1985 by the FLASH (Fast Low Angle Shot) technique developed by Jens Frahm and his team at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Germany. With FLASH the measuring time for a cross-sectional ...

FlipDroppy household dispenser for powders and granular food

Ref.-Nr.: 0109-6297-LI

Sensoren, Geräte und Komponenten

Accurate dispensing device for intuitive, spill free use

FlipDroppy laboratory dispenser for solid particles, powders, and beads

Ref.-Nr.: 0109-6297-LI

Sensoren, Geräte und Komponenten

An accurate dispensing device for powders and irregularly shaped particles

Free Standing Dry and Stable Nanoporous Polymer Films Made through Mechanical Deformation

Ref.-Nr.: 0903-6483-LC

Prozesse und Methoden (inkl. Screening)
Neue Materialien

Nanoporous membranes consist of pores with diameters in the range of nanometers and sub nanometers that can separate liquid or gaseous mixtures.
One of the key applications of nanoporous membranes is in water filtration to remove impurities, such as bacteria, viruses, and salts. Nanoporous membranes are also used in energy-related applications, such as gas separation and fuel cells. The membranes can also be used as electrodes in energy storage devices such as batteries and supercapacitors. ...

Generation of induced pluripotent stem cells with one or two reprogramming factors

Ref.-Nr.: 1012-3916-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

The cellular identity of mature cells that are confined in a specialized genetic expression profile can be overcome by introducing just a few genes that encode for so-called reprogramming factors [1]. By means of this intervention, also known as reprogramming, the cells then become pluripotent and represent induced pluripotent stem cells (iPS cells) [1]. Nowadays, numerous new cell culture models have been established based on reprogramming protocols that yield iPS cells. Such cell culture models ...

Generation of RNA therapeutics by conjugating NAD-capped RNAs to proteins

Ref.-Nr.: 0706-6285-IKF

Nukleinsäure-, Protein-, Zell-bezogene Technologien

Conjugation of a NAD-capped nucleic acid to a protein catalysed by an ART to generate novel RNA therapeutics.

Genome-Editing-Technologies - Cas9 double mutant with improved specificity compared to wild-type

Ref.-Nr.: 0306-5787-LI

Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien

The RNA-programmable DNA-endonuclease Cas9 is widely used for genome engineering, where a high degree of specificity is required. Though this is a mechanism well controlled by canonical base-pairing, there is evidence that Cas9 does accept mismatches under certain circumstances.
This might be seen as a threat to precision needed in genome engineering at least in environments where such high precision is ultimately needed and acceptance of mismatches needs to be avoided, e.g.: cellular gene ...

Genome-Editing-Technologies - Single compound or compound mix dramatically improve Homology-Directed-Repair (HDR)

Ref.-Nr.: 1306-5734-LI & 1306-5288-LI

Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien

Precise genome editing demands for homology-directed repair (HDR) by aiming to introduce a new double stranded DNA substituting for a homologous sequence but partially defect one. This substrate dependent reaction does compete with direct non-homologous end joining (NHEJ) of the double strand breaks. NHEJ is error-prone and is therefor mainly used for gene inactivation.
The rate of NHEJ is directly limiting the rate of HDR. For this reason HDR in vitro does occur on a very low level only and ...

Glue your proteins of interest together: Fast and ultra-specific enzymatic conjugation of a protein with another, synthetic compounds or even whole cells

Ref.-Nr.: 0109-5804-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Connectase is an enzyme that fuses target proteins or synthetic compounds via a small recognition tag, using a different reaction mechanism compared to known protein ligases. It prevents side reactions entirely and has absolute specificity, even in highly in complex solutions with minimum concentrations of target molecules.

GOLD gRNA - allows robust genome editing regardless of spacer sequence composition by super stable hairpin technology

Ref.-Nr.: 1306-6101-LI

Prozesse und Methoden (inkl. Screening)
Medizin
Forschungs-Reagenzien
Nukleinsäure-, Protein-, Zell-bezogene Technologien

A Cas nuclease such as Cas9 can introduce a DNA double strand break in a sequence target that is complementary to a 20-nt spacer sequence of its bound guide RNA (gRNA) when a protospacer adjacent motif (PAM) is present. The gRNA can be provided as duplex of spacer containing CRISPR RNA (crRNA) and trans-activating crRNA (tracrRNA). Or as a single gRNA (sgRNA) where crRNA and tracrRNA are fused by an artificial loop.
Hence a gRNA consists of the target-specific spacer and a constant part typically ...

Graphene Balls and electrochemical cells containing these materials

Ref.-Nr.: 0903-4524-LC

Neue Materialien

We offer a new simple and low cost technology to fabricate graphene-encapsulated metal or metal compound nanoparticles. The resulting hybrid nanoparticles are protected by granted substance claims in US, CN, TW and EP (DE, FR, GB, BE). Currently the patent protected graphene coated nano particles are discussed as high performance electrode materials in the lithium ion battery business (for example Samsung's "Graphene Balls").

High efficiency hydrodynamic collimation vacuum interface for atmospheric pressure ion sources

Ref.-Nr.: 1201-4433-BC

Sensoren, Geräte und Komponenten

In mass spectroscopy, many ion sources that transform the specimen to be tested into gas phase ions operate at ambient or elevated pressure. The generated ions have to be transferred into vacuum for further characterization, for instance in a mass analyzer.
The ion transfer into vacuum represents a major bottleneck. Because the pumping power increases rapidly with the size of an opening, long capillaries or small pinholes have to be used. Their transmission is commonly as low as 1%, in optimal ...

High Ferroelectricity: First Method for Production of Bulk SnTiO3

Ref.-Nr.: 1201-5559-BC

Neue Materialien

The invention relates to a new method of producing SnTiO3 for the use as a ferroelectric element. Tin titanates are known to be a class with various properties making it promising for many applications. The preparation of this material beyond thin films remained challenging.

