Technologieangebote

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Analytik

IT / Software / Bioinformatik

Prozesse und Methoden (inkl. Screening)

Medizin

Forschungs-Reagenzien

Nukleinsäure-, Protein-, Zell-bezogene Technologien

Grüne Biotechnologie

Bildgebung und Mikroskopie

Neue Materialien

Sensoren, Geräte und Komponenten

Photonics

Erweiterte Suche

 

Treffer

Ref.-Nr.: 0104-5931-BC

Bildgebung und Mikroskopie
Neue Materialien

"As a result of the evermore-enhanced super resolution microscopic techniques that allow observation of biological processes up to the molecular level in living cells the demand for fluorescent dyes owning the capability of specific binding to molecules like proteins as label for visualization aspects is increased.

A new class of rhodamine derivates that meets all requirements for the use in such biological environment could be developed in the group of Prof. Stefan Hell, Max Planck Institute ...

Ref.-Nr.: 1201-5155-BC

Sensoren, Geräte und Komponenten

Metal-insulator-metal (MIM) diodes are very promising for application as rectennas for solar energy harvesting, photo-detectors and high frequency mixers. Good MIM diode performance requires a high asymmetry, a strong nonlinearity, a large responsively, as well as a low resistance or a high on-current. These figures of merit are mainly determined by the work function difference of the electrodes, and the barrier height between the insulator and the electrode materials. In the design of MIM diodes, ...

Ref.-Nr.: 1012-5677-LI

Prozesse und Methoden (inkl. Screening)

File no.: MI-1012-5677-LI-ZE
(liked to MI-1012-4430-LI-ZE describing the generation of neuro- epithelial stem cells as precursors for microtissue generation)

A robust method for producing and analyzing highly homogenous human neural organoids.

Ref.-Nr.: 0104-5132-BC

Sensoren, Geräte und Komponenten

Reversible adhesion can be used to transfer or to manipulate objects. Especially if the objects are small and/or fragile their manipulation become very challenging. Intermolecular forces such as Van-der-Waals can be used to achieve a strong adhesion between the objects. Moreover, surface functionalization and the creation of nano- and microstructures can be used to improve these adhesion properties. Unfortunately, the adhesion becomes insufficient if the surfaces are wet or rough. Another problems ...

Ref.-Nr.: 0301-4550-LI

Medizin : Diagnostika

With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...

Ref.-Nr.: 0402-4816-MG

Grüne Biotechnologie

UV-B radiation is a major damaging agent causing damage to plants, tissues and human or animal skin upon exposure. To persist strong UV-B radiation plants produce additional antioxidant sunscreen pigments that belong to the chemical compound family of phenylpropanoids. Since many conventional compounds with sunscreen protection potential do not enter the market due to toxic side effects or they bear the risk to become environmental pollutants when accumulating in natural resources, application ...

Ref.-Nr.: 0106-5185-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions

Ref.-Nr.: 1402-5459-BC

Forschungs-Reagenzien : Antikörper

Human influenza A virus (IAV) is responsible for seasonal disease in people and can cause worldwide pandemics. The main lines of defense against IAV are vaccines and antiviral drugs.

Influenza vaccines, including killed and live vaccines, recombinant virus-like particles and viral particles, have been available commercially for many years. Typically, the composition of influenza vaccines is based on the major influenza virus strains causing infection in the previous season. Accordingly, ...

Ref.-Nr.: 1305-5341-MSG

IT / Software / Bioinformatik : Bioinformatik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Cholestatic liver diseases are a heterogeneous group of disorders resulting from genetic, metabolic and congenital defects, as well as DILI (drug-induced liver injury, a leading cause of attrition during drug development).

Current diagnostic techniques for DILI and cholestasis are based on the detection of serum markers and imaging methods such as computer tomography. However, these have a low resolution and only provide a limited understanding of the underlying disease etiology. Therapeutic ...

Ref.-Nr.: 0041-5034-WT

Prozesse und Methoden (inkl. Screening)

Noble metals are used in various fields of application such as catalysis, jewelry, high technology electronic equipment, equipment for glass industry and many others. As noble metals are rare and hard to extract from the ores or exhausted compounds, many efforts have been undertaken to establish an efficient recycling process. Due to their corrosion resistant properties, noble metals recycling by means of dissolution is limited to the usage of very reactive and harmful chemicals such as Aqua Regia. ...