Tin(II) oxide has a low disproportionation temperature of 350°C but the preparation of new materials is usually conducted at higher temperatures. Therefore, bulk SnTiO3 is not possible to be produced using existing ...

High-precision base editors for site-specific single nucleotide conversion

Ref.-Nr.: 0402-5782-MG

Prozesse und Methoden (inkl. Screening)

The CRISPR-Cas system is a powerful tool for site-specific genome editing. It allows for the inactivation or substitution of entire genes. However, most hereditary diseases in humans are caused by single point mutations, the correction of which requires only subtle changes to the DNA. Recently, base editors (BEs) were developed that allow the introduction of selective nucleotide substitutions. A Cas9 enzyme is fused to a nucleobase deaminase catalysing C-to-T mutations (by C-to-U deamination) ...

Higher Power Output and Simple Setup: New Source of Terahertz Radiation

Ref.-Nr.: 1201-6201-BC

Sensoren, Geräte und Komponenten

A novel concept for an efficient source of terahertz radiation was developed that is simple, powerful, and easy to use. It improves the possibilities to use THz radiation in science, medicine, security, communications, and other specialized applications.

THz radiation is expected to have high potential in various fields of science and technology. However, respective sources typically require highly specialized and complicated components like single crystals or cryogenics. Furthermore, a ...

Homogenous, TR-FRET-based method for measurement of RNA- and DNA-polymerase activity

Ref.-Nr.: 1013-4990-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

An innovative high throughput screening method for measurement of RNA- and DNA-polymerase activity at room temperature, based on time-resolved FRET.

Hot-wire anemometer with high temporal resolution

Ref.-Nr.: 0705-6586-BC

Sensoren, Geräte und Komponenten

The Differential Temperature Anemometry (DTA) is a cutting-edge technique that enhances the temporal resolution of flow velocity measurements in thermal anemometry. By leveraging the in-stantaneous temperature gradient of the sensor, DTA provides rapid and continuous data without the need for thermal equilibrium. This innovation represents a significant leap forward, offering high-speed, accurate flow detection for dynamic applications.

Hybrid Thin-Disk Amplifier

Ref.-Nr.: 1202-4510-WT

Sensoren, Geräte und Komponenten

Ultrafast amplifier systems providing high average powers (>10W) at repetition rates in the kHz regime suffer from severe accumulation of nonlinear phase inside the laser gain medium and other optical components within the amplifier. Implementation of chirped pulse amplification (CPA) constitutes a well-established method to reduce the peak intensity of the laser pulse during the amplification process [1, 2]. However, state of the art laser materials supporting high average output powers such ...

Improved Safety: Real-Time Monitoring of Thermal Power of a Nuclear Reactor

Ref.-Nr.: 0102-5836-WT

Sensoren, Geräte und Komponenten

The invention relates to a new and easy to use device for real-time monitoring of the thermal power of a nuclear reactor. It is based on the easy to access 16N decay rate in the cooling water. The robust and easy to implement method significantly improves the safety of nuclear facilities.

Nuclear reactors require high standards of safety and detailed information about changes are needed in order to control them in a safe manner. Besides detailed real-time simulations, direct ...

LABEL-FREE SEPARATION AND ANALYSIS OF MACROMOLECULES

Ref.-Nr.: 1629-4734-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten
Photonics

Laser device with kerr effect based mode-locking and operation thereof

Ref.-Nr.: 1202-4422-WT

Sensoren, Geräte und Komponenten

A laser device (100), configured for generating laser pulses, has a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12). The laser resonator (10) includes a first mode shaping section (13) which is adapted for shaping a circulating electric field coupled into the gain disk medium (11), and a second mode shaping section (14), which is adapted for shaping the circulating electric field coupled into the Kerr medium (12) independently of the electric field shaping in the first ...

Leaf metabolites as markers for mycorrhizal colonization of plant roots

Ref.-Nr.: 1602-5392-LI

Grüne Biotechnologie

Screening the level of specific blumenols in plant leaves allows simple implementation in marker assisted breeding and high-throughput analysis.

LITESEC - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

Ref.-Nr.: 0706-5707-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Arzneimittel-Darreichung
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

The LITESEC-T3SS (Light-induced translocation of effectors through sequestration of endogenous components of the T3SS) system represents a novel, fast, specific, and reversible method to control protein secretion into eukaryotic cells, enabling various medicinal and biotechnological applications, such as targeted drug delivery for tumor therapy.

Localized Oscillating Magnetic Fields: New Method for Accelerated MR Imaging

Ref.-Nr.: 0107-5557-BC

Bildgebung und Mikroskopie

The invention relates to a new method to reduce acquisition time in MR imaging. It is based on the use of localized temporal modulations of the main magnetic fields which provides further spatial information from the resonance signal. The method can be applied to parallel imaging.
MR imaging is among the most important tools for modern medical diagnostics with a unique range of applications. The imaging duration however limits the applicability for situations with movements within the volume ...

Lock-in thermography evaluation software for solar cells – Local I-V 2 (replacing Local I-V)

Ref.-Nr.: 1401-4359-WT

IT / Software / Bioinformatik

The efficiency of solar cells is strongly affected by local inhomogeneities. Especially inhomogeneities of the dark-current voltage (I-V) characteristic are of interest: The local dark current-voltage characteristic is a measure for the local recombination properties of the solar cell. Lock-in thermography performed in the dark (DLIT) can be used to detect and evaluate locally increased dark current densities.

Magnetically Coupled Worm Gear using stationary (here permanent) Magnets

Ref.-Nr.: 0207-6160-WT

Sensoren, Geräte und Komponenten

The invention relates to a new method of using magnetic forces in order to mechanically couple the worm of a worm gear with its corresponding worm wheel. According to the invented arrangement, a (permanent) magnet, i.e., a relatively hard magnetic material, magnetizes the worm, which is made from a relatively soft magnetic material. Thus, the magnetized worm develops attraction forces concerning the (also magnetically soft) tooth system of the worm wheel. In this way, it is sufficient to use comparably ...

MARS – software for robust and automatic backbone assignment of protein NMR spectra

Ref.-Nr.: 0707-5990-MG

IT / Software / Bioinformatik

MARS is a powerful program for robust automatic backbone assignment of proteins. MARS is applicable to proteins with extreme chemical shift degeneracy such as high molecular weight proteins and partially disordered or fully intrinsically disordered proteins. MARS is successfully used in many labs world-wide as evidenced by a huge number of citations.

Method and apparatus for optical frequency comb generation using a monolithic micro-resonator

Ref.-Nr.: 1202-3760-WT

Sensoren, Geräte und Komponenten

The invention relates to a monolithic optical frequency comb generator. Furthermore, the invention relates to a method of generating an optical frequency comb.

Method and radiation source for generating pulsed coherent radiation

Ref.-Nr.: 1302-3482-WT

Sensoren, Geräte und Komponenten

The present invention relates to a method of generating pulsed coherent radiation in the UV and XUV wavelength ranges. Furthermore, the present invention relates to a radiation source for generating pulsed coherent radiation based on a high harmonic generation (HHG).

Method for cell-free protein synthesis assays or other fluorescent assays in the context of cell-free protein synthesis

Ref.-Nr.: 0204-5479-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

An improved method to perform cell-free protein synthesis (CFPS) assays or other fluorescent assays in the context of CFPS with very low reaction mix volumes. Various additional advantages allow to significantly reduce costs and time.

METHOD FOR PRODUCING RANDOM NUMBERS ON THE BASIS OF QUANTUM NOISE

Ref.-Nr.: 1629-5565-WT

Sensoren, Geräte und Komponenten
Photonics

The invention relates to a new method for an improved production of random numbers and verification of their randomness. In order to do so, it uses the quantum mechanical properties of microscopic particles and structures. A number sequence is generated by means of a repetitive quantum mechanical random process. The measurement of this process is performed by a homodyndetection of an optical input signal, where the signal interferes with a local oscillator, e.g. a laser, at a central beam splitter ...

Method of producing autotrophic microorganisms with altered photorespiration and improved CO2 fixation

Ref.-Nr.: 0706-5602-IKF

Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)

Biological fixation of CO2 is an important process carried out by plants and several microorganisms, which can be harnessed for sustainable, biobased production of fuels and chemicals. Particularly, the fixation of CO2 by autotrophic microorganisms such as cyanobacteria and microalgae can be employed for converting CO2 into value-added products, such as commodity chemicals or fuels. However, the sustainable autotrophic production ...

Microfluidic cryo-fixation of biomass, e.g., cells, flagella/cilia, or proteins for (in particular) correlative light-electron microscopy systems

Ref.-Nr.: 0707-4032-BC

Bildgebung und Mikroskopie

Cryo-Electron Microscopy (Cryo-EM) today is revolutionizing biological research by revealing the structure of cells and proteins with atomic resolution and steadily improving contrast. However, the quality of the results depends critically on the sample preparation. High Pressure Freezing (HPF) and plunge freezing, both pioneered in the 1960s, still represent the state-of-the-art in sample preparation for cryo-EM. Both methods have poor timing precision, disrupt the natural environment of the ...

Microscopy: Differentiable model-based adaptive optics with transmitted and reflected light

Ref.-Nr.: 2022-6511-FG

Bildgebung und Mikroskopie

The invention relates to a method and illumination device for optimizing parameters of a physical light propagation model, in particular a light propagation model in a confocal laser microscope using a raster scanning method. The method can determine aberration corrections that go beyond a predetermined model of aberrations, such as combina-tions of Zernike modes.

Milestone for Plasmonics: The Plasmon Generating Transistor

Ref.-Nr.: 1201-4765-BC

Sensoren, Geräte und Komponenten

The invention relates to a new method for a plasmon emitting transistor that operates in the single quantum regime. It is a major step towards future data processing technology that is no longer based on electric currents but on the transition of light.

Developments over past decades have gradually increased the performance of computer chips, but new technologies are needed to overcome the sizing limit of classical transistors. Replacing the role of electrical currents by the use of light ...

MINSTED fluorescence localization and nanoscopy

Ref.-Nr.: 0707-6171-BC

Bildgebung und Mikroskopie

The MINSTED method is an innovative technique for determining the position of a singularized fluorophore molecule within an object. Traditional methods in molecular imaging faced challenges in achieving high resolution due to limitations in fluorescence microscopy. Existing solutions like STED (Stimulated Emission Depletion) microscopy improved the spatial resolution but rely on high illumination intensity and/or sample exposure, which can lead to thermal issues and photochemical reactions. MINSTED ...

Modular low light level sensors: a scalable approach

Ref.-Nr.: 0206-5874-BC

Sensoren, Geräte und Komponenten : Sensoren

A scalable and easy to handle method for the creation of larger (up to square meters) low light level detectors is disclosed. While the fast read-out times of a single detector is kept, the area covered by the detector ensemble (dramatically) increases. The large area is enabled by transversal connection of hybrid “base cells”. These “base cells” consist of vertically stacked tiers of (i) a detector array, (ii) a first level electronic read-out, and (iii) and a second level read-out which ...

Molecularly defined non-infectious synthetic virus-like particles to mimic biophysical features of natural pathogens

Ref.-Nr.: 0105-6291-IKF

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A synthetic virus-like particle, comprising a lipid bilayer, that can be adjusted precisely to mimic biophysical features of various natural pathogens. The lipid bilayer can also be equipped with relevant molecules such as the SARS-CoV-2 spike protein ectodomain.