Ref.-Nr.: 0402-5163-MG

Analytik

In contrast to target-based drug discovery, phenotypic screening discloses the effect of a compound on a biological system without revealing its mode of action or its interaction sites. Phenotypic screening has delivered several new valuable drugs, however, the major challenge remains target deconvolution (1). In recent years, “omics” techniques and bioinformatics have brought significant advances to target identification in drug discovery phenotypic screening. However, such analyses can become ...

Ref.-Nr.: 0705-5158-BC

Neue Materialien

For sieving and separation purposes porous materials with adjustable sizes and shapes of the pores as well as tunable mechanical properties are required. The existing materials such as sintered materials, open-cell foams or cemented aggregates can be made porous but they are either fragile or can collapse for large deformation. Therefore, chemically inert and damage resistant porous materials with adjustable permeability as well as mechanical and geometrical properties that can sustain large deformation ...

Ref.-Nr.: 0041-5601-WT

Sensoren, Geräte und Komponenten

The study of mechanical properties of materials at high temperatures at the microstructural length scale requires dedicated testing setups. An accurate measurement of the sample temperature is vital for reliable testing. Most of the successful current testing platforms record the temperatures of the sample and tip near the heating sources but not at the respective surface. As a consequence, due to spatial and temporal thermal gradients a reliable surface temperature cannot be measured today. Even ...

Ref.-Nr.: 0705-4974-BC

Sensoren, Geräte und Komponenten

Conventional mechanical zippers find manifold applications for luggage, clothing or even industrial applications. However, their design features significant disadvantages. In particular, they require the use of both hands by the user to align the ends of the garment and lock the insertion pin into the slider. This mechanism can be prone to jamming and failure and more generally requires the user to free his or her hands. The user must further use one or both hands to move the slider along the ...

Ref.-Nr.: 0705-4770-BC

Sensoren, Geräte und Komponenten

The dynamics of complex flows and turbulences are dominated by vortices of many different scales. In general, the vortex describes the group motion of fluid elements in a circular fashion, whereas the vorticity quantizes this spinning moment of a fluid element confined to a small neighborhood.

For diagnosis of flows, conventional techniques track the movements of small particles added into the flow (e.g., Lagrangian particle tracking, LPT, and particle image velocimetry, PIV). However, ...

Ref.-Nr.: 0305-3252-LI

Medizin : Therapeutika

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...

Ref.-Nr.: 0707-5419-LI

Neue Materialien

Anti-IgG secondary antibodies are major tools for the detection or immobilization of primary antibodies in approaches such as western blotting, ELISA, Co-IP and immunofluorescence. Polyclonal anti-IgG secondary antibodies are produced in animals, such as mouse, rabbit, rat, and goat and are directed against the IgG classes of these animals. Thus, the generation of such secondary antibodies requires the keeping and use of a large number of animals, which is not only costly but also a major ethical ...

Ref.-Nr.: 0104-5066-BC

Sensoren, Geräte und Komponenten

Ultrasound is being used in many fields ranging from medical imaging and therapy to non-destructive testing, contact-free particle handling or spatially selective heating in industrial settings. Often, those applications require shaping (including focusing) of an ultrasonic field. Compared to existing transducers with fixed lenses or phased array transducers (PATs) the present invention allows much more sophisticated sound fields to be generated using much simpler and cheaper technology.

Ref.-Nr.: 0302-1508-LC

IT / Software / Bioinformatik

PC-based software to construct lattice sections and clusters/molecules with extended graphical display and analysis options.

Ref.-Nr.: 0104-5929-BC

Neue Materialien

Since 2000 bioinspired fibrillar dry adhesives have been studied intensively culminating in commercial products already available on the market. Currently known fibrillar adhesives are fully wetted by oils, leading to significantly decreased adhesion and friction performance. Therefore, a high demand exists for reversible dry fibrillar adhesives that can repel oil-like liquids and adhere strongly to surfaces wetted by them.

To meet the aforementioned challenges, an extraordinary fibrillar ...

Ref.-Nr.: 1200-3727 BC

Analytik

BiQ Analyzer is a software tool for easy visualization and quality control of DNA methylation data. With more than a thousand users worldwide, BiQ Analyzer has become a standard tool for processing DNA methylation data from bisulfite sequencing. BiQ Analyzer has been selected by ABI to be part of the Applied Biosystems Software Community Program.

Ref.-Nr. 0402-5003-MG

Grüne Biotechnologie

Carbon fixation is arguably the most important biochemical processes on earth, supporting our biosphere by transforming inorganic carbon into organic matter and literally feeding all life forms. The reductive pentose phosphate cycle (rPP, also known as the Calvin–Benson–Bassham Cycle) is responsible for ≥95% of the carbon fixed in the biosphere. Although under a strong selective pressure for eons, this process displays major inefficiencies, some are due to the low catalytic rate and the ...

Ref.-Nr.: 0707-5236-BC

Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. The availability and the proper choice of the dye is a key factor to success of the entire labelling and imaging procedure. Due to superior brightness and photostability, synthetic dyes often represent an attractive alternative to fluorescent proteins.

Among the multitude of fluorophores reported so far, only rhodamines, carbopyronines, and silicon-rhodamines bearing a carboxyl ...

Ref.-Nr. 1402-3895-BC

IT / Software / Bioinformatik

CellNetAnalyzer is a package for MATLAB and provides a comprehensive and user-friendly environment for structural and functional analysis of biochemical networks. CNA facilitates the analysis of metabolic (stoichiometric) as well as signaling and regulatory networks solely on their network topology, i.e. independent of kinetic mechanisms and parameters. CNA provides a powerful collection of tools and algorithms for structural network analysis which can be started in a menu-controlled ...

Ref.-Nr.: 0402-3923-MG

Prozesse und Methoden (inkl. Screening)

Unicellular eukaryotic green algae from the Chlamydomonas genus are highly attractive for biotechnological production due to their rapid growth and the capability to produce high amounts of biomass at low costs. However, low expression levels of nuclear transgenes in algae have seriously limited the use of algae in production of e.g. “green chemicals”, biofuels or recombinant proteins.

Ref.-Nr.: 1201-5136-BC

Sensoren, Geräte und Komponenten

Evaporation cells for thin film deposition often operate under ultrahigh vacuum or special gas atmosphere, requiring long growth campaigns and short maintenance openings to preserve the best possible vacuum environment. The deposition leads to coating of the inner chamber walls, the removal of which is difficult and very time consuming. Growth control and interruptions during material deposition may require frequent operation of the closure device or shutter. The commonly used shutter (Fig. 1) ...

Ref.-Nr.: 0302-4988-WT

Sensoren, Geräte und Komponenten

Applying high voltages in vacuum applications requires feedthroughs, which electrically insulate the conductor from the vacuum chamber whilst being vacuum-tight. In high- and ultrahigh vacuum environments, the materials used need to be low in outgassing rates. The current technology for feedthroughs withstanding tens to hundreds of kilovolts relies on vacuum-tight ceramic to metal connections, which are heavy, fragile and prone to contamination. Commercially available feedthroughs are stand-alone ...

Ref.-Nr.: 0704-5610-BC

Medizin : Diagnostika
Sensoren, Geräte und Komponenten

Diese neuartige schraubenfreie Kupplung, die auch als Überlastungskupplung eingesetzt werden kann, bietet die Möglichkeit ohne zusätzliches Werkzeug zwei drehbare Elemente auch unter extrem engen Bedingungen, spielfrei und kraftschlüssig mit hoher Präzision miteinander zu verbinden. Bisher auf dem Markt bekannte Kupplungen sind aufgrund ihrer Größe für Anwendungen im Bereich der Elektronik, der Optik, der Messtechnik sowie der Präzisionstechnik ungeeignet. Wohingegen dank der neuen Technologie, ...

Ref.-Nr.: 0042-5177-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

We offer novel phosphenium ligands and corresponding metal complexes (both air stable) that are claimed as substances by granted EP and US patents. The ligands can be prepared in multigram scale by simple direct condensation. The corresponding gold complexes are suitable as homogeneous catalysts in organic synthesis (such as cycloisomerization) that can be easily precipitated and recycled due to their salt properties.