Monoclonal Antibody to Detect Neutrophil Extracellular Traps via a Novel Post Translational Histone Modification

Ref.-Nr.: 0305-5699-LI

Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Antikörper

A novel tool to detect and quantify NETs using a molecular feature of NET formation that has never been proposed as a marker for NETs before

Mouse model for mitochondrial diseases

Ref.-Nr.: 1013-4827-IKF

Medizin : Tiermodelle
Forschungs-Reagenzien

A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.

Multi-well Exosome Libraries for High-throughput In Vitro Cell Activity Assays

Ref.-Nr.: 0707-6429-MG

Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Extracellular vesicles (EVs) such as exosomes and microvesicles participate in the intercellular communication by transferring bioactive molecules between various cells and tissues. Such EVs cross-talk was shown to play important roles in cell–cell communication, cell maintenance, disease progression and therapy. By containing disease specific markers, EVs can also act as diagnostic biomarkers. In addition, synthetic EVs are used as carriers to deliver drugs or mRNA-based vaccines to specific ...

Multichannel coil for UHF MRI

Ref.-Nr.: 0107-4677-BC

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Exploiting the benefits offered by magnetic resonance imaging (MRI) at ultra-high fields (≥ 7 Tesla) requires optimized radiofrequency (RF) coils. MRI at UHF operates in a regime where the RF wavelength is comparable to the dimensions of the sample size, resulting in an inhomogeneous distribution of the transmit field (B1+) and in an impaired image quality. An array of independent transmit coils arranged in multiple rows provides the degrees of freedom to influence the ...

Multifunctional RFID-based Platform for Animal Observation and Manipulation

Ref.-Nr.: 0214-5247-MG und 0214-5440-MG

IT / Software / Bioinformatik : (andere) Software
Sensoren, Geräte und Komponenten : Sensoren
Sensoren, Geräte und Komponenten : Geräte
Sensoren, Geräte und Komponenten : Komponenten

≠¡]} Julius Kramer

An efficient system to monitor and control animal behavior in wildlife as well as in laboratory settings

N-substituted pyridiniophosphines, processes for their preparation and their use

Ref.-Nr.: 0042-4938-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.

Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.

Nanographene-based dyes as high performance probes for super-resolution microscopy

Ref.-Nr.: 0903-5658-LC; 0903-5696-LC

Analytik
Bildgebung und Mikroskopie
Neue Materialien

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).

They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.

These nanographene ...

Near-Unity Efficiency: Novel Light Collecting Antenna for Quantum Technologies

Ref.-Nr.: 1629-6049-WT

Photonics

The invention relates to a new concept for a high efficiency light antenna, namely the Truncated Omnidirectional Reflector (TOR). It is well suited for obtaining directional emission and efficient fiber coupling from various types of light sources like single photon emitters.
Especially in the fast-growing field of quantum technologies efficient collectors for solid-state single photon emitters are needed. Achieving collector efficiencies of more than 95% into the fundamental Gaussian mode, ...

Neuro-epithelial stem cells (NESC) capable of forming both central nervous system (CNS) and peripheral nervous system (PNS) neurons

Ref.-Nr.: 1012-4430-LI

Prozesse und Methoden (inkl. Screening)

File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)

A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.

New KDAC assay and selection system

Ref.-Nr.: 0803-5480-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

We present an extremely sensitive, reliable and fast novel Lysine deacetylase (KDAC) assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion.

We furthermore offer a bacterial selection system that can help engineer KDACs. The selection system uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby ...

Noise Free Imaging: Incoherent Light Source for Microscopy

Ref.-Nr.: 1629-5817-WT

Bildgebung und Mikroskopie

The invention relates to a new light source exhibiting a high level of spatial incoherence. This enables microscopic imaging with reduced artefacts and low intensity noise. It comprises a pulsed laser whose beam properties are improved is by a multimode optical fiber.
Full field microscopic imaging is an essential technique in medicine and beyond, but the occurrence of noise strongly limits its applicability. Coherent light contributes considerably to the formation of artefacts. Hence the ...

Non-collinear spin-valve

Ref.-Nr.: 1201-5998-BC

Sensoren, Geräte und Komponenten

A classical spin valve (SV) is a device in which the electrical resistance depends on the relative position of the magnetic moments of two ferromagnetic (FM) layers: with parallel (P) and antiparallel (AP) ordering, the SV resistance is minimum and maximum, respectively. Nowadays SVs are actively used in magnetic sensors, hard disk read heads and magnetic random-access memory. Thus, the SV, analogous to a transistor in conventional electronics, is a binary (digital) device. Here we offer a new ...

Novel 20S proteasome inhibitors

Ref.-Nr.: 0706-6249-IKF

Medizin

The proteasome is a central component of the protein degradation machinery in eukaryotic cells and plays a role in regulating cell cycle, neoplastic growth and metastasis. Disruption of this degradative process with small molecule inhibitors against one or more catalytic subunits has implications in a number of human diseases such as cancer, inflammation and ischemic stroke and has exposed the proteasome as an important therapeutic target. Three proteasome inhibitors have so far received regulatory ...

Novel biomarker for diagnosis and targeted therapy of Acute Myeloid Leukemia (AML)

Ref.-Nr.: 0204-6248-MG

Medizin : Diagnostika

New biomarker candidates for diagnostic sub-classification of AML patients with elevated expression of mitochondrial proteins and subsequent targeted therapy with BCL-2 inhibitors like venetoclax and/or agents targeting mitochondrial complex I

Novel Biomarkers for Ageing and Metabolic Health

Ref.-Nr.: 1013-5354-IKF

Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...