Ref.-Nr.: 1401-4358-WT

IT / Software / Bioinformatik

Das Verfahren der Lock-in-Thermographie (LIT) gestattet es, 2-dimensionale Bilder der Verteilung der in einer Probe dissipierten Leistung zu erzeugen. Allerdings sind diese Lock-in Thermogramme noch durch die unvermeidliche laterale Wärmediffusion in der Probe "verbreitert" (blurred). Das "DECONV"-Programm gestattet es, diese thermische Verbreiterung durch die Anwendung eines örtlichen Entfaltungs-Verfahrens wieder rückgängig zu machen und dadurch die effektive Ortsauflösung der Lock-in-Thermographie ...

Ref.-Nr.: 0204-3316-WT

Sensoren, Geräte und Komponenten

The function of brain tissue is based on the dynamics of numerous nerve cells and their synaptic interaction. Direct electrical interfacing of semiconductors and nerve cells is the physical basis for a systematic development of hybrid neuroelectronic devices, such as neurocomputers and neuroprostheses. Excited nerve cells and field-effect transistors are coupled by a dissipative mechanism: ionic current through the adherent cell membrane flows along the electrical resistance of a narrow layer ...

Ref.-Nr.: 0602-5504-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

A precise and genetically encoded inhibitor for cell-type selective, inducible and reversible inhibition of protein synthesis

Ref.-Nr.: 0202-5001-LI

Analytik
IT / Software / Bioinformatik

Engineering light distributions in a three-dimensional volume to achieve selective illumination profiles is an instrumental task shared by many optical and microscopy techniques. The optimization of the light distribution can lead to significant enhancement of relevant performance figures and ultimately to the extension of the instrument or experimental protocol capabilities1,2,3,4,5. Targeted illumination profiles can be used either to mechanically interact with molecules at nanometer ...

Ref.-Nr.: 0707-5026-BC

Sensoren, Geräte und Komponenten

The estimation of excitation lifetimes based on fluorescence or phosphorescence emission is an essential technique in basic and applied science. It provides information on molecular interactions
as well as on physical properties. Measuring the emission lifetime with spatial resolution provides an imaging modality, which in case of fluorescence is called Fluorescence Lifetime Imaging (FLIM). FLIM is applied extensively in biological imaging in order to determine the conformation, activation, ...

Ref.-Nr.: 1801-4852-WT

Sensoren, Geräte und Komponenten

Resistance induced heating of electrical wiring during operation is one of the limiting factors to design high-power electromagnetic coils. The commonly used approach to eliminate the heating of electrical wires is to introduce a hollow conductive copper wire into electrical wiring and to cool this wire with water. Unfortunately, this approach is not applicable for high power density electromagnetic coil as well as for coils with small dimensions. Another approach to enhance the cooling properties ...

Ref.-Nr.: 1401-4175-WT

IT / Software / Bioinformatik

This software is based on the paper "Quantitative evaluation of electroluminescence images of solar cells" by O. Breitenstein et al.1). It allows to load a number of electroluminescence (EL) images to different biases, which have to be given as ASCii tables.

Ref.-Nr.: 1202-4590-WT

Sensoren, Geräte und Komponenten

An Enhancement Cavity (EC) with at least one toroidal and/or cylindrical mirror is described. This allows for an arbitrary beam ellipticity of the eigenmode. In particular at a stability edge, where the ellipticity diverges with purely spherical optics, a round beam can be obtained.

Ref-Nr.: 0104-4458-BC

Bildgebung und Mikroskopie
Neue Materialien

Semiconductor nanowires are of vital importance for many applications, such as flexible electronics, photonics, sensors, and energy harvesting and storage devices. As standard fabrication procedure, vapor-liquid-solid (VLS) growth employs metal catalyst particles (such as gold) as seeds for growth of nanowires. The seeds are deposited on a solid substrate, melted by heating and then exposed to a gas atmosphere containing source materials of the semiconductor. When the metal droplets are supersaturated, ...

Ref.-Nr.: 0109-4896-LI

Prozesse und Methoden (inkl. Screening)

Fusion Tags Comprising Ubiquitin-like Modifiers and Corresponding Proteases For Protein Purification From Selected Eukaryotic Expression Hosts

Ref.-Nr.: 0707-4198-BC

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Magnetic resonance imaging (MRI) is nowadays a leading mo¬dality for diagnostic imaging with about 100 million examinations per year worldwide. However, when invented by Paul Christian Lauterbur in 1973, MRI was too slow to allow for routine medical applications. A breakthrough was achieved in 1985 by the FLASH (Fast Low Angle Shot) technique developed by Jens Frahm and his team at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Germany. With FLASH the measuring time for a cross-sectional ...

Ref.-Nr.: 0903-4524-LC

Neue Materialien

We offer a new simple and low cost technology to fabricate graphene-encapsulated metal or metal compound nanoparticles. The resulting hybrid nanoparticles are protected by granted substance claims in US, CN, TW and EP (DE, FR, GB, BE). Currently the patent protected graphene coated nano particles are discussed as high performance electrode materials in the lithium ion battery business (for example Samsung's "Graphene Balls").

Ref.-Nr.: 1201-4433-BC

Sensoren, Geräte und Komponenten

In mass spectroscopy, many ion sources that transform the specimen to be tested into gas phase ions operate at ambient or elevated pressure. The generated ions have to be transferred into vacuum for further characterization, for instance in a mass analyzer.
The ion transfer into vacuum represents a major bottleneck. Because the pumping power increases rapidly with the size of an opening, long capillaries or small pinholes have to be used. Their transmission is commonly as low as 1%, in optimal ...

Ref.-Nr.: 0402-5782-MG-ZE

Prozesse und Methoden (inkl. Screening)

The CRISPR-Cas system is a powerful tool for site-specific genome editing. The Cas9endonuclease is capable of introducing DNA double strand breaks at a desired location withhigh precision. The lesion is repaired either in an errorprone process leading to gene inactivation or in a highly accurate way relying on an external template. Modification of the template may serve to introduce selected mutations, modified sequencesorentirely new genes.The accurate pathway comes with low endogenous efficiency. ...

Ref.-Nr.: 0803-5308-MSG

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

An innovative chemical inducer of dimerization for studying protein interactions in cells, that overcomes challenges of available dimerizers.

Ref.-Nr.: 1202-4422-WT

Sensoren, Geräte und Komponenten

A laser device (100), configured for generating laser pulses, has a laser resonator (10) with a gain disk medium (11) and a Kerr medium (12). The laser resonator (10) includes a first mode shaping section (13) which is adapted for shaping a circulating electric field coupled into the gain disk medium (11), and a second mode shaping section (14), which is adapted for shaping the circulating electric field coupled into the Kerr medium (12) independently of the electric field shaping in the first ...

Ref.-Nr.: 1602-5392-LI

Grüne Biotechnologie

Screening the level of specific blumenols in plant leaves allows simple implementation in marker assisted breeding and high-throughput analysis.

Ref.-Nr.: 1401-4359-WT

IT / Software / Bioinformatik

The efficiency of solar cells is strongly affected by local inhomogeneities. Especially inhomogeneities of the dark-current voltage (I-V) characteristic are of interest: The local dark current-voltage characteristic is a measure for the local recombination properties of the solar cell. Lock-in thermography performed in the dark (DLIT) can be used to detect and evaluate locally increased dark current densities.

Ref.-Nr.: 0301-4559-MSG

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

A novel NGS library preparation techniques allowing cheap and reproducible transcriptome analysis of samples with both abundant and rare components, making these techniques very useful in clinical diagnostics as well as biodiversity analysis.

Ref.-Nr.: 1013-4827-MSG

Medizin : Tiermodelle
Forschungs-Reagenzien

A tRNAALA heteroplasmy mouse model to study mitochondrial disorders such as encephalomyophathies, that recapitulates symptoms as observed in human patients with disease-causing mutation in the same mitochondrial gene.

Ref.-Nr.: 0107-4677-BC

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten

Exploiting the benefits offered by magnetic resonance imaging (MRI) at ultra-high fields (≥ 7 Tesla) requires optimized radiofrequency (RF) coils. MRI at UHF operates in a regime where the RF wavelength is comparable to the dimensions of the sample size, resulting in an inhomogeneous distribution of the transmit field (B1+) and in an impaired image quality. An array of independent transmit coils arranged in multiple rows provides the degrees of freedom to influence the ...