Novel compounds against rust and smut fungi

Ref.-Nr.: 0706-6146/6147/6148-IKF

Grüne Biotechnologie

Rust and smut fungi are plant pathogens which cause diseases of considerable relevance in agriculture. Both fungi are biotrophic and require living plant tissue for proliferation. Instead of killing their host plants, they manipulate host cells to assure that these sustain fungal growth. During the infection, the fungi release an entire cocktail of so-called effectors which function either in the interaction zone between fungus and host or are delivered to plant cells. Effector proteins suppress ...

Novel compounds for plant disease control

Ref.-Nr.: 0707-5356-MG

Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Grüne Biotechnologie

Plant pathogenic fungi, oomycetes and bacteria have highly diverse lifestyles, infection strategies and morphologies. Therefore, pesticides frequently target basic cellular processes, as these are well characterized and often very similar among plant pathogens. Many pesticides target enzymes that play a role in e.g. nucleic acid synthesis, respiration, cell division and other essential cellular processes. However, the molecular ...

Novel Imine Reductases (IREDs) for the enantioselective preparation of primary amines

Ref.-Nr.: 0706-5617-IKF

Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Chiral amines are crucial building blocks for the synthesis of bioactive compounds in the pharmaceutical, and agrochemical industry. Chiral amines are also important for chemical synthesis as chiral auxiliaries or resolving agents for diastereometric salt crystallizations. In recent years, biocatalysts, particularly imine reductases (IREDs) and reductive aminases capable of reducing imines to chiral amines were discovered and developed for industrial application. However, the portfolio of current ...

Novel method for analysis of complex carbohydrate structures by ion-mobility mass spectrometry (IM-MS)

Ref.-Nr.: 0401-5070-MG

Analytik

Carbohydrates form one of the major classes of biological macromolecules in living organisms, but structural analysis and the quality control of carbohydrate structures represent a major challenge due to the frequent occurrence of isomers that are difficult to distinguish using established techniques.

Changes in protein glycosylation are frequently identified in the context of diseases. For example, alterations in N-glycan profiles from blood plasma have been found to correlate with pathological ...

Optimised Flow-Through-Cell for Online-Microscopy

Ref.-Nr.: 1402-5292-BC

Neue Materialien

For the evaluation of crystallisation processes, process parameters like temperature and concentration can be easily measured. However, to measure the crystal size distribution continuously is a challenging task.
Different methods relaying on back scattering or reflection of monochromatic light can be applied that yield chord-length distributions, which often deviate from the actual crystal or particle size distribution. For analysing the true crystal dimensions and, additionally, the crystal ...

Optimization of Multi-Channel Coil for Magnetic Resonance Imaging

Ref.-Nr.: 1302-4127-BC

Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) requires optimal radio-frequency (RF) coil performance that ensures the highest RF magnetic field per unit power delivered to the coil, while maintaining the highest achievable RF field homogeneity. For MRI at high magnetic field level, it is important to use a multi-channel transmit coil for producing the desired RF field. However, it is impossible to design a multi-channel coil without considerable coupling between its coil elements. The major challenge in multi-channel ...

Overcoming disease persistence in myeloproliferative neoplasms (MPN) through combinatorial inhibitor treatment

Ref.-Nr.: 0204-5895-MG

Medizin : Therapeutika

The mRNA processing factor YBX1 is a novel target in Myeloproliferative neoplasms (MPNs), which in an combinatorial inhibitor treatment with JAK inhibitors completely overcomes disease persistance.

PALES software package

Ref.-Nr.: 0707-5926/6382-MG

IT / Software / Bioinformatik : Bioinformatik

NMR spectroscopy is a unique technique for the assignment of the constitution, configuration and conformation of small molecules, natural products, proteins, nucleic acid and oligosaccharides. NMR-derived residual dipolar couplings overcome limitations associated with traditional NMR data, avoid data misinterpretation and provide novel insights into structure-activity relationships. In order to leverage the full potential of residual dipolar couplings, however, powerful dedicated software and ...

Parallel glycan synthesis on a membrane

Ref.-Nr.: 0401-5724-MG

Prozesse und Methoden (inkl. Screening) : Produktion

A process for parallel synthesis of glycans on cellulose membranes by using a novel VaporSPOT method and an experimental setup that ensures controlled conditions suitable for glycosylation reactions.

Parallel-imaging time-of-flight momentum microscope

Ref.-Nr.: 1401-4572-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten : Geräte

The state of an electron is completely defined by its momentum and spin. In processes like electron diffraction or photoemission electron ensembles are generated which have a characteristic 3D distribution of momentum and spin. To examine such events the three components of the momentum vector have to be measured. Up to now, the momentum distribution of an ensemble of charged particles was typically measured using energy-dispersive spectrometers based on sequential approaches (sequentially changing ...

Peptides and methods for carbon-carbon bond formation

Ref.-Nr.: 0706-5856-IKF

Prozesse und Methoden (inkl. Screening) : Chemische

One of biotechnology’s central goals is the synthesis of multicarbon compounds under mild and sustainable conditions from renewable resources. This requires biocatalysts and methods that enable selective C-C bond formation (carboligation) between two carbon units.

Moreover, optically active compounds can be used for optically resolving agents of medical or agriculture supplies such as 2-amino-1-butanol which is a starting material of the antituberculous drug ethambutol, diltiazem hydrochloride ...

PLAYFUL Reactive Programming for Orchestrating Robotic Behavior

Ref.-Nr.: 0104-5603-BC

IT / Software / Bioinformatik

Playful is a scripting language for orchestration of Python modules. Playful allows developers to both organize the logic of activation in reactive behaviour tree and setup sensory-motor couplings, making it especially useful for robotics

PONy Dyes – Fluorescent Dyes with Phosphorus Substituents

Ref.-Nr.: 0707-5297-BC

Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. In particular, the sensitive and stable imaging of cellular components depends on the favourable combination of chemical, biological and physical factors. The availability and proper choice of fluorescent dyes is a key factor to success in the entire labelling and imaging procedure. Due to their superior brightness and photostability, synthetic dyes represent an attractive alternative ...