Ref.-Nr.: 0214-5247-MG und 0214-5440-MG

IT / Software / Bioinformatik : (andere) Software
Sensoren, Geräte und Komponenten : Sensoren
Sensoren, Geräte und Komponenten : Geräte
Sensoren, Geräte und Komponenten : Komponenten

≠¡]} Julius Kramer

An efficient system to monitor and control animal behavior in wildlife as well as in laboratory settings

Ref.-Nr.: 0042-4938-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

We offer a new family of cationic ligands, namely N-alkyl/aryl pyridiniophosphines. The ligands can be synthesized through a short, scalable, and highly modular route.

Evaluation of their electronic properties evidenced weak σ-donor and quite strong π-acceptor character when used as ancillary ligands.

Ref.-Nr.: 0903-5658-LC; 0903-5696-LC; 0903-5692-LC

Analytik
Bildgebung und Mikroskopie
Neue Materialien

A group of scientists at the MPI for Polymer Research in Mainz developed nano-graphene structures that can be used as a new class of fluorophores for super-resolution microscopy (SMLM and STED).

They perform like hybrids of organic dyes and QDs: they have excellent environment-independent blinking properties, emit high photon numbers, display high photo-stability, possess low toxicity, have a molecular size below 2 nm, and have narrow excitation and emission spectra.

These nanographene ...

Ref.-Nr.: 1012-4430-LI

Prozesse und Methoden (inkl. Screening)

File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)

A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.

Ref.-Nr.: 0803-5480-MSG

Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.

0802-5237-MSG

Medizin : Therapeutika
Medizin : Diagnostika

Newly identified subpopulation of NK cells with the promise to treat obesity and insulin resistance
Left: NKCsf1R_DTR refer to those mice with depleted myeloid NK cells. Right: ITT and GTT refer to insulin and glucose tolerance tests, respectively.

An new approach for treatment of obesity and insulin resistance, that relies on selective ablation of a unique, previously uncharacterized subpopulation of myeloid NK cells.

Ref.-Nr.: 0707-5639-MG

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)

Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression

Ref.-Nr.: 1013-5354-MSG

Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...

Ref.-Nr.: 0401-4561-MG

Medizin : Diagnostika

Synthetic Glycosylphosphatidylinositols (GPIs) with high selectivity and purity for Toxoplasmosis diagnosis and vaccine.

Ref.-Nr.: 0903-4955-LC

Grüne Biotechnologie

The Max Planck Institute for Polymer Research in collaboration with the Institute of Biotechnology and Drug Research (IBWF) developed novel lignin nanocarriers that can be used for smart pesticide delivery in plants for crop protection. The nanocarriers are characterised by a narrow size distribution and an easy manufacturing, furthermore, they can be loaded with hydrophobic pesticides. Injected to plants, the nanocarriers act as a safe store of pesticide, which is released in situ by lignin degrading ...

Ref.-Nr.: 0401-5070-MG

Analytik

Carbohydrates form one of the major classes of biological macromolecules in living organisms, but structural analysis and the quality control of carbohydrate structures represent a major challenge due to the frequent occurrence of isomers that are difficult to distinguish using established techniques.

Changes in protein glycosylation are frequently identified in the context of diseases. For example, alterations in N-glycan profiles from blood plasma have been found to correlate with pathological ...

Ref.-Nr.: 0401-5011-LC-WA

IT / Software / Bioinformatik : Bioinformatik

Researchers of the Max-Planck-Institute for Colloids and Interfaces and the Paul-Ehrlich-Institute (PEI) have developed a novel codon-specific elongation model (COSEM), that is based on the question how codon bias affects protein expression in combination with a deep understanding of protein synthesis.

Ref.-Nr.: 1402-5292-BC

Neue Materialien

For the evaluation of crystallisation processes, process parameters like temperature and concentration can be easily measured. However, to measure the crystal size distribution continuously is a challenging task.
Different methods relaying on back scattering or reflection of monochromatic light can be applied that yield chord-length distributions, which often deviate from the actual crystal or particle size distribution. For analysing the true crystal dimensions and, additionally, the crystal ...

Ref.-Nr.: 0042-4764-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

An easy process for the facile and permanent immobilization of organocatalysts on nylon textiles was developed.
All of the prepared textile-immobilized organocatalysts (a Lewis basic, a Brønsted acidic, and a chiral organocatalyst) display excellent stability, activity and recyclability for various organic transformations. Very good enantioselectivity (>95:5 enantiomeric ratio) can be maintained for more than 250 cycles of asymmetric catalysis. The flexible construction of fabrics allows ...

Ref.-Nr.: 0901-5500-LC

Analytik
Prozesse und Methoden (inkl. Screening) : Chemische

Fig. 1: shows the efficiency of a stainless steel ozone scrubber comprising a thiosulfate coated surface as described herein versus the efficiency of an identical stainless steel ozone scrubber without a thiosulfate coated surface.

Scientists in the group of Atmospheric Chemistry at the Max Planck Institute for Chemistry in Mainz have developed a novel thiosulfate based ozone scrubber to ensure accurate measurements of trace analytes. It is known from the literature that commercial potassium iodide (KI) containing ozone scrubbers can cause errors in the measurement of carbonyl compounds such as aldehydes and ketones due to byproducts formed from the oxidation of KI. Commercial ozone scrubbers based on sodium thiosulfate ...

Ref.-Nr.: 1401-4572-WT

Bildgebung und Mikroskopie
Sensoren, Geräte und Komponenten : Geräte

The state of an electron is completely defined by its momentum and spin. In processes like electron diffraction or photoemission electron ensembles are generated which have a characteristic 3D distribution of momentum and spin. To examine such events the three components of the momentum vector have to be measured. Up to now, the momentum distribution of an ensemble of charged particles was typically measured using energy-dispersive spectrometers based on sequential approaches (sequentially changing ...

Ref.-Nr.: 0104-5603-BC

IT / Software / Bioinformatik

Playful is a scripting language for orchestration of Python modules. Playful allows developers to both organize the logic of activation in reactive behaviour tree and setup sensory-motor couplings, making it especially useful for robotics

Ref.-Nr.: 0707-5297-BC

Bildgebung und Mikroskopie
Neue Materialien

Fluorescent dyes are widely used as indispensable markers in biology, optical microscopy, and analytical chemistry. In particular, the sensitive and stable imaging of cellular components depends on the favourable combination of chemical, biological and physical factors. The availability and proper choice of fluorescent dyes is a key factor to success in the entire labelling and imaging procedure. Due to their superior brightness and photostability, synthetic dyes represent an attractive alternative ...

Ref.-Nr.: 0402-5469-MG

Analytik
IT / Software / Bioinformatik : Bioinformatik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

A computer-implemented method that allows calculating concentration ranges of components within complex networks of biochemical reactions.

Ref.-Nr.: 0041-4518-WT

Neue Materialien

Mesoporous materials present a large surface-to-volume ratio providing sites for catalysis, molecular separation, adsorption or chemical sensing. Some of the classical mesoporous materials employed include silica, alumina, zirconia, zeolites, and other diverse oxides such Ti or Co, and they are synthetized by routes as self-assembly, sol-gel, spray drying and some variations of these methods known in the state of the art. Additionally, some elements of the platinum group such as Pd, Ru, and their ...

Ref.-Nr.: 0105-1318-WT

IT / Software / Bioinformatik

X-ray Detector Software for processing single-crystal monochromatic diffraction data recorded by the rotation method.

Ref.-Nr.: 1629-5142-WT

Sensoren, Geräte und Komponenten : Geräte

Speckle interferometry is an established metrology technique for the characterization of rough objects. Deformations of rough objects under a load can be determined, as well as – with the help of an additional second wavelength – the surface shape of the object under test. As an illustration, Figure 1 (left) shows the so called raw phase as a result of a deformation measurement on a metal plate. The shape and the density of the fringes indicate the response of the metal plate to the load.
Owing ...

Ref.-Nr.: 1801-4849-WT

IT / Software / Bioinformatik

SIMNRA is a Microsoft Windows program for the simulation of energy spectra for ion beam analysis with incident ions from about 100 keV to many MeV. SIMNRA can be used for the simulation of Rutherford backscattering (RBS), elastic backscattering with non-Rutherford cross-sections (EBS), nuclear reaction analysis (NRA), elastic recoil detection analysis (ERDA), and medium energy ion scattering (MEIS). Almost 3000 different non-Rutherford and nuclear reactions cross-sections for incident protons, ...