Precise LIDAR Devices: Metasurface for Large-Angle Beam Steering

Ref.-Nr.: 1201-6235-BC

Photonics

The invention relates to a new device for precise large-angle beam steering at an extended wavelength range. It is based on an electrically-controlled metasurface and allows for the implementation in advanced LIDAR systems.

Metasurfaces are used to change properties of light and can therefore be used to steer an incoming beam. However, common devices are lacking spatial resolution and are thus limited to small angles. Furthermore, state-of-the-art metasurfaces for respective applications ...

Precision Microscopy: Detector for Changes in Direction of a Light Beam

Ref.-Nr.: 0105-5623-BC

Bildgebung und Mikroskopie

The invention relates to a new method for light beam angle detection that is based on interferometry. High precision and sensitivity for slight changes of the beam direction can be achieved with this method.
For high precision light microscopy, the light beam must be aligned accurately, and the beam direction stability must be ensured in order to maintain a sufficient imaging resolution over longer periods of time. In standard microscopy environments even small temperature changes can result ...

Predicting concentrations, reactions rates and rate constants in biochemical networks

Ref.-Nr.: 0402-5469-MG

Analytik
IT / Software / Bioinformatik : Bioinformatik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.

Process for producing a mesoporous carbide

Ref.-Nr.: 0041-4518-WT

Neue Materialien

Mesoporous materials present a large surface-to-volume ratio providing sites for catalysis, molecular separation, adsorption or chemical sensing. Some of the classical mesoporous materials employed include silica, alumina, zirconia, zeolites, and other diverse oxides such Ti or Co, and they are synthetized by routes as self-assembly, sol-gel, spray drying and some variations of these methods known in the state of the art. Additionally, some elements of the platinum group such as Pd, Ru, and their ...

Protein Cristallography (XDS)

Ref.-Nr.: 0105-1318-WT

IT / Software / Bioinformatik

X-ray Detector Software for processing single-crystal monochromatic diffraction data recorded by the rotation method.

Protein Epitope Signature Tags (PrESTs) for SILAC-based absolute protein quantification

Ref.-Nr.: 0204-4338-MG

Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Direct quantification of the absolute amount of multiple proteins in one a SILAC experiment using Protein Epitope Signature Tags (PrESTs) which consist of a short and unique region of the protein of interest as well as purification and solubility tags and are expressed recombinantly in E. coli

Rare-earth free magnetic material suitable for permanent magnet production

Ref.-Nr.: 1303-6197-LC

Neue Materialien

Driven by the favourable operational effectiveness of neodymium iron boron (NdFeB) magnets, there has been a considerably rising demand for neodymium in permanent magnet manufacturing. According to Spherical Insights & Consulting the global neodymium magnet market size was valued at 2.3 Billion US$ in 2022 and is expected to reach 3.83 Billion US$ by 2032. As the market for rare earth materials is heavily influenced by Chinese supplies, which causes supply and price uncertainties, end users ...

Reducing phase singularities in speckle interferometry

Ref.-Nr.: 1629-5142-WT

Sensoren, Geräte und Komponenten : Geräte

Speckle interferometry is an established metrology technique for the characterization of rough objects. Deformations of rough objects under a load can be determined, as well as – with the help of an additional second wavelength – the surface shape of the object under test. As an illustration, Figure 1 (left) shows the so called raw phase as a result of a deformation measurement on a metal plate. The shape and the density of the fringes indicate the response of the metal plate to the load.
Owing ...

Reflection Microscopy: Ready to Use Neural Networks for Wavefront Correction in Adaptive Optics

Ref.-Nr.: 2022-6510-FG

Bildgebung und Mikroskopie

The invention relates to a method for wavefront correction in adaptive optics compatible with laser scanning microscopy based on reflected light and deep neural networks. For network training sample aberrations are generated in the excitation and detection path by means of spatial light modulators, and the corresponding reflected focus images are recorded by CMOS cameras. After training, the network can disentangle and independently correct excitation and detection aberrations. The predicted aberration ...

Reliable and Independent: New Automated Glaucoma Detection Method

Ref.-Nr.: 0705-5468-BC

Bildgebung und Mikroskopie

The invention relates to a newly developed image processing method for optical coherence tomography (OCT) to be used in particular on the (human) eye’s anterior chamber. Said OCT images are used to diagnose glaucoma, but the required assessing methods are not yet available as automated and fully unsupervised.

Glaucoma is the main reason for irreversible blindness. Early-stage diagnosis is typically based on images of the anterior chamber. Various automated techniques for image analysis ...

Remote and Spatiotemporal Control for the Actuation of Biocompatible Membranes through the Irradiation with (visible) Laser Light

Ref.-Nr.: 0903-6221-LC

Neue Materialien

The invention relates to the actuation of micro- and nanostructures controlled by external stimuli. Photo-actuation utilizes the conversion of light via phonons into motion through reversible chemical and physical processes and enables remote and spatiotemporal control of the actuation. Here, we report a fast light-to-motion conversion in few-nanometer thick bare polydopamine (PDA) membranes stimulated by (visible) light. Light-induced heating of PDA leads to desorption of water molecules and ...

Safety apparatus and method for monitoring a light path of a laser beam, and applications of same

Ref.-Nr.: 1801-6105-WT

Sensoren, Geräte und Komponenten

The invention enables a fast and effective safety for persons (or obstacles) being in danger of hitting the beam of powerful lasers like YAG lasers. While being extremely powerful, the YAG laser light is invisible to the human eye. The safety mechanism is based on a harmless, visible laser light, i.e., cylindrically surrounding the YAG beam a shutter mechanism (i.e., with an entrance of cylindrical symmetry and made of synthetic material). The safety laser light is controlled by a ring (or sector) ...

Scalable coupling part machined from one workpiece

Ref.-Nr.: 0704-5610-BC

Sensoren, Geräte und Komponenten : Komponenten

The invention describes an easy and cheap to produce, compact coupling part, manufactured out of one workpiece. This part, scalable for shaft diameters as low as 1 mm upwards, enables a quick and secure, backlash-free one- or two-sided engagement of shafts without the need for working space or additional tools (like a screwdriver). If requested, torque limited coupling (in one or both rotation directions) is possible. The production methods comprise a variety of materials and manufacturing processes. ...

Sensor for the Carrier-envelope Phase of Short Laser Pulses: A Measuring Device and a Laser Control Device

Ref.-Nr.: 1202-4253-WT

Sensoren, Geräte und Komponenten

We present a sensor for the carrier-envelope phase of a few-cycle femtosecond laser. The sensor uses the electron current emitted from a nanoscale metal tip onto which we focus high-repetition-rate laser pulses.

Possible applications of this sensor are in the field of the technique of controlling and using pulse lasers, in particular used for measuring or high-power irradiation purposes.

The size of such a simple stand-alone sensor device for the carrier-envelope phase could be in ...

SIMNRA 7 software

Ref.-Nr.: 1801-4849-WT

IT / Software / Bioinformatik

SIMNRA is a Microsoft Windows program for the simulation of energy spectra for ion beam analysis with incident ions from about 100 keV to many MeV. SIMNRA can be used for the simulation of Rutherford backscattering (RBS), elastic backscattering with non-Rutherford cross-sections (EBS), nuclear reaction analysis (NRA), elastic recoil detection analysis (ERDA), and medium energy ion scattering (MEIS). Almost 3000 different non-Rutherford and nuclear reactions cross-sections for incident protons, ...

Simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples

Ref.-Nr.: 0105-5434-IKF

Analytik

A simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples, with various applications such as enzymatic assays, clinicals tests, and as point of care tests in the field of ageing.

Simultaneous multi-color fluorescence microscopy with improved spatio-temporal resolution and image contrast

Ref.-Nr.: 0707-5644-BC

Bildgebung und Mikroskopie

Fluorescence microscopy is one of the key techniques in the life and materials sciences, with applications ranging from routine diagnostics to state-of-the-art research investigations. Key to this success has been its intrinsic advantages combined with continuous improvement in its fundamental features such as resolution, speed, and sensitivity.


Two key challenges are fast single-fluorophore imaging of multi-color samples. This need arises in a broad range of settings such as very high-resolution ...

Single Photon Detection: Advanced DePFET with High Amplification

Ref.-Nr.: 1201-5766-BC

Sensoren, Geräte und Komponenten

The invention relates to a new and improved concept for Depleted p-channel Field Effect Transistors (DePFET) detectors that provides a significantly higher intrinsic amplification. By the extension of the transistor layout, former limitations were overcome.
DePFETs are insufficient for many applications in terms of the achievable intrinsic amplification. This is since shorter transistor channels needed for high amplification would increase the detector noise caused by impact ionization events.
Additional ...

SNOM: New Sensitive Detection Method for Small Periodic Signals

Ref.-Nr.: 0302-6225-BC

Sensoren, Geräte und Komponenten

The invention relates to a new detection method for small periodic signals in Scanning Near Field Optical Microscopy (s-SNOM). Solving the problem of the rapid sampling rates necessary for lock-in amplification, the method is a powerful new readout system for various other applications as well.

Lock-in detection is a widespread technique, which enables the detection of very small periodic signals. However, it imposes constraints between the lock-in modulation frequency and the sampling ...

Soft Capsule Endoscope - "B-MASCE"

Ref.-Nr.: 0104-5410-BC

Sensoren, Geräte und Komponenten

Im Zuge der stetigen Weiterentwicklung und Nachfrage auf dem Gebiet der minimal invasiven Chirugie wurde am Max-Planck-Institut für intelligente Systeme in Stuttgart im Team von Herrn Prof Sitti für patientenfreundliche Magen-Darm-Untersuchungen ein kabelloses kapselförmiges Endoskop in Pillengröße, das sogenannte "B-MASCE" entwickelt. Die aus einem Elastomer bestehende Kapsel dient hierbei sowohl als Gehäuse als auch als Federelement für die Nadel. Über in der Kapsel eingebaute Magnete ...

Stable, site-specific conjugation of His-tagged proteins via cobalt (III) carbonate reagents

Ref.-Nr.: 0105-5774-IKF

Analytik
Prozesse und Methoden (inkl. Screening) : Chemische
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

This invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier.

Substituted Imidazolium Sulfuranes and their use as novel Electrophilic Group-Transfer Reagents

Ref.-Nr.: 0042-5063-LC

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

The ability of hypervalent iodine compounds to act as electrophilic group-transfer reagents has been extensively exploited during the last several years in a variety of synthetically useful transformations
like cyanations and alkynylations. Now it was found, that novel imidazolium sulfuranes, which are isolobal to I(III) species and also depict the key threecenter four-electron bond motive, can be used as an alternative platform for the development of new electrophilic group-transfer reagents.

Imidazolium ...

Suicide gene-armed oncolytic virus for enhanced cancer treatment

Ref.-Nr.: 0204-4297-IKF

Medizin

Cancer stands as the second-leading cause of human death worldwide, following closely behind cardiovascular and cerebrovascular diseases, with a prevalence that continues to rise. In particular, hepatocellular carcinoma is a significant health concern, ranking as the third leading cause of cancer-related deaths, and with a rising incidence rate due to increasing levels of cirrhosis and NAFLD/NASH.

Despite recent advancements in cancer therapies, ...

SUMOvera: A Truly Orthogonal Cleavage Module

Ref.-Nr.: 0402-5439-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

Superamphiphobic membranes for gas exchange and scrubbing

Ref.-Nr.: 0903-4616-LC

Neue Materialien

Novel gas exchange membranes based on superamphiphobic coatings applied on metal meshes were created and tested in different applications, like gas scrubbing and blood oxygenation.
By using the novel membrans drawbacks of traditional membranes - like insufficient wetting, plugging and depositions chemical incompatibility and temperature instability - can be avoided.

Sustainable High-Performance Energy Storage: The Solar Battery

Ref.-Nr.: 0104-5740-BC

Neue Materialien

The invention relates to a new solar battery half-cell that can be recharged by natural resources like sunlight. Remarkable sustainability is provided by the possibility to use sunlight as a source of primary energy and by solving the problem of low capacity of state-of-the-art battery technologies.

Sustainable solutions for efficient storage of electrical energy are of great importance for the global energy transition and other applications. Typical batteries, however, are often charged ...

Tet-inducible “gePSI” protein reversibly regulates eukaryotic ribosomal protein synthesis in a cell-type specific manner allowing to impose and release protein synthesis inhibition in a select subset of cells in mixtures

Ref.-Nr.: 0602-5504-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

Proteins are the main functional units within cells. Their regulated synthesis and degradation are crucial for controlling biological processes. In all cells, protein synthesis is used to respond to extra- and/or intracellular cues to remodel cellular function. Previous studies probing the role of protein synthesis have used chemical inhibitors, often common antibiotics, which are effective but lack functional and cell-type specificity when applied to a mixture of cells.

The Camera Offset Space: Real-time Potentially Visible Set Computations for Streaming Rendering

Ref.-Nr.: 1200-5472-BC

IT / Software / Bioinformatik

The presented technology offers an enhanced streaming rendering pipeline that enables the display of high fidelity, high framerate and high solution for noval views in real time on thin lightweight HMDs suitable especially for VR experiences.

How does it work?

The key idea of this technology is based on a novel algorithm for Potentially Visible Set (PVS) creation: the camera offset space (COS), which for a given point on the image plane provides information under which camera ...

Touchless Positioning Interface: The Precise Nanosheet Moisture Sensor

Ref.-Nr.: 1201-4882-BC

Sensoren, Geräte und Komponenten : Sensoren

The invention relates to a new precise sensing device for gas and vapor that is based on a 2D nanosheet material. A remarkably high sensitivity allows for the application in smart touchless interfaces to operate future digital devices.

Sensors for environmental changes are one of the most promising approaches for touchless interface devices but state-of-the-art technologies are not satisfactory. They typically exhibit too long response times.

With its capability to resolve sub-centimeter ...

Towards New Optical Devices: The Electrically-Controlled Dynamic Metasurface

Ref.-Nr.: 1201-5777-BC

Photonics

The invention relates to a new dynamic optical component based on a metasurface that can be operated electrically at visible frequencies. Realizing pixel level addressability of the metasurface properties paves the way towards the next generation of optical devices for data storage and communication.

Nanoantennas on a metasurface are used to directly change properties of light but are typically limited to static effects. However, state-of-the-art devices with optical reconfigurability are ...

Ultracompact medical ventilation system

Ref.-Nr.: 0901-6012-WT

Medizin
Sensoren, Geräte und Komponenten

Comparison of the ventilation unit (left hand side) with a tennis ball.

The invention relates to a new, ultracompact non-invasive medical ventilation system. The BIPAP (Biphasic Positive Airway Pressure) ventilation unit, of size and weight of a tennis ball, is easy to handle and allows low-budget mass production. It can be powered by a rechargeable battery-pack – a great advantage in case of mobile use or damaged/unstable infrastructure leading to frequent blackouts. These benefits, ...

Ultrarapid cryo-fixation during live observation on a fluorescence microscope

Ref.-Nr.: 0803-6035-IKF

Bildgebung und Mikroskopie

A ultrarapid cryo-arrest directly on a multimodal fluorescence microscope that preserves molecular activity patterns during observation of their dynamics in living cells at any timepoint.

Uniform Deposition of Large-Area Multicomponent Coatings using Laser Irradiation Scanning of Predesigned Targets

Ref.-Nr.: 1201-4172-BC

Sensoren, Geräte und Komponenten

Pulsed laser deposition (PLD) facilitates efficient production of thin films using a laser ablation technique. Targets are selected according to the coating desired. Multiple targets are either moved mechanically to the incidence area, or they are fixed so that the laser beam is alternatively focused on each of them. Multiple targets are, however, known to cause discontinuities, whereas single multicomponent target usually doesn’t ensure compositional homogeneity. The technology presented here ...

Unique multifunctional oligonucleotide enabling ultrafast RNA-protein interactions in cells and other uses thereof

Ref.-Nr.: 0214-5029-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Unique multifunctional oligonucleotide for the ultrafast transcriptome-wide identification of RNA-binding protein (RBP) targets.

Water content sensor for biological soil crusts

Ref.-No.: 0901-4720-WT

Sensoren, Geräte und Komponenten

In arid and semiarid regions biological soil crusts (BSC) cover about 1/3 of the soil surface. As far as it is known, these BSC (consisting of cyanobacteria, algae, fungi, bryophytes, and other bacteria living in contact with soil particles) are crucial for the global terrestrial carbon and nitrogen cycle. The water status plays a major role, since their water content directly controls the activity of these poikilohydric organisms.

Xenorhodopsin - a new inward-directed proton pump for an alternative optogentic approach

Ref.-Nr.: 0601-5295-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

The development of the cation channel channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii by Prof. Ernst Bamberg and his colleagues, and its application to light-induced modulation of neurons paved the way for the field of optogenetics.
Over time the light-gated cation channel channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience. Based on the pioneering work on ChR2 new variants have emerged, differing in their spectrum of light absorption, their kinetic ...