Ref.-Nr.: 0105-5434-MSG

Analytik

A simple, one-step assay for reliable measurements of NAD(H) and NADP(H) in complex samples, with various applications such as enzymatic assays, clinicals tests, and as point of care tests in the field of ageing.

Ref.-Nr.: 0104-5410-BC

Sensoren, Geräte und Komponenten

Im Zuge der stetigen Weiterentwicklung und Nachfrage auf dem Gebiet der minimal invasiven Chirugie wurde am Max-Planck-Institut für intelligente Systeme in Stuttgart im Team von Herrn Prof Sitti für patientenfreundliche Magen-Darm-Untersuchungen ein kabelloses kapselförmiges Endoskop in Pillengröße, das sogenannte "B-MASCE" entwickelt. Die aus einem Elastomer bestehende Kapsel dient hierbei sowohl als Gehäuse als auch als Federelement für die Nadel. Über in der Kapsel eingebaute Magnete ...

Ref.-Nr.: 0042-5063-LC

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

The ability of hypervalent iodine compounds to act as electrophilic group-transfer reagents has been extensively exploited during the last several years in a variety of synthetically useful transformations
like cyanations and alkynylations. Now it was found, that novel imidazolium sulfuranes, which are isolobal to I(III) species and also depict the key threecenter four-electron bond motive, can be used as an alternative platform for the development of new electrophilic group-transfer reagents.

Imidazolium ...

Ref.-Nr.: 0402-5439-LI

Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.

Ref.-Nr.: 0903-4616-LC

Neue Materialien

Novel gas exchange membranes based on superamphiphobic coatings applied on metal meshes were created and tested in different applications, like gas scrubbing and blood oxygenation.
By using the novel membrans drawbacks of traditional membranes - like insufficient wetting, plugging and depositions chemical incompatibility and temperature instability - can be avoided.

Ref.-Nr.: 0105-4794-MSG

Analytik
Prozesse und Methoden (inkl. Screening) : Physikalische

An apparatus and method allowing high throughput collection of X-ray diffraction data at room temperature.

Ref.-Nr.: 1200-5472-BC

IT / Software / Bioinformatik

The presented technology offers an enhanced streaming rendering pipeline that enables the display of high fidelity, high framerate and high solution for noval views in real time on thin lightweight HMDs suitable especially for VR experiences.

How does it work?

The key idea of this technology is based on a novel algorithm for Potentially Visible Set (PVS) creation: the camera offset space (COS), which for a given point on the image plane provides information under which camera ...

Ref.-Nr.: 0401-5411-LC-WA

Prozesse und Methoden (inkl. Screening) : Chemische
Forschungs-Reagenzien : Andere
Neue Materialien

Figure 1. 1,3-dialkyl-2-thioalkylimidazolium salt as an alkylating agent

The offered thioimidazolium ionic liquids are a class of easily synthesized and harnessed alkylating agents that are completely non-volatile. The active alkylating species is produced in-situ, thus eliminating exposure and the need for specialized equipment. These features can also be used in the solid-state by their attachment to a poly(styrene) support, which allows for easy purification of the product and regeneration of the thioimidazolium alkylator and could be of special interest for flow ...

Ref.-Nr.: 1201-4746-LC

Prozesse und Methoden (inkl. Screening) : Chemische
Neue Materialien

We offer the new composite nanomaterial for sodium ion battery cathodes. These carbon-coated nanosized Na3V2(PO4)3 particles embedded in a highly effective mixed conducting porous carbon matrix can be easily prepared by means of facile soft-chemistry based preparation method with a post heat treatment procedure. The resulting cathodes can be charged and discharged in 6 s with high current density of 22 A/g, deliver the specific capacity of 44 mAh/g and ...

Ref.-No.: 0901-4720-WT

Sensoren, Geräte und Komponenten

In arid and semiarid regions biological soil crusts (BSC) cover about 1/3 of the soil surface. As far as it is known, these BSC (consisting of cyanobacteria, algae, fungi, bryophytes, and other bacteria living in contact with soil particles) are crucial for the global terrestrial carbon and nitrogen cycle. The water status plays a major role, since their water content directly controls the activity of these poikilohydric organisms